Details of the Drug-Related molecule(s) Interaction Atlas

SN-38G Drug Info

SN-38 Glucuronide; SN-38G; J-004437; RT-015725; SN38 glucuronide; ZINC4099104; 121080-63-5; AC1L9E4E; AKOS025394253; C11376; CHEBI:8990; CHEMBL3526803; CTK8E7286

Cross-matching ID

PubChem CID

443154

ChEBI ID

CHEBI:8990

CAS Number

CAS 121080-63-5

TTD Drug ID

DM2UVNB

INTEDE Drug ID

DR2180

General Information of Drug (ID: DM2UVNB)

Molecule-Related Drug Atlas

Molecule Type:

DME

DOT

Drug Status:

Investigative Drug(s)

Approved Drug(s)

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Drug(s) Metabolized By Beta-glucuronidase (uidA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MUG trihydrate	DM16F75	N. A.	N. A.	Investigative	[3]
MUG trihydrate	DM16F75	N. A.	N. A.	Investigative	[3]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[5]
Conjugated Estrogens	DMLT0E1	Dyspareunia	GA12	Approved	[6]
Indomethacin glucuronide	DMSBENK	N. A.	N. A.	Investigative	[7]
Ketoprofen glucuronide	DMX2FL3	N. A.	N. A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Beta-glucuronidase (uidA)	DE9RA0I	BGLR_ECOLI	Substrate	[1]
Beta-glucuronidase (uidA)	DE2IMU4	A0A127EEJ8_CLOPF	Substrate	[2]
Beta-glucuronidase (uidA)	DERFVMW	A0A0E1EGE5_STRAG	Substrate	[2]
Beta-glucuronidase (uidA)	DE5Z9QK	A0A174H0E7_BACUN	Substrate	[3]
Beta-glucuronidase (uidA)	DELQJ5O	A0A174R8A7_BACUN	Substrate	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
UDP-glucuronosyltransferase 1A1	OTH1C8OJ	UD11_HUMAN	Regulation of Drug Effects	[4]

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References

1	Metabolism of irinotecan and its active metabolite SN-38 by intestinal microflora in rats. Oncol Rep. 2008 Oct;20(4):727-30.
2	Structure and inhibition of microbiome beta-glucuronidases essential to the alleviation of cancer drug toxicity. Chem Biol. 2015 Sep 17;22(9):1238-49.
3	Three structurally and functionally distinct beta-glucuronidases from the human gut microbe Bacteroides uniformis. J Biol Chem. 2018 Nov 30;293(48):18559-18573.
4	Effects of common genetic variants of human uridine diphosphate glucuronosyltransferase subfamilies on irinotecan glucuronidation. Toxicol Mech Methods. 2023 Mar;33(3):197-205. doi: 10.1080/15376516.2022.2109229. Epub 2022 Aug 23.
5	Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats. Cancer Res. 1996 Aug 15;56(16):3752-7.
6	Long-term administration of conjugated estrogen and bazedoxifene decreased murine fecal beta-glucuronidase activity without impacting overall microbiome community. Sci Rep. 2018 May 25;8(1):8166.
7	Bidirectional interactions between indomethacin and the murine intestinal microbiota. Elife. 2015 Dec 23;4:e08973.
8	Bacterial beta-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics. Xenobiotica. 2014 Jan;44(1):28-35.