Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM76GZ0)

Drug Name
Angiotensin-(1-7) Drug Info
Synonyms Ang (1-7); Angiotensin (1-7); Angiotensin-(1-7) (cancer); Angiotensin-(1-7) (cancer), Wake Forest University
Indication
Disease Entry ICD 11 Status REF
Sarcoma 2A60-2C35 Phase 3 [1]
Chemotherapy-induced nausea MD90 Phase 2 [2]
Duchenne dystrophy 8C70 Phase 2 [3]
Lymphoma 2A80-2A86 Phase 2 [2]
Muscular dystrophy 8C70 Phase 1 [3]
Cross-matching ID
PubChem CID
123805
ChEBI ID
CHEBI:55438
CAS Number
CAS 39386-80-6
TTD Drug ID
DM76GZ0
INTEDE Drug ID
DR1903

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Proto-oncogene Mas (MAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
DSC-127 DMM0HAE Diabetic foot ulcer BD54 Phase 3 [4]
AVE 0991 DM9R3WT Discovery agent N.A. Investigative [6]
AR234960 DMTN10D Discovery agent N.A. Investigative [7]
AR244555 DM68QY0 Discovery agent N.A. Investigative [7]
Drug(s) Metabolized By Angiotensin-converting enzyme 2 (ACE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BRADYKININ DM4R6UV N. A. N. A. Phase 1 [8]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Proto-oncogene Mas (MAS) TTOISYB MAS_HUMAN Agonist [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Angiotensin-converting enzyme 2 (ACE2) Main DME DEGPI81 ACE2_HUMAN Substrate [5]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 582).
2 ClinicalTrials.gov (NCT01121120) Acceleration of Platelet Recovery Following Autologous Peripheral Blood Stem Cell Transplant (PBSC) in Hodgkin, Non-Hodgkin Lymphoma or Multiple Myeloma Patients. U.S. National Institutes of Health.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 New therapeutic pathways in the RAS. J Renin Angiotensin Aldosterone Syst. 2012 Dec;13(4):505-8.
5 Metabolism of angiotensin-(1-7) by angiotensin-converting enzyme. Hypertension. 1998 Jan;31(1 Pt 2):362-7.
6 Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney. Hypertension. 2004 Oct;44(4):490-6.
7 Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection. Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H299-311.
8 Nunn's Applied Respiratory Physiology (Eighth Edition). Chapter 11 - Nonrespiratory Functions of the Lung.2017, Pages 203-214.e2