Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3BO8G)

Drug Name

SUVN-G3031 Drug Info

Synonyms

LNXDUSQEXVQFGP-UHFFFAOYSA-N; UNII-65V47O9NOP; 65V47O9NOP; SCHEMBL12484542; N-[4-(1-Cyclobutyl piperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide; 1394808-82-2

Indication

Disease Entry	ICD 11	Status	REF
Cognitive impairment	6D71	Phase 3	[1]

Cross-matching ID

PubChem CID: 60151477
CAS Number: CAS 1394808-82-2
TTD Drug ID: DM3BO8G

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Histamine H3 receptor (H3R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pitolisant	DM8RFNJ	Excessive daytime sleepiness	MG42	Approved	[2]
JNJ-17216498	DM1GRCU	Narcolepsy	7A20	Phase 2	[3]
GSK239512	DMBJMZC	Alzheimer disease	8A20	Phase 2	[4]
JNJ-39220675	DM0WY3H	Alcohol dependence	6C40.2	Phase 2	[5]
AZD-5213	DMOZ04X	Alzheimer disease	8A20	Phase 2	[6]
Bavisant	DM6CVZ5	Attention deficit hyperactivity disorder	6A05.Z	Phase 2	[7]
ABT-288	DM7X54F	Alzheimer disease	8A20	Phase 2	[8]
SAR-110894	DMCLEXM	Alzheimer disease	8A20	Phase 2	[6]
ABT-652	DMLEO2Z	Diabetic neuropathy	8C0Z	Phase 2	[9]
S-38093	DMD8XOY	Alzheimer disease	8A20	Phase 2	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H3 receptor (H3R)	TT9JNIC	HRH3_HUMAN	Antagonist	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
3	Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol. 2004 Nov;143(5):649-61.
4	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
5	JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats. Psychopharmacology (Berl). 2011 Apr;214(4):829-41.
6	SAR110894, a potent histamine H receptor antagonist, displays procognitive effects in rodents. Pharmacol Biochem Behav. 2012 Aug;102(2):203-14.
7	Randomized clinical study of a histamine H3 receptor antagonist for the treatment of adults with attention-deficit hyperactivity disorder. CNS Drugs. 2012 May 1;26(5):421-34.
8	A randomized study of H3 antagonist ABT-288 in mild-to-moderate Alzheimer's dementia.J Alzheimers Dis.2014;42(3):959-71.
9	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032225)
10	Histamine H3 Receptors and Sleep-Wake Regulation. JPET January 2011 vol. 336 no. 1 17-23.