Details of the Drug

General Information of Drug (ID: DMAT2XH)

Drug Name

Nabumetone

Synonyms

NNB-001; NNB-004; NNB-005; Nabumetone (oral); Nabumetone (oral), Nobex; 6-MNA (oral), Nobex

Indication

Disease Entry	ICD 11	Status	REF
Osteoarthritis	FA00-FA05	Approved	[1]
Pain	MG30-MG3Z	Approved	[2]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

228.29

Logarithm of the Partition Coefficient (xlogp)

3.1

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

ADMET Property

BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [3]
Elimination: 0% of drug is excreted from urine in the unchanged form [3]
Half-life: The concentration or amount of drug in body reduced by one-half in 6 - MNA hours [4]
Metabolism: The drug is metabolized via the aldo-keto reductase-1C family by corticosteroid 11-beta-dehydrogenase [5]
MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 125.154 micromolar/kg/day [6]
Vd: The volume of distribution (Vd) of drug is 5-10 L [7]
Water Solubility: The ability of drug to dissolve in water is measured as 0.015 mg/mL [3]

Chemical Identifiers

Formula: C15H16O2
IUPAC Name: 4-(6-methoxynaphthalen-2-yl)butan-2-one
Canonical SMILES: CC(=O)CCC1=CC2=C(C=C1)C=C(C=C2)OC
InChI: InChI=1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3
InChIKey: BLXXJMDCKKHMKV-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 4409
ChEBI ID: CHEBI:7443
CAS Number: 42924-53-8
DrugBank ID: DB00461
TTD ID: D05CKR
INTEDE ID: DR1122
ACDINA ID: D00451

Repurposed Drugs (RPD)

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Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase 2 (COX-2)	TTVKILB	PGH2_HUMAN	Inhibitor	[8]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[9]
Cytochrome P450 1A2 (CYP1A2)_{Main DME}	DEJGDUW	CP1A2_HUMAN	Substrate	[10]
Aldo-keto reductase 1C1 (AKR1C1)	DE7P2FB	AK1C1_HUMAN	Substrate	[11]
Aldo-keto reductase 1C4 (AKR1C4)	DEAJN47	AK1C4_HUMAN	Substrate	[11]
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	DEZDRQO	DHI1_HUMAN	Substrate	[11]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[12]
L-selectin (SELL)	OT6RAJZR	LYAM1_HUMAN	Gene/Protein Processing	[13]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Gene/Protein Processing	[14]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Gene/Protein Processing	[15]
Utrophin	OT7TZ637	UTRN_HUMAN	Gene/Protein Processing	[16]

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Molecular Interaction Atlas (MIA)

MIA Detail

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Molecular Expression Atlas of This Drug

The Studied Disease

Osteoarthritis

ICD Disease Classification

FA00-FA05

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Prostaglandin G/H synthase 2 (COX-2)	DTT	PTGS2	7.93E-04	-0.29	-0.34
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)	DME	HSD11B1	1.64E-01	1.14E-01	1.66E-01
Cytochrome P450 1A2 (CYP1A2)	DME	CYP1A2	7.36E-01	1.62E-02	1.08E-01
Aldo-keto reductase 1C4 (AKR1C4)	DME	AKR1C4	4.05E-01	3.23E-02	2.28E-01
Aldo-keto reductase 1C1 (AKR1C1)	DME	AKR1C1	7.03E-02	6.23E-02	2.87E-01
Cytochrome P450 2C9 (CYP2C9)	DME	CYP2C9	1.90E-01	-9.81E-03	-5.96E-02

Molecular Expression Atlas (MEA)

MEA Detail

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Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Nabumetone

