Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5F0QY)

Drug Name

IONIS-416858 Drug Info

Synonyms

IONIS-FXI-LRx

Indication

Disease Entry	ICD 11	Status	REF
Thrombosis	DB61-GB90	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Factor XI messenger RNA (F11 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS-FXI	DMHETPI	Coagulation defect	3B10.0	Phase 2	[2]
BMS-986177	DM4QHZS	Cerebral ischemia	8B11	Phase 2	[3]
alpha-ketothiazole analogue 36	DMN2I3P	Alzheimer disease	8A20	Clinical trial	[4]
FXI-AS1	DMAZ1NW	Thrombosis	DB61-GB90	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Factor XI messenger RNA (F11 mRNA)	TTDM4ZU	FA11_HUMAN	Inhibitor	[1]

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References

1	Clinical pipeline report, company report or official report of Ionis Pharmaceuticals.
2	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).
3	Discovery methods of coagulation-inhibiting drugs. Expert Opin Drug Discov. 2017 Dec;12(12):1195-1205.
4	Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95.
5	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2360).