Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3ZHBO)

Drug Name

N'-Pyridoxyl-Lysine-5'-Monophosphate Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 46936882
TTD Drug ID: DM3ZHBO

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Approved Drug(s)

Discontinued Drug(s)

Preclinical Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Pseudomonas Methionine gamma-lyase (Pseudo mdeA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trifluoromethionine	DM4IKBV	Discovery agent	N.A.	Investigative	[2]
------------------------------------------------------------------------------------

Drug(s) Targeting Ornithine decarboxylase (ODC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eflornithine	DMJOQM3	African trypanosomiasis	1F51	Approved	[3]
Putrescine	DMWE6V1	Burn and burn infection	ND90-NE2Z	Discontinued in Phase 2	[1]
G418	DMKTJBU	Discovery agent	N.A.	Investigative	[1]
Pyridoxine-5'-Phosphate	DMFUNL1	Discovery agent	N.A.	Investigative	[1]
APA	DMVG3K1	Discovery agent	N.A.	Investigative	[4]
AMXT-1501	DMPSRZ0	Head and neck cancer	2D42	Investigative	[5]
(2R,5R)-delta-methyl-alpha-acetylenic putrescine	DMSFXEO	Discovery agent	N.A.	Investigative	[3]
ZAPOTIN	DMM4ZKU	Discovery agent	N.A.	Investigative	[6]
LONCHOCARPUSONE	DMWFAPJ	Discovery agent	N.A.	Investigative	[7]
Alpha-monofluoromethyl-3,4-dehydroornithine methyl ester	DMGI9SM	Discovery agent	N.A.	Investigative	[3]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Drug(s) Targeting Bacterial Cystathionine gamma-synthase (Bact metB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GW-3333	DM3PMAZ	Chronic obstructive pulmonary disease	CA22	Preclinical	[8]
------------------------------------------------------------------------------------

Drug(s) Targeting Glycogen phosphorylase muscle form (GP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[9]
JTT-651	DMGP42Q	Type-2 diabetes	5A11	Discontinued in Phase 1	[10]
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[1]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[1]
Indirubin-5-sulfonate	DM08VHZ	Discovery agent	N.A.	Investigative	[1]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[1]
Alpha-D-Glucose-6-Phosphate	DMR0EVN	Discovery agent	N.A.	Investigative	[1]
OLEANOLIC_ACID	DMWDMJ3	Discovery agent	N.A.	Investigative	[11]
Oleanonic acid	DMYPJC3	Discovery agent	N.A.	Investigative	[11]
Nojirimycine Tetrazole	DMYZRTB	Discovery agent	N.A.	Investigative	[12]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Cystathionine gamma-synthase (Bact metB)	TTDU0HP	METB_ECOLI	Inhibitor	[1]
Glycogen phosphorylase muscle form (GP)	TTZHY6R	PYGM_HUMAN	Inhibitor	[1]
Ornithine decarboxylase (ODC1)	TTUMGNO	DCOR_HUMAN	Inhibitor	[1]
Pseudomonas Methionine gamma-lyase (Pseudo mdeA)	TT1UY5C	MEGL_PSEPU	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Kinetic characterization of methionine gamma-lyases from the enteric protozoan parasite Entamoeba histolytica against physiological substrates and trifluoromethionine, a promising lead compound against amoebiasis. FEBS J. 2008 Feb;275(3):548-60.
3	Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony. Exp Parasitol. 1987 Oct;64(2):237-43.
4	2-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity. J Med Chem. 1992 Apr 17;35(8):1339-44.
5	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1276).
6	Synthesis and cancer chemopreventive activity of zapotin, a natural product from Casimiroa edulis. J Med Chem. 2007 Jan 25;50(2):350-5.
7	New bioactive flavonoids and stilbenes in cub resin insecticide. J Nat Prod. 1999 Feb;62(2):205-10.
8	Crystal structures of cystathionine gamma-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor. J Mol Biol. 2001 Aug 24;311(4):789-801.
9	Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase. J Nat Prod. 2009 Aug;72(8):1414-8.
10	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026877)
11	Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystal... J Med Chem. 2008 Jun 26;51(12):3540-54.
12	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.