Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7TX3D)

Drug Name

CM-156 Drug Info

Synonyms

Sigma opioid antagonists (addiction); Sigma opioid antagonists (addiction), University of Mississippi; 2(3H)-benzoxalones and 2(3H)-benzothiazolones (addiction), University of Mississippi

Indication

Disease Entry	ICD 11	Status	REF
Drug abuse	6C4G.1Z	Investigative	[1]

Cross-matching ID

TTD Drug ID: DM7TX3D

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Opioid receptor sigma 1 (OPRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dextromethorphan	DMUDJZM	Allergic rhinitis	CA08.0	Approved	[2]
Dextromethorphan Polistirex	DMEHCY5	Dry cough	MD12	Approved	[3]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[4]
AVP-786	DMV1SOR	Alzheimer disease	8A20	Phase 3	[1]
ADX N05	DMLBYRA	Mood disorder	6A60-6E23	Phase 3	[5]
Igmesine	DMH97XA	Major depressive disorder	6A70.3	Phase 2	[6]
OPC-14523	DMB1WF3	Bulimia nervosa	6B81	Phase 2	[7]
ANAVEX 2-73	DM67OU4	Alzheimer disease	8A20	Phase 1	[8]
SSR-125047	DMSUFW6	Schizophrenia	6A20	Phase 1	[9]
SA-5845	DM6XZRL	Central nervous system disease	8A04-8D87	Phase 1	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Opioid receptor sigma 1 (OPRS1)	TT5TPI6	SGMR1_HUMAN	Antagonist	[1]

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References

1	Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.
2	Dextromethorphan/quinidine: AVP 923, dextromethorphan/cytochrome P450-2D6 inhibitor, quinidine/dextromethorphan. Drugs R D. 2005;6(3):174-7.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031127)
5	Clinical pipeline report, company report or official report of SK BioPhamaceuticals.
6	Antiamnesic and neuroprotective effects of donepezil against learning impairments induced in mice by exposure to carbon monoxide gas. J Pharmacol Exp Ther. 2006 Jun;317(3):1307-19.
7	Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523. Neuropharmacology. 2001 Dec;41(8):976-88.
8	2011 Pipeline of Anavex.
9	The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22.
10	Tumor imaging with 2 sigma-receptor ligands, 18F-FE-SA5845 and 11C-SA4503: a feasibility study. J Nucl Med. 2004 Nov;45(11):1939-45.