General Information of Drug (ID: DM6NC8G)

Drug Name
N-(2-(1H-Indol-3-yl)ethyl)biphenyl-4-carboxamide Drug Info
Synonyms
CHEMBL521733; N-(2-(1H-Indol-3-yl)ethyl)biphenyl-4-carboxamide; N-[2-(1H-indol-3-yl)ethyl]biphenyl-4-carboxamide; AC1LG1FS; Oprea1_829316; Oprea1_192683; MolPort-001-987-537; ZINC285233; STK129364; BDBM50272836; AKOS000554028; MCULE-1062167425; NCGC00304458-01; BAS 03049800; ST45172084; AB01300868-01; N-[2-(1H-indol-3-yl)ethyl]-4-phenylbenzamide; N-(2-indol-3-ylethyl)(4-phenylphenyl)carboxamide; Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-amide
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
787236
TTD Drug ID
DM6NC8G

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Apremilast DMTWS9E Psoriasis vulgaris EA90 Approved [2]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [3]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [4]
Ribociclib Succinate DM9CIUW Breast cancer 2C60-2C65 Approved [5]
Trilaciclib DMP5A4T Small-cell lung cancer 2C25.Y Approved [6]
LEE011 DMMX75K Breast cancer 2C60-2C65 Phase 3 [7]
Ro 31-7453 DM83QCL Solid tumour/cancer 2A00-2F9Z Phase 2 [8]
P276-00 DM9DJL2 Mantle cell lymphoma 2A85.5 Phase 2 [9]
P-276 DMMJUHD Breast cancer 2C60-2C65 Phase 2 [10]
G1T38 DMQO2IT Breast cancer 2C60-2C65 Phase 2 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cyclin-dependent kinase 4 (CDK4) TT0PG8F CDK4_HUMAN Inhibitor [1]

References

1 Design, synthesis and biological evaluation of new tryptamine and tetrahydro-beta-carboline-based selective inhibitors of CDK4. Bioorg Med Chem. 2008 Aug 15;16(16):7728-39.
2 Agreement signed with Prostagenics to develop prostate cancer treatment. Innovate Oncology, Inc. 2005.
3 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2017
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021
7 Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clin Cancer Res. 2013 Nov 15;19(22):6173-82.
8 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
9 Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66.
10 Liposarcoma: molecular genetics and therapeutics. Sarcoma. 2011;2011:483154.
11 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)