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
Aspirin	DM672AH	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Nabumetone and Aspirin.	Pain [MG30-MG3Z]	[17]
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Coadministration of a Drug Treating the Disease Different from Nabumetone (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Remdesivir	DMBFZ6L	Moderate	Increased risk of hepatotoxicity by the combination of Nabumetone and Remdesivir.	1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019]	[18]
Repaglinide	DM5SXUV	Moderate	Increased risk of hypoglycemia by the combination of Nabumetone and Repaglinide.	Acute diabete complication [5A2Y]	[19]
Glibenclamide	DM8JXPZ	Moderate	Increased risk of hypoglycemia by the combination of Nabumetone and Glibenclamide.	Acute diabete complication [5A2Y]	[19]
Tolazamide	DMIHRNA	Moderate	Increased risk of hypoglycemia by the combination of Nabumetone and Tolazamide.	Acute diabete complication [5A2Y]	[19]
Nateglinide	DMLK2QH	Moderate	Increased risk of hypoglycemia by the combination of Nabumetone and Nateglinide.	Acute diabete complication [5A2Y]	[19]
Glipizide	DMZA5PQ	Moderate	Increased risk of hypoglycemia by the combination of Nabumetone and Glipizide.	Acute diabete complication [5A2Y]	[19]
Inotersen	DMJ93CT	Major	Increased risk of nephrotoxicity by the combination of Nabumetone and Inotersen.	Amyloidosis [5D00]	[20]
Cilostazol	DMZMSCT	Moderate	Increased risk of bleeding by the combination of Nabumetone and Cilostazol.	Arterial occlusive disease [BD40]	[21]
Budesonide	DMJIBAW	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Nabumetone and Budesonide.	Asthma [CA23]	[22]
Ofloxacin	DM0VQN3	Moderate	Additive CNS stimulant effects by the combination of Nabumetone and Ofloxacin.	Bacterial infection [1A00-1C4Z]	[23]
Kanamycin	DM2DMPO	Moderate	Increased risk of nephrotoxicity by the combination of Nabumetone and Kanamycin.	Bacterial infection [1A00-1C4Z]	[24]
Amikacin	DM5PDRB	Moderate	Increased risk of nephrotoxicity by the combination of Nabumetone and Amikacin.	Bacterial infection [1A00-1C4Z]	[24]
Norfloxacin	DMIZ6W2	Moderate	Additive CNS stimulant effects by the combination of Nabumetone and Norfloxacin.	Bacterial infection [1A00-1C4Z]	[23]
ABT-492	DMJFD2I	Moderate	Additive CNS depression effects by the combination of Nabumetone and ABT-492.	Bacterial infection [1A00-1C4Z]	[23]
Gentamicin	DMKINJO	Moderate	Increased risk of nephrotoxicity by the combination of Nabumetone and Gentamicin.	Bacterial infection [1A00-1C4Z]	[24]
Netilmicin	DMRD1QK	Moderate	Increased risk of nephrotoxicity by the combination of Nabumetone and Netilmicin.	Bacterial infection [1A00-1C4Z]	[24]
Levofloxacin	DMS60RB	Moderate	Additive CNS stimulant effects by the combination of Nabumetone and Levofloxacin.	Bacterial infection [1A00-1C4Z]	[23]
Tobramycin	DMUI0CH	Moderate	Increased risk of nephrotoxicity by the combination of Nabumetone and Tobramycin.	Bacterial infection [1A00-1C4Z]	[24]
Lomefloxacin	DMVRH9C	Moderate	Additive CNS stimulant effects by the combination of Nabumetone and Lomefloxacin.	Bacterial infection [1A00-1C4Z]	[23]
Etidronic acid	DM1XHYJ	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Nabumetone and Etidronic acid.	Bone paget disease [FB85]	[25]
Risedronate	DM5FLTY	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Nabumetone and Risedronate.	Bone paget disease [FB85]	[25]
Alendronate	DMY2KX9	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Nabumetone and Alendronate.	Bone paget disease [FB85]	[25]
Trastuzumab Emtansine	DMU1LXS	Moderate	Increased risk of bleeding by the combination of Nabumetone and Trastuzumab Emtansine.	Breast cancer [2C60-2C6Y]	[21]
Iodipamide	DMXIQYS	Major	Increased risk of nephrotoxicity by the combination of Nabumetone and Iodipamide.	Cholelithiasis [DC11]	[26]
Levomilnacipran	DMV26S8	Moderate	Increased risk of bleeding by the combination of Nabumetone and Levomilnacipran.	Chronic pain [MG30]	[27]
