Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8P3N5)

• Drug Name: ISIS-AR Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Prostate cancer	2C82.0	Phase 1	[1]

• Cross-matching ID: TTD Drug ID: DM8P3N5

Molecule-Related Drug Atlas

Drug(s) Targeting Androgen receptor messenger RNA (AR mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[3]
BAY 86-5044	DMRZLU4	Breast cancer	2C60-2C65	Phase 2	[4]
TRC-253	DMXI8CD	Prostate cancer	2C82.0	Phase 1/2	[5]
IONIS-AR-2.5Rx	DMF2DMS	Prostate cancer	2C82.0	Phase 1/2	[6]
EZN-4176	DMNPS59	Prostate cancer	2C82.0	Phase 1	[7]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[8]
RU-58841	DMMEAZ2	Acne vulgaris	ED80	Discontinued in Phase 1	[9]
flavone	DMEQH6J	Discovery agent	N.A.	Investigative	[10]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[10]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Androgen receptor messenger RNA (AR mRNA)	TTKPW01	ANDR_HUMAN	Not Available	[2]

References

• [1] Clinical pipeline report, company report or official report of ISIS Pharmaceuticals.
• [2] Clinical pipeline report, company report or official report of ISIS Pharmaceuticals.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 628).
• [4] Synthesis and biological activity of a novel, highly potent progesterone receptor antagonist. J Med Chem. 2000 Dec 28;43(26):5010-6.
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [6] Perspectives on the current and emerging chemical androgen receptor antagonists for the treatment of prostate cancer. Expert Opin Pharmacother. 2019 Feb;20(2):163-172.
• [7] 2011 Pipeline of Santaris Pharma.
• [8] Effect of essential oils, such as raspberry ketone and its derivatives, on antiandrogenic activity based on in vitro reporter gene assay. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2111-4.
• [9] Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen recepto... J Med Chem. 2008 Nov 13;51(21):7010-4.
• [10] Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4706-10.