Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7GH5Z)

• Drug Name: BB-1101 Drug Info
• Synonyms: BB-1101; CHEMBL432079; SCHEMBL1844243; BDBM50070453

Indication

Disease Entry	ICD 11	Status	REF
Multiple sclerosis	8A40	Terminated	[1]

• Cross-matching ID:
  PubChem CID: 9908389
  TTD Drug ID: DM7GH5Z

Molecule-Related Drug Atlas

Drug(s) Targeting Matrix metalloproteinase-8 (MMP-8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CIPEMASTAT	DM803GL	Rheumatoid arthritis	FA20	Phase 3	[4]
GM6001	DM7V9CT	Corneal ulcer	9A76	Discontinued in Phase 2	[5]
SC-44463	DMBPNKT	N. A.	N. A.	Terminated	[6]
MMI270	DM38N2K	Discovery agent	N.A.	Investigative	[7]
IK-862	DMJA4UE	Discovery agent	N.A.	Investigative	[8]
2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide	DMCNV5J	Discovery agent	N.A.	Investigative	[9]
SL422	DM3I2US	Discovery agent	N.A.	Investigative	[10]
[2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid	DM37C25	Discovery agent	N.A.	Investigative	[9]
N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide	DM4VADN	Discovery agent	N.A.	Investigative	[9]
Ro-37-9790	DM83QMZ	Discovery agent	N.A.	Investigative	[11]

Drug(s) Targeting Matrix metalloproteinase-1 (MMP-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prinomastat	DM9HOKG	Lung cancer	2C25.0	Approved	[12]
Marimastat	DM6V34C	Pancreatic cancer	2C10	Phase 3	[13]
CIPEMASTAT	DM803GL	Rheumatoid arthritis	FA20	Phase 3	[4]
Apratastat	DM8W4N9	Rheumatoid arthritis	FA20	Phase 2	[14]
PMID29130358-Compound-Figure18(14a)	DMHIBTZ	N. A.	N. A.	Patented	[15]
PMID29130358-Compound-Figure10(2a)	DMFWXPS	N. A.	N. A.	Patented	[15]
BMS 275291	DMKSFPE	Kaposi sarcoma	2B57	Discontinued in Phase 3	[16]
GM6001	DM7V9CT	Corneal ulcer	9A76	Discontinued in Phase 2	[17]
RS-130830	DMOTANY	Hepatitis C virus infection	1E51.1	Discontinued in Phase 2	[18]
XL784	DMICR39	Diabetic nephropathy	GB61.Z	Discontinued in Phase 2	[19]

Drug(s) Targeting Matrix metalloproteinase-2 (MMP-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prinomastat	DM9HOKG	Lung cancer	2C25.0	Approved	[12]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[20]
Marimastat	DM6V34C	Pancreatic cancer	2C10	Phase 3	[13]
Neovastat	DMXTYWJ	Non-small-cell lung cancer	2C25.Y	Phase 1	[21]
Metastat	DMTQ4PN	Acne vulgaris	ED80	Phase 1	[22]
PMID29130358-Compound-Figure18(14a)	DMHIBTZ	N. A.	N. A.	Patented	[15]
PMID29130358-Compound-Figure10(2a)	DMFWXPS	N. A.	N. A.	Patented	[15]
PMID29130358-Compound-Figure16(9b)	DMPAQLZ	N. A.	N. A.	Patented	[15]
PMID29130358-Compound-SB-3CT	DMC64XQ	N. A.	N. A.	Patented	[15]
PMID29130358-Compound-Figure16(9a)	DMKX5R8	N. A.	N. A.	Patented	[15]

Drug(s) Targeting Matrix metalloproteinase-3 (MMP-3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID29130358-Compound-Figure10(2a)	DMFWXPS	N. A.	N. A.	Patented	[15]
GM6001	DM7V9CT	Corneal ulcer	9A76	Discontinued in Phase 2	[17]
RS-130830	DMOTANY	Hepatitis C virus infection	1E51.1	Discontinued in Phase 2	[18]
PG-530742	DMELXBQ	Myocardial infarction	BA41-BA43	Discontinued in Phase 2	[23]
Batimastat	DM92VRP	Idiopathic pulmonary fibrosis	CB03.4	Preclinical	[24]
SC-44463	DMBPNKT	N. A.	N. A.	Terminated	[25]
L-696418	DMV785R	N. A.	N. A.	Terminated	[26]
RO-319790	DML3NEU	Rheumatoid arthritis	FA20	Terminated	[27]
MMI270	DM38N2K	Discovery agent	N.A.	Investigative	[22]
IK-862	DMJA4UE	Discovery agent	N.A.	Investigative	[8]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Matrix metalloproteinase-1 (MMP-1)	TTMX39J	MMP1_HUMAN	Inhibitor	[2]
Matrix metalloproteinase-2 (MMP-2)	TTLM12X	MMP2_HUMAN	Inhibitor	[2]
Matrix metalloproteinase-3 (MMP-3)	TTUZ2L5	MMP3_HUMAN	Inhibitor	[2]
Matrix metalloproteinase-8 (MMP-8)	TTGA1IV	MMP8_HUMAN	Inhibitor	[3]

References

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• [19] Agents in development for the treatment of diabetic nephropathy. Expert Opin Emerg Drugs. 2008 Sep;13(3):447-63.
• [20] Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzenesulfonyl (Ns) protecting group. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4171-4.
• [21] Neovastat, a naturally occurring multifunctional antiangiogenic drug, in phase III clinical trials. Semin Oncol. 2001 Dec;28(6):620-5.
• [22] Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer. 2002 Sep;2(9):657-72.
• [23] Selective matrix metalloproteinase inhibition attenuates progression of left ventricular dysfunction and remodeling in dogs with chronic heart fail... Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2522-7.
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