Regorafenib	DMHSY1I	Major	Increased risk of bleeding by the combination of Nabumetone and Regorafenib.	Colorectal cancer [2B91]	[20]
Oxaliplatin	DMQNWRD	Moderate	Decreased renal excretion of Nabumetone caused by Oxaliplatin mediated nephrotoxicity.	Colorectal cancer [2B91]	[28]
Drospirenone	DM1A9W3	Moderate	Increased risk of hyperkalemia by the combination of Nabumetone and Drospirenone.	Contraceptive management [QA21]	[29]
Methoxyflurane	DML0RAE	Moderate	Increased risk of nephrotoxicity by the combination of Nabumetone and Methoxyflurane.	Corneal disease [9A76-9A78]	[20]
Ardeparin	DMYRX8B	Major	Increased risk of bleeding by the combination of Nabumetone and Ardeparin.	Coronary thrombosis [BA43]	[30]
Rivaroxaban	DMQMBZ1	Major	Increased risk of bleeding by the combination of Nabumetone and Rivaroxaban.	Deep vein thrombosis [BD71]	[31]
Sertraline	DM0FB1J	Moderate	Increased risk of bleeding by the combination of Nabumetone and Sertraline.	Depression [6A70-6A7Z]	[27]
Fluoxetine	DM3PD2C	Moderate	Increased risk of bleeding by the combination of Nabumetone and Fluoxetine.	Depression [6A70-6A7Z]	[27]
Vilazodone	DM4LECQ	Moderate	Increased risk of bleeding by the combination of Nabumetone and Vilazodone.	Depression [6A70-6A7Z]	[27]
Paroxetine	DM5PVQE	Moderate	Increased risk of bleeding by the combination of Nabumetone and Paroxetine.	Depression [6A70-6A7Z]	[27]
Vortioxetine	DM6F1PU	Moderate	Increased risk of bleeding by the combination of Nabumetone and Vortioxetine.	Depression [6A70-6A7Z]	[27]
Duloxetine	DM9BI7M	Moderate	Increased risk of bleeding by the combination of Nabumetone and Duloxetine.	Depression [6A70-6A7Z]	[27]
Milnacipran	DMBFE74	Moderate	Increased risk of bleeding by the combination of Nabumetone and Milnacipran.	Depression [6A70-6A7Z]	[27]
Escitalopram	DMFK9HG	Moderate	Increased risk of bleeding by the combination of Nabumetone and Escitalopram.	Depression [6A70-6A7Z]	[27]
Clomipramine	DMINRKW	Moderate	Increased risk of bleeding by the combination of Nabumetone and Clomipramine.	Depression [6A70-6A7Z]	[27]
PMID28870136-Compound-49	DMTUC9E	Moderate	Increased risk of bleeding by the combination of Nabumetone and PMID28870136-Compound-49.	Discovery agent [N.A.]	[32]
Fenfluramine	DM0762O	Moderate	Increased risk of bleeding by the combination of Nabumetone and Fenfluramine.	Epilepsy/seizure [8A61-8A6Z]	[27]
Cannabidiol	DM0659E	Moderate	Increased risk of hepatotoxicity by the combination of Nabumetone and Cannabidiol.	Epileptic encephalopathy [8A62]	[20]
Benzthiazide	DMQWZ0H	Moderate	Antagonize the effect of Nabumetone when combined with Benzthiazide.	Essential hypertension [BA00]	[33]
Tazemetostat	DMWP1BH	Moderate	Increased risk of bleeding by the combination of Nabumetone and Tazemetostat.	Follicular lymphoma [2A80]	[21]
Avapritinib	DMK2GZX	Major	Increased risk of bleeding by the combination of Nabumetone and Avapritinib.	Gastrointestinal stromal tumour [2B5B]	[20]
Sulfinpyrazone	DMEV954	Moderate	Increased risk of bleeding by the combination of Nabumetone and Sulfinpyrazone.	Gout [FA25]	[21]
Eplerenone	DMF0NQR	Moderate	Antagonize the effect of Nabumetone when combined with Eplerenone.	Heart failure [BD10-BD1Z]	[34]
Chlorothiazide	DMLHESP	Moderate	Antagonize the effect of Nabumetone when combined with Chlorothiazide.	Heart failure [BD10-BD1Z]	[33]
Furosemide	DMMQ8ZG	Moderate	Antagonize the effect of Nabumetone when combined with Furosemide.	Heart failure [BD10-BD1Z]	[33]
Amiloride	DMRTSGP	Moderate	Antagonize the effect of Nabumetone when combined with Amiloride.	Heart failure [BD10-BD1Z]	[33]
Bumetanide	DMRV7H0	Moderate	Antagonize the effect of Nabumetone when combined with Bumetanide.	Heart failure [BD10-BD1Z]	[33]
Hydroflumethiazide	DMVPUQI	Moderate	Antagonize the effect of Nabumetone when combined with Hydroflumethiazide.	Heart failure [BD10-BD1Z]	[33]
Brentuximab vedotin	DMWLC57	Moderate	Increased risk of hepatotoxicity by the combination of Nabumetone and Brentuximab vedotin.	Hodgkin lymphoma [2B30]	[35]
Efavirenz	DMC0GSJ	Moderate	Increased risk of hepatotoxicity by the combination of Nabumetone and Efavirenz.	Human immunodeficiency virus disease [1C60-1C62]	[36]
