Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3PAS4)

Drug Name

Pyridobenzimidazole Drug Info

Synonyms

ZINC72190057; AKOS026719278; benzo[4,5]imidazo[1,2-a]pyridin-4-ylmethanol

Indication

Disease Entry	ICD 11	Status	REF
Fungal infection	1F29-1F2F	Investigative	[1]

Therapeutic Class

Antifungal Agents

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Fungal Papulacandin B resistance protein 1 (Fung FKS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cilofungin	DMBNWM1	Candidiasis	1F23	Terminated	[2]
L-692289	DMAB1RW	Discovery agent	N.A.	Investigative	[3]
ACULEACIN A	DMR2MUG	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fungal Papulacandin B resistance protein 1 (Fung FKS1)	TTZMS1L	FKS1_YEAST	Inhibitor	[1]

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References

1	Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009). Rev Iberoam Micol. 2009 Mar 31;26(1):15-22.
2	Cryptococcus neoformans resistance to echinocandins: (1,3)beta-glucan synthase activity is sensitive to echinocandins. Antimicrob Agents Chemother. 2005 Jul;49(7):2851-6.
3	Antifungal lipopeptides: Structure-activity relationships of 3-hydroxyglutamine-modified pneumocandin B0 derivatives, Bioorg. Med. Chem. Lett. 5(20):2357-2362 (1995).
4	Synthesis, anti-fungal and 1,3--D-glucan synthase inhibitory activities of caffeic and quinic acid derivatives. Bioorg Med Chem. 2010 Oct 1;18(19):7009-14.