Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM42XHS)

Drug Name
GT-2016 Drug Info
Synonyms GT 2016; GT-2016; CHEMBL14812; 152241-24-2; SCHEMBL3395544; BDBM86490; MolPort-023-276-421; ZINC1537834; PDSP2_001477; PDSP1_001493; AKOS024457088; API0010299; NCGC00371075-01; LS-193753; L009653
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Terminated [1]
Cross-matching ID
PubChem CID
9839975
TTD Drug ID
DM42XHS

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Histamine H3 receptor (H3R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pitolisant DM8RFNJ Excessive daytime sleepiness MG42 Approved [3]
SUVN-G3031 DM3BO8G Cognitive impairment 6D71 Phase 3 [4]
JNJ-17216498 DM1GRCU Narcolepsy 7A20 Phase 2 [5]
GSK239512 DMBJMZC Alzheimer disease 8A20 Phase 2 [6]
JNJ-39220675 DM0WY3H Alcohol dependence 6C40.2 Phase 2 [7]
AZD-5213 DMOZ04X Alzheimer disease 8A20 Phase 2 [8]
Bavisant DM6CVZ5 Attention deficit hyperactivity disorder 6A05.Z Phase 2 [9]
ABT-288 DM7X54F Alzheimer disease 8A20 Phase 2 [10]
SAR-110894 DMCLEXM Alzheimer disease 8A20 Phase 2 [8]
ABT-652 DMLEO2Z Diabetic neuropathy 8C0Z Phase 2 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H3 receptor (H3R) TT9JNIC HRH3_HUMAN Inhibitor [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001957)
2 New acetylene based histamine H3 receptor antagonists derived from the marine natural product verongamine. Bioorg Med Chem Lett. 1998 May 19;8(10):1133-8.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol. 2004 Nov;143(5):649-61.
6 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
7 JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats. Psychopharmacology (Berl). 2011 Apr;214(4):829-41.
8 SAR110894, a potent histamine H receptor antagonist, displays procognitive effects in rodents. Pharmacol Biochem Behav. 2012 Aug;102(2):203-14.
9 Randomized clinical study of a histamine H3 receptor antagonist for the treatment of adults with attention-deficit hyperactivity disorder. CNS Drugs. 2012 May 1;26(5):421-34.
10 A randomized study of H3 antagonist ABT-288 in mild-to-moderate Alzheimer's dementia.J Alzheimers Dis.2014;42(3):959-71.
11 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032225)