Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7ZSVD)

Drug Name

ISODISPAR B Drug Info

Synonyms

ISODISPAR B; CHEMBL198873; AC1O5FK1; BDBM50172747; 5,7-dihydroxy-8-(3-methylbutanoyl)-4-phenylchromen-2-one; 5,7-Dihydroxy-8-(3-methyl-butyryl)-4-phenyl-chromen-2-one; 5,7-dihydroxy-8-(3-methylbutanoyl)-4-phenyl-chromen-2-one; 4-Phenyl-5,7-dihydroxy-8-(3-methylbutyryl)-2H-1-benzopyran-2-one; 2H-1-Benzopyran-2-one, 5,7-dihydroxy-8-(3-methyl-1-oxobutyl)-4-phenyl-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 6483316
TTD Drug ID: DM7ZSVD

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Human immunodeficiency virus Reverse transcriptase (HIV RT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[2]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[3]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[4]
Tenofovir	DM1IS6U	Chronic hepatitis B virus infection		Approved	[2]
Lamivudine	DMI347A	Chronic HBV infection	1E51.0Z	Approved	[5]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[6]
Delavirdine	DM3NF5G	Human immunodeficiency virus infection	1C62	Approved	[5]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[5]
Rilpivirine	DMJ0QOW	Human immunodeficiency virus infection	1C62	Approved	[7]
Etravirine	DMGV8QU	Human immunodeficiency virus-1 infection	1C62	Approved	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human immunodeficiency virus Reverse transcriptase (HIV RT)	TT84ETX	POL_HV1B1	Inhibitor	[1]

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References

1	4-Phenylcoumarins as HIV transcription inhibitors. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4447-50.
2	Antiviral drugs in current clinical use. J Clin Virol. 2004 Jun;30(2):115-33.
3	HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism.Nat Struct Mol Biol.2012 Jan 22;19(2):253-9.
4	A peptide inhibitor of HIV-1 reverse transcriptase using alpha,beta-dehydro residues: a structure-based computer model. J Biomol Struct Dyn. 1998 Oct;16(2):347-54.
5	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6	Quadruple nucleos(t)ide reverse transcriptase inhibitors-only regimen of tenofovir plus zidovudine/lamivudine/abacavir in heavily pre-treated HIV-1 infected patients: salvage therapy or backbone only Curr HIV Res. 2009 May;7(3):320-6.
7	Emerging antiviral drugs. Expert Opin Emerg Drugs. 2008 Sep;13(3):393-416.
8	2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.