Mipomersen	DMGSRN1	Major	Increased risk of hepatotoxicity by the combination of Nabumetone and Mipomersen.	Hyper-lipoproteinaemia [5C80]	[37]
Teriflunomide	DMQ2FKJ	Major	Increased risk of hepatotoxicity by the combination of Nabumetone and Teriflunomide.	Hyper-lipoproteinaemia [5C80]	[38]
BMS-201038	DMQTAGO	Major	Increased risk of hepatotoxicity by the combination of Nabumetone and BMS-201038.	Hyper-lipoproteinaemia [5C80]	[39]
Indapamide	DMGN1PW	Moderate	Antagonize the effect of Nabumetone when combined with Indapamide.	Hypertension [BA00-BA04]	[33]
Trichlormethiazide	DMHAQCO	Moderate	Antagonize the effect of Nabumetone when combined with Trichlormethiazide.	Hypertension [BA00-BA04]	[33]
Hydrochlorothiazide	DMUSZHD	Moderate	Antagonize the effect of Nabumetone when combined with Hydrochlorothiazide.	Hypertension [BA00-BA04]	[40]
Dipyridamole	DMXY30O	Moderate	Increased risk of bleeding by the combination of Nabumetone and Dipyridamole.	Hypertension [BA00-BA04]	[21]
Potassium chloride	DMMTAJC	Moderate	Increased risk of hyperkalemia by the combination of Nabumetone and Potassium chloride.	Hypo-kalaemia [5C77]	[41]
Fludrocortisone	DMUDIR8	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Nabumetone and Fludrocortisone.	Hypo-osmolality/hyponatraemia [5C72]	[22]
Balsalazide	DM7I1T9	Moderate	Increased risk of nephrotoxicity by the combination of Nabumetone and Balsalazide.	Indeterminate colitis [DD72]	[42]
Ibandronate	DM0QZBN	Moderate	Increased risk of nephrotoxicity by the combination of Nabumetone and Ibandronate.	Low bone mass disorder [FB83]	[20]
Porfimer Sodium	DM7ZWNY	Moderate	Increased risk of photosensitivity reactions by the combination of Nabumetone and Porfimer Sodium.	Lung cancer [2C25]	[43]
Calaspargase pegol	DMQZBXI	Moderate	Increased risk of bleeding by the combination of Nabumetone and Calaspargase pegol.	Malignant haematopoietic neoplasm [2B33]	[44]
Idelalisib	DM602WT	Moderate	Increased risk of hepatotoxicity by the combination of Nabumetone and Idelalisib.	Mature B-cell leukaemia [2A82]	[45]
Acalabrutinib	DM7GCVW	Major	Increased risk of bleeding by the combination of Nabumetone and Acalabrutinib.	Mature B-cell lymphoma [2A85]	[46]
Clofarabine	DMCVJ86	Moderate	Increased risk of nephrotoxicity by the combination of Nabumetone and Clofarabine.	Mature B-cell lymphoma [2A85]	[20]
Ibrutinib	DMHZCPO	Major	Increased risk of bleeding by the combination of Nabumetone and Ibrutinib.	Mature B-cell lymphoma [2A85]	[47]
Ponatinib	DMYGJQO	Major	Increased risk of bleeding by the combination of Nabumetone and Ponatinib.	Mature B-cell lymphoma [2A85]	[48]
Exjade	DMHPRWG	Major	Increased risk of nephrotoxicity by the combination of Nabumetone and Exjade.	Mineral absorption/transport disorder [5C64]	[49]
Panobinostat	DM58WKG	Major	Increased risk of bleeding by the combination of Nabumetone and Panobinostat.	Multiple myeloma [2A83]	[18]
Deflazacort	DMV0RNS	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Nabumetone and Deflazacort.	Muscular dystrophy [8C70]	[22]
Ruxolitinib	DM7Q98D	Moderate	Increased risk of bleeding by the combination of Nabumetone and Ruxolitinib.	Myeloproliferative neoplasm [2A20]	[21]
Dasatinib	DMJV2EK	Major	Increased risk of bleeding by the combination of Nabumetone and Dasatinib.	Myeloproliferative neoplasm [2A20]	[50]
Omacetaxine mepesuccinate	DMPU2WX	Major	Increased risk of bleeding by the combination of Nabumetone and Omacetaxine mepesuccinate.	Myeloproliferative neoplasm [2A20]	[51]
Prasugrel	DM7MT6E	Major	Increased risk of bleeding by the combination of Nabumetone and Prasugrel.	Myocardial infarction [BA41-BA43]	[20]
Vorapaxar	DMA16BR	Major	Increased risk of bleeding by the combination of Nabumetone and Vorapaxar.	Myocardial infarction [BA41-BA43]	[52]
Tirofiban	DMQG17S	Moderate	Increased risk of bleeding by the combination of Nabumetone and Tirofiban.	Myocardial infarction [BA41-BA43]	[53]
