Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM84AD1)

Drug Name

Arofylline Drug Info

Synonyms

Arofyllin; KM09088; Arofylline (USAN/INN); 3-(4-chlorophenyl)-1-propyl-3,7-dihydro-1H-purine-2,6-dione; 3-(4-chlorophenyl)-1-propyl-7H-purine-2,6-dione

Indication

Disease Entry	ICD 11	Status	REF
Chronic obstructive pulmonary disease	CA22	Phase 3	[1]

Cross-matching ID

PubChem CID: 166553
CAS Number: CAS 136145-07-8
TTD Drug ID: DM84AD1

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Phosphodiesterase 4 (PDE4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Apremilast	DMTWS9E	Psoriasis vulgaris	EA90	Approved	[2]
Oxtriphylline	DMLHSE3	Cough	MD12	Approved	[3]
Roflumilast	DMPGHY8	Asthma	CA23	Approved	[4]
Ibudilast	DM4LSPN	Castleman's disease	4B2Y	Approved	[5]
crisaborole	DMNVKU6	Atopic dermatitis	EA80	Approved	[6]
ARQ-151	DML61S4	Atopic dermatitis	EA80	Phase 3	[7]
SUN13834	DMPK34E	Gram-positive bacterial infection	1B74-1G40	Phase 2	[8]
ONO-6126	DMRT28X	Chronic obstructive pulmonary disease	CA22	Phase 2	[1]
E6005	DM1S489	Atopic dermatitis	EA80	Phase 2	[9]
IC-485	DMB1UYV	Chronic obstructive pulmonary disease	CA22	Phase 2	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 4 (PDE4)	TTV5CGO	NOUNIPROTAC	Inhibitor	[1]

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References

1	Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
2	Highly selective phosphodiesterase 4 inhibitors for the treatment of allergic skin diseases and psoriasis. Inflamm Allergy Drug Targets. 2007 Mar;6(1):17-26.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
5	Therapeutic targeting of 3',5'-cyclic nucleotide phosphodiesterases: inhibition and beyond. Nat Rev Drug Discov. 2019 Oct;18(10):770-796.
6	2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.
7	Trial of Roflumilast Cream for Chronic Plaque Psoriasis. N Engl J Med. 2020 Jul 16;383(3):229-239.
8	Ocular hypotension induced by topical dopaminergic drugs and phosphodiesterase inhibitors. Eur J Pharmacol. 1994 Jun 2;258(1-2):85-94.
9	Antipruritic effect of the topical phosphodiesterase 4 inhibitor E6005 ameliorates skin lesions in a mouse atopic dermatitis model. J Pharmacol Exp Ther. 2013 Jul;346(1):105-12.