Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6NM8V)

Drug Name

APLYSAMINE Drug Info

Synonyms

Aplysamine-1; APLYSAMINE; NSC625525; CHEMBL380697; 3-(2,6-Dibromo-4-(2-(dimethylamino)ethyl)phenoxy)-N,N-dimethyl-1-propanamine; AC1L7JVE; AC1Q25RU; BDBM50177729; NSC-625525; 3-[2,6-dibromo-4-(2-dimethylaminoethyl)phenoxy]-N,N-dimethyl-propan-1-amine; 3-(2,6-dibromo-4-(2-(dimethylamino)ethyl)phenoxy)-N,N-dimethylpropan-1-amine; N-(3-(2,6-Dibromo-4-(2-(dimethylamino)ethyl)phenoxy)propyl)-N,N-dimethylamine; 3-[2,6-dibromo-4-(2-dimethylaminoethyl)phenoxy]-N,N-dimethylpropan-1-amine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 362025
TTD Drug ID: DM6NM8V

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Histamine H3 receptor (H3R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pitolisant	DM8RFNJ	Excessive daytime sleepiness	MG42	Approved	[2]
SUVN-G3031	DM3BO8G	Cognitive impairment	6D71	Phase 3	[3]
JNJ-17216498	DM1GRCU	Narcolepsy	7A20	Phase 2	[4]
GSK239512	DMBJMZC	Alzheimer disease	8A20	Phase 2	[5]
JNJ-39220675	DM0WY3H	Alcohol dependence	6C40.2	Phase 2	[6]
AZD-5213	DMOZ04X	Alzheimer disease	8A20	Phase 2	[7]
Bavisant	DM6CVZ5	Attention deficit hyperactivity disorder	6A05.Z	Phase 2	[8]
ABT-288	DM7X54F	Alzheimer disease	8A20	Phase 2	[9]
SAR-110894	DMCLEXM	Alzheimer disease	8A20	Phase 2	[7]
ABT-652	DMLEO2Z	Diabetic neuropathy	8C0Z	Phase 2	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H3 receptor (H3R)	TT9JNIC	HRH3_HUMAN	Inhibitor	[1]

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References

1	The alkaloid conessine and analogues as potent histamine H3 receptor antagonists. J Med Chem. 2008 Sep 11;51(17):5423-30.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol. 2004 Nov;143(5):649-61.
5	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
6	JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats. Psychopharmacology (Berl). 2011 Apr;214(4):829-41.
7	SAR110894, a potent histamine H receptor antagonist, displays procognitive effects in rodents. Pharmacol Biochem Behav. 2012 Aug;102(2):203-14.
8	Randomized clinical study of a histamine H3 receptor antagonist for the treatment of adults with attention-deficit hyperactivity disorder. CNS Drugs. 2012 May 1;26(5):421-34.
9	A randomized study of H3 antagonist ABT-288 in mild-to-moderate Alzheimer's dementia.J Alzheimers Dis.2014;42(3):959-71.
10	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032225)