Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2VC0E)

Drug Name

8-prenylapigenin Drug Info

Synonyms

Licoflavone C; 8-Prenylapigenin; 72357-31-4; UNII-0DQ85982ZY; 4',5,7-Trihydroxy-8-prenylflavone; CHEMBL371562; 0DQ85982ZY; SCHEMBL1231403; MEGxp0_002023; ACon1_001079; ZINC21406; MolPort-001-742-698; 4,5,7-trihydroxy-8-prenylflavone; LMPK12110422; BDBM50240972; 5,7,4'-Trihydroxy-8-prenylflavone; AKOS027326549; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-; NCGC00169697-01; BRD-K74687851-001-01-8

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 10246505
CAS Number: CAS 72357-31-4
TTD Drug ID: DM2VC0E

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Phosphodiesterase 5A (PDE5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tadalafil	DMJZHT1	Benign prostatic hyperplasia	GA90	Approved	[2]
Udenafil	DM1IQRP	Erectile dysfunction	HA01.1	Approved	[3]
Vardenafil	DMTBGW8	Cystic fibrosis	CA25	Approved	[4]
Dipyridamole	DMXY30O	Atrial fibrillation	BC81.3	Approved	[5]
Papaverine	DMCA9QP	Brain ischaemia	8B1Z	Approved	[6]
Avanafil	DM75CXN	Erectile dysfunction	HA01.1	Approved	[7]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[8]
ICARIIN	DMOJQGT	N. A.	N. A.	Phase 3	[1]
EXISULIND	DMBY56U	Colorectal cancer	2B91.Z	Phase 3	[9]
PF-489791	DM3C8GQ	Chronic obstructive pulmonary disease	CA22	Phase 2	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 5A (PDE5A)	TTJ0IQB	PDE5A_HUMAN	Inhibitor	[1]

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References

1	Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J Nat Prod. 2008 Sep;71(9):1513-7.
2	Pulmonary arterial hypertension: the most devastating vascular complication of systemic sclerosis. Rheumatology (Oxford). 2009 Jun;48 Suppl 3:iii25-31.
3	Increased expression of the nitric oxide synthase gene and protein in corpus cavernosum by repeated dosing of udenafil in a rat model of chemical d... Asian J Androl. 2009 Jul;11(4):435-42.
4	The effect of vardenafil, a potent and highly selective phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction, on the cardiovascular response to exercise in patients with coronary artery disease. J Am Coll Cardiol. 2002 Dec 4;40(11):2006-12.
5	Anti-platelet therapy: phosphodiesterase inhibitors.Br J Clin Pharmacol.2011 Oct;72(4):634-46.
6	Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. Asian J Androl. 2003 Mar;5(1):15-8.
7	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
8	cGMP-hydrolytic activity and its inhibition by sildenafil in normal and failing human and mouse myocardium. J Pharmacol Exp Ther. 2009 Sep;330(3):884-91.
9	Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. Cancer Res. 2000 Jul 1;60(13):3338-42.
10	Highlights of the society for medicinesresearch symposium held december 10th 2009 at the national heart and lung institute, London, UK. Drugs of the Future 2010, 35(4): 349-358.