Sibutramine	DMFJTDI	Moderate	Increased risk of bleeding by the combination of Nabumetone and Sibutramine.	Obesity [5B80-5B81]	[27]
Dexfenfluramine	DMJ7YDS	Moderate	Increased risk of bleeding by the combination of Nabumetone and Dexfenfluramine.	Obesity [5B80-5B81]	[27]
Metolazone	DMB39LO	Moderate	Antagonize the effect of Nabumetone when combined with Metolazone.	Oedema [MG29]	[33]
Polythiazide	DMCH80F	Moderate	Antagonize the effect of Nabumetone when combined with Polythiazide.	Oedema [MG29]	[33]
Rucaparib	DM9PVX8	Moderate	Decreased metabolism of Nabumetone caused by Rucaparib mediated inhibition of CYP450 enzyme.	Ovarian cancer [2C73]	[54]
MK-4827	DMLYGH4	Moderate	Increased risk of bleeding by the combination of Nabumetone and MK-4827.	Ovarian cancer [2C73]	[20]
Abametapir	DM2RX0I	Moderate	Decreased metabolism of Nabumetone caused by Abametapir mediated inhibition of CYP450 enzyme.	Pediculosis [1G00]	[55]
Prednisone	DM2HG4X	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Nabumetone and Prednisone.	Postoperative inflammation [1A00-CA43]	[22]
Hydrocortisone	DMGEMB7	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Nabumetone and Hydrocortisone.	Postoperative inflammation [1A00-CA43]	[22]
Epoprostenol	DMUTYR2	Moderate	Increased risk of bleeding by the combination of Nabumetone and Epoprostenol.	Pulmonary hypertension [BB01]	[56]
Iloprost	DMVPZBE	Moderate	Increased risk of bleeding by the combination of Nabumetone and Iloprost.	Pulmonary hypertension [BB01]	[56]
Everolimus	DM8X2EH	Major	Increased risk of nephrotoxicity by the combination of Nabumetone and Everolimus.	Renal cell carcinoma [2C90]	[57]
Temsirolimus	DMS104F	Major	Increased risk of nephrotoxicity by the combination of Nabumetone and Temsirolimus.	Renal cell carcinoma [2C90]	[57]
Gatifloxacin	DMSL679	Moderate	Additive CNS stimulant effects by the combination of Nabumetone and Gatifloxacin.	Respiratory infection [CA07-CA4Z]	[23]
Sulfasalazine	DMICA9H	Moderate	Increased risk of nephrotoxicity by the combination of Nabumetone and Sulfasalazine.	Rheumatoid arthritis [FA20]	[42]
Dexamethasone	DMMWZET	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Nabumetone and Dexamethasone.	Rheumatoid arthritis [FA20]	[22]
Leflunomide	DMR8ONJ	Major	Increased risk of hepatotoxicity by the combination of Nabumetone and Leflunomide.	Rheumatoid arthritis [FA20]	[38]
Methylprednisolone	DM4BDON	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Nabumetone and Methylprednisolone.	Solid tumour/cancer [2A00-2F9Z]	[22]
Trabectedin	DMG3Y89	Moderate	Increased risk of hepatotoxicity by the combination of Nabumetone and Trabectedin.	Solid tumour/cancer [2A00-2F9Z]	[20]
Prednisolone	DMQ8FR2	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Nabumetone and Prednisolone.	Solid tumour/cancer [2A00-2F9Z]	[22]
Pitolisant	DM8RFNJ	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Nabumetone and Pitolisant.	Somnolence [MG42]	[20]
Naltrexone	DMUL45H	Moderate	Increased risk of hepatotoxicity by the combination of Nabumetone and Naltrexone.	Substance abuse [6C40]	[58]
Caplacizumab	DMPUKA7	Moderate	Increased risk of bleeding by the combination of Nabumetone and Caplacizumab.	Thrombocytopenia [3B64]	[21]
Apixaban	DM89JLN	Major	Increased risk of bleeding by the combination of Nabumetone and Apixaban.	Thrombosis [DB61-GB90]	[20]
Cangrelor	DM8JRH0	Moderate	Increased risk of bleeding by the combination of Nabumetone and Cangrelor.	Thrombosis [DB61-GB90]	[21]
Brilinta	DMBR01X	Moderate	Increased risk of bleeding by the combination of Nabumetone and Brilinta.	Thrombosis [DB61-GB90]	[20]
Cabozantinib	DMIYDT4	Major	Increased risk of bleeding by the combination of Nabumetone and Cabozantinib.	Thyroid cancer [2D10]	[59]
Sirolimus	DMGW1ID	Major	Increased risk of nephrotoxicity by the combination of Nabumetone and Sirolimus.	Transplant rejection [NE84]	[57]
Tacrolimus	DMZ7XNQ	Major	Increased risk of nephrotoxicity by the combination of Nabumetone and Tacrolimus.	Transplant rejection [NE84]	[57]
