Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9KTH6)

Drug Name

1-(3-cyano-2-hydroxyphenyl)-3-phenylurea Drug Info

Synonyms

CHEMBL239558; 1-(3-cyano-2-hydroxyphenyl)-3-phenylurea; SCHEMBL7488503

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting C-X-C chemokine receptor type 2 (CXCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[2]
Clotrimazole	DMMFCIH	Cutaneous candidiasis	1F23.14	Approved	[3]
Reparixin	DMVBA7I	Pancreatic islet transplantation failure	NE84	Phase 3	[2]
SCH-527123	DMPUAOE	Chronic obstructive pulmonary disease	CA22	Phase 2	[4]
SB-265610	DM8TKG5	Asthma	CA23	Phase 2	[5]
AZD-5069	DM3JSFK	Asthma	CA23	Phase 2	[6]
PS-938285	DMHZIFJ	Chronic obstructive pulmonary disease	CA22	Phase 2	[7]
GSK1325756	DMA6RBF	Chronic obstructive pulmonary disease	CA22	Phase 2	[8]
SB-656933	DMCY785	Chronic obstructive pulmonary disease	CA22	Phase 2	[9]
RIST4721	DMA3DKO	Hidradenitis suppurativa	ED92.0	Phase 2	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C-X-C chemokine receptor type 2 (CXCR2)	TT30C9G	CXCR2_HUMAN	Inhibitor	[1]

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References

1	Comparison of N,N'-diarylsquaramides and N,N'-diarylureas as antagonists of the CXCR2 chemokine receptor. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1713-7.
2	2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31.
3	Mode of action of clotrimazole: implications for therapy. Am J Obstet Gynecol. 1985 Aug 1;152(7 Pt 2):939-44.
4	CXCR2 Antagonist MK-7123.A Phase 2 Proof-of-Concept Trial for Chronic Obstructive Pulmonary Disease.Am J Respir Crit Care Med.2015 May 1;191(9):1001-11.
5	Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91.
6	Pharmacological characterization of AZD5069, a slowly reversible CXC chemokine receptor 2 antagonist. J Pharmacol Exp Ther. 2015 May;353(2):340-50.
7	CenterWatch. Drugs in Clinical Trials Database. CenterWatch. 2008.
8	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
9	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
10	A Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study to Evaluate the Efficacy and Safety of RIST4721 in Subjects with Palmoplantar Pustulosis. Dermatol Ther (Heidelb). 2021 Dec;11(6):2179-2193.