Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8RFNJ)

Drug Name
Pitolisant Drug Info
Synonyms
Pitolisant; 362665-56-3; TIPROLISANT; BF2.649; UNII-4BC83L4PIY; 1-[3-[3-(4-chlorophenyl)propoxy]propyl]piperidine; Pitolisant (BF2.649); 1-(3-(3-(4-Chlorophenyl)propoxy)propyl)piperidine; 4BC83L4PIY; Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-; CHEMBL462605; wakix; 1-[3-[3-(4-Chlorophenyl)propoxy]propyl]-piperidinehydrochloride; 1-{3-[3-(4-chlorophenyl)propoxy]propyl}piperidine; Tirolisant; Pitolisant (INN); tiprolisant [USAN]; Wakix (TN); Pitolisant [USAN:INN]; SCHEMBL117648; GTPL8924; CTK1B6404; HBS-101
Indication
Disease Entry ICD 11 Status REF
Excessive daytime sleepiness MG42 Approved [1]
Schizophrenia 6A20 Phase 3 [2]
Cross-matching ID
PubChem CID
9948102
ChEBI ID
CHEBI:134709
CAS Number
CAS 362665-56-3
TTD Drug ID
DM8RFNJ
ACDINA Drug ID
D01345

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Histamine H3 receptor (H3R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
SUVN-G3031 DM3BO8G Cognitive impairment 6D71 Phase 3 [3]
JNJ-17216498 DM1GRCU Narcolepsy 7A20 Phase 2 [4]
GSK239512 DMBJMZC Alzheimer disease 8A20 Phase 2 [5]
JNJ-39220675 DM0WY3H Alcohol dependence 6C40.2 Phase 2 [6]
AZD-5213 DMOZ04X Alzheimer disease 8A20 Phase 2 [7]
Bavisant DM6CVZ5 Attention deficit hyperactivity disorder 6A05.Z Phase 2 [8]
ABT-288 DM7X54F Alzheimer disease 8A20 Phase 2 [9]
SAR-110894 DMCLEXM Alzheimer disease 8A20 Phase 2 [7]
ABT-652 DMLEO2Z Diabetic neuropathy 8C0Z Phase 2 [10]
S-38093 DMD8XOY Alzheimer disease 8A20 Phase 2 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H3 receptor (H3R) TT9JNIC HRH3_HUMAN Agonist [1]

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
2 ClinicalTrials.gov (NCT01800045) Pitolisant to Assess Weekly Frequency of Cataplexy Attacks and EDS in Narcoleptic Patients (HARMONY CTP). U.S. National Institutes of Health.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Acute wake-promoting actions of JNJ-5207852, a novel, diamine-based H3 antagonist. Br J Pharmacol. 2004 Nov;143(5):649-61.
5 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
6 JNJ-39220675, a novel selective histamine H3 receptor antagonist, reduces the abuse-related effects of alcohol in rats. Psychopharmacology (Berl). 2011 Apr;214(4):829-41.
7 SAR110894, a potent histamine H receptor antagonist, displays procognitive effects in rodents. Pharmacol Biochem Behav. 2012 Aug;102(2):203-14.
8 Randomized clinical study of a histamine H3 receptor antagonist for the treatment of adults with attention-deficit hyperactivity disorder. CNS Drugs. 2012 May 1;26(5):421-34.
9 A randomized study of H3 antagonist ABT-288 in mild-to-moderate Alzheimer's dementia.J Alzheimers Dis.2014;42(3):959-71.
10 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032225)
11 Histamine H3 Receptors and Sleep-Wake Regulation. JPET January 2011 vol. 336 no. 1 17-23.