Chlorpropamide	DMPHZQE	Moderate	Increased risk of hypoglycemia by the combination of Nabumetone and Chlorpropamide.	Type 2 diabetes mellitus [5A11]	[19]
Olsalazine	DMZW9HA	Moderate	Increased risk of nephrotoxicity by the combination of Nabumetone and Olsalazine.	Ulcerative colitis [DD71]	[42]
Cinoxacin	DM4EWNS	Moderate	Additive CNS stimulant effects by the combination of Nabumetone and Cinoxacin.	Urinary tract infection [GC08]	[23]
Plazomicin	DMKMBES	Moderate	Increased risk of nephrotoxicity by the combination of Nabumetone and Plazomicin.	Urinary tract infection [GC08]	[24]
Nalidixic acid	DMRM0JV	Moderate	Additive CNS stimulant effects by the combination of Nabumetone and Nalidixic acid.	Urinary tract infection [GC08]	[23]
Enoxacin	DMYTE6L	Moderate	Additive CNS stimulant effects by the combination of Nabumetone and Enoxacin.	Urinary tract infection [GC08]	[23]
Triamcinolone	DM98IXF	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Nabumetone and Triamcinolone.	Vasomotor/allergic rhinitis [CA08]	[22]
Betrixaban	DM2C4RF	Major	Increased risk of bleeding by the combination of Nabumetone and Betrixaban.	Venous thromboembolism [BD72]	[60]
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⏷ Show the Full List of 119 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
D&C green no. 6	E00337	31416	Colorant
Quinoline yellow WS	E00309	24671	Colorant
Sodium lauryl sulfate	E00464	3423265	Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Sunset yellow FCF	E00255	17730	Colorant
Carmellose sodium	E00625	Not Available	Disintegrant
Eisenoxyd	E00585	56841934	Colorant
Ferric hydroxide oxide yellow	E00539	23320441	Colorant
Ferrosoferric oxide	E00231	14789	Colorant
Hypromellose	E00634	Not Available	Coating agent
Magnesium stearate	E00208	11177	lubricant
Polyethylene glycol 200	E00648	Not Available	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyethylene glycol 400	E00653	Not Available	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyethylene glycol 6000	E00655	Not Available	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polysorbate 80	E00665	Not Available	Dispersing agent; Emollient; Emulsifying agent; Plasticizing agent; Solubilizing agent; Surfactant; Suspending agent
Povidone	E00667	Not Available	Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Silicon dioxide	E00670	Not Available	Anticaking agent; Opacifying agent; Viscosity-controlling agent
Talc	E00520	16211421	Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide	E00322	26042	Coating agent; Colorant; Opacifying agent
Triacetin	E00080	5541	Humectant; Plasticizing agent; Solvent
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⏷ Show the Full List of 19 Pharmaceutical Excipients of This Drug

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Nabumetone 500 mg tablet	500 mg	Oral Tablet	Oral
Nabumetone 750 mg tablet	750 mg	Oral Tablet	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

References

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45	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
46	Product Information. Calquence (acalabrutinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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48	Product Information. Iclusig (ponatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
49	Product Information. Exjade (deferasirox). Novartis Pharmaceuticals, East Hanover, NJ.
50	Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
51	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
52	Product Information. Zontivity (vorapaxar). Merck & Company Inc, Whitehouse Station, NJ.
53	Product Information. Integrilin (eptifibatide). Schering Laboratories, Kenilworth, NJ.
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56	Product Information. Flolan (epoprostenol). Glaxo Wellcome, Research Triangle Park, NC.
57	Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
58	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
59	Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
60	Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals, South San Francisco, CA.