General Information of Drug (ID: DM98VMZ)

Drug Name
NS-11757 Drug Info
Synonyms NS-309; NS-4591; NS-6277; NS-8593; Calcium-activated potassium channel modulators, Neurosearch
Indication
Disease Entry ICD 11 Status REF
Atrial fibrillation BC81.3 Investigative [1]
Cross-matching ID
PubChem CID
25102784
TTD Drug ID
DM98VMZ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [3]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [4]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [5]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [6]
Acetohexamide DMR6N7H Diabetic complication 5A2Y Approved [7]
Gliclazide DMN6QO5 Diabetic complication 5A2Y Approved [8]
NN-414 DMRJEXM Type-1 diabetes 5A10 Phase 1 [9]
HBR-985 DMKDBFL Discovery agent N.A. Investigative [10]
⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
ATP-binding cassette transporter C8 (ABCC8) TTP835K ABCC8_HUMAN Modulator [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2944).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2944).
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4 Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. J Clin Invest. 2009 Jan;119(1):80-90.
5 Metformin/Repaglinide (PrandiMet) for type 2 diabetes. Med Lett Drugs Ther. 2009 Jun 1;51(1313):41-3.
6 Mechanism of disopyramide-induced hypoglycaemia in a patient with Type 2 diabetes. Diabet Med. 2009 Jan;26(1):76-8.
7 Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection.Diabetes.2005 Nov;54(11):3065-72.
8 Structural basis for the interference between nicorandil and sulfonylurea action. Diabetes. 2001 Oct;50(10):2253-9.
9 Attenuation of hyperinsulinemia by NN414, a SUR1/Kir6.2 selective K-adenosine triphosphate channel opener, improves glucose tolerance and lipid profile in obese Zucker rats.Metabolism.2004 Apr;53(4):441-7.
10 Cardioselective K(ATP) channel blockers derived from a new series of m-anisamidoethylbenzenesulfonylthioureas. J Med Chem. 2001 Mar 29;44(7):1085-98.