Details of the Drug-Related molecule(s) Interaction Atlas

Dehydrocorticosterone Drug Info

Corticosterone, 11-dehydro-; Corticosterone, dehydro-; Cortisone, 17-deoxy-; 11-Dehydrocorticosterone; Dehydrocortocicosterone; FO4V44A3G3; Kendall's compound A; SCHEMBL141610; 11-DEHYDROCORTICOSTERONE; 11-DHC; 11-Dehydrocorticosteron; 11-Oxo-11-deoxycorticosterone; 17-Deoxycortisone; 21-Hydroxypregn-4-ene-3,11,20-trione; 21-Hydroxypregn-4-ene-3,11-20-trione; 4-Pregnen-21-ol-3,11,20-trione; 4qf7; 72-23-1; AC1NSKHU; CHEBI:78600; EINECS 200-776-2; NSC 9702; NSC-9702; Pregn-4-ene-3,11,20-trione, 21-hydroxy-; UNII-FO4V44A3G3

Cross-matching ID

PubChem CID

5311364

ChEBI ID

CHEBI:78600

CAS Number

CAS 72-23-1

TTD Drug ID

DM48KMB

INTEDE Drug ID

DR2022

General Information of Drug (ID: DM48KMB)

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

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Drug(s) Metabolized By Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cortisone Acetate	DMG8K57	Acne vulgaris	ED80	Approved	[1]
Nabumetone	DMAT2XH	Osteoarthritis	FA00-FA05	Approved	[2]
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Drug(s) Metabolized By Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[3]
Cortisone Acetate	DMG8K57	Acne vulgaris	ED80	Approved	[1]
Beclomethasone	DMZPHIK	Allergic rhinitis	CA08.0	Approved	[3]
Betamethasone Valerate	DMMIAXO	Dermatological disease	DA24.Y	Approved	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2)	DEDH7FP	DHI2_HUMAN	Substrate	[1]
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	DEZDRQO	DHI1_HUMAN	Substrate	[1]

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References

1	Comparative enzymology of 11beta-hydroxysteroid dehydrogenase type 1 from six species. J Mol Endocrinol. 2005 Aug;35(1):89-101.
2	Reductive metabolism of nabumetone by human liver microsomal and cytosolic fractions: exploratory prediction using inhibitors and substrates as marker probes. Eur J Drug Metab Pharmacokinet. 2015 Jun;40(2):127-35.
3	Metabolism of synthetic steroids by the human placenta. Placenta. 2007 Jan;28(1):39-46.