Details of the Drug

General Information of Drug (ID: DMMFCIH)

Drug Name
Clotrimazole
Synonyms
Canesten; Canestene; Canestine; Canifug; Chlotrimazole; Cimitidine; Clomatin; Clotrimaderm; Clotrimazol; Clotrimazolum; Clotrimeizol; Cutistad; Empecid; Esparol; FemCare; Gynix; Kanesten; Klotrimazole; Lotrimax; Lotrimin; Monobaycuten; Mycelax; Mycelex; Mycofug; Mycosporin; Mykosporin; Nalbix; Pedisafe; Rimazole; Stiemazol; Tibatin; Trimysten; Canesten Cream; Canesten Solution; Clotrimazole Schering Brand; Desamix F; Fem Care; Gyne lotrimin; Lotrimin AF Cream; Lotrimin AF Lotion; Lotrimin AF Solution; Lotrimin Af; Lotrimin Cream; Lotrimin Lotion; Lotrimin Solution; Mycelex Cream; Mycelex G; Mycelex OTC; Mycelex Solution; Mycelex Troches; Mycelex Twin Pack; Myclo Cream; Myclo Solution; Myclo Spray Solution; Schering Brand of Clotrimazole; B 5097; Bay b 9057; Bayer Brand 1 of Clotrimazole; Bayer Brand 2 of Clotrimazole; C 6019; FB 5097; FB b 5097; Mycelex 7; Trivagizole 3; Bay-B 5097; Candid Vaginal (TN); Candinil (TN); Canesten (TN); Canesten 1-Day Therapy; Canesten 3-Day Therapy; Canesten 6-Day Therapy; Clobrate VT (TN); Clotrimazol [INN-Spanish]; Clotrimazolum [INN-Latin]; DRG-0072; Gino-Lotremine; Gyne-Lotrimin; Gyne-Lotrimin 3; Gyne-Lotrimin 3 Combination Pack; Gyne-Lotrimin Combination Pack; Lotrimin (TN); Lotrimin AF Jock-Itch Cream; Mono-baycuten; Mycelex (TN); Mycelex-7; Mycelex-7 Combination Pack; Mycelex-G; Mycelex: MycosporinRimazole; Myclo-Gyne; Neo-Zol Cream; Pan-Fungex; Cancap-VT (TN); Candid - V Gel (TN); Canesten 1-Day Cream Combi-Pak; Canesten Combi-Pak 1-Day Therapy; Canesten Combi-Pak 3-Day Therapy; Clotrimazole (JP15/USP/INN); Clotrimazole [USAN:INN:BAN:JAN]; (Chlorotrityl)imidazole; 1-(o-Chlorotrityl)imidazole
Indication
Disease Entry ICD 11 Status REF
Cutaneous candidiasis 1F23.14 Approved [1]
Fungal infection 1F29-1F2F Approved [2]
Mycoses 1F2Z Approved [1]
Oral candidiasis 1F23.0 Approved [1]
Tinea corporis 1F28.Y Approved [1]
Tinea cruris 1F28.3 Approved [1]
Tinea versicolor 1F2D.0 Approved [1]
Tinea pedis 1F28.2 Investigative [1]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Antifungal Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 344.8
Logarithm of the Partition Coefficient (xlogp) 5
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 1
ADMET Property
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [3]
Elimination
5% of drug is excreted from urine in the unchanged form [3]
Metabolism
The drug is metabolized via the hepatic [4]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 2.0713 micromolar/kg/day [5]
Water Solubility
The ability of drug to dissolve in water is measured as 0.003 mg/mL [3]
Chemical Identifiers
Formula
C22H17ClN2
IUPAC Name
1-[(2-chlorophenyl)-diphenylmethyl]imidazole
Canonical SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4
InChI
InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChIKey
VNFPBHJOKIVQEB-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
2812
ChEBI ID
CHEBI:3764
CAS Number
23593-75-1
DrugBank ID
DB00257
TTD ID
D09GOS
VARIDT ID
DR00574
INTEDE ID
DR0362
ACDINA ID
D00959
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
C-X-C chemokine receptor type 2 (CXCR2) TT30C9G CXCR2_HUMAN Modulator [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Adenylate cyclase type 9 (ADCY9) OT1IZT5K ADCY9_HUMAN Gene/Protein Processing [8]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Gene/Protein Processing [9]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Gene/Protein Processing [10]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Gene/Protein Processing [11]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Gene/Protein Processing [12]
ATP-dependent 6-phosphofructokinase, muscle type (PFKM) OT1QY9JM PFKAM_HUMAN Gene/Protein Processing [13]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [14]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [15]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [16]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Gene/Protein Processing [12]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Cutaneous candidiasis
ICD Disease Classification 1F23.14
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
C-X-C chemokine receptor type 2 (CXCR2) DTT CXCR2 8.82E-01 -0.23 -0.21
C-X-C chemokine receptor type 2 (CXCR2) DTT CXCR2 1.34E-01 0.21 0.19
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 2.13E-01 4.03E-02 2.50E-01
Cytochrome P450 3A4 (CYP3A4) DME CYP3A4 8.21E-02 8.17E-02 4.35E-01
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Clotrimazole (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Remdesivir DMBFZ6L Moderate Increased risk of hepatotoxicity by the combination of Clotrimazole and Remdesivir. 1D6YCoronavirus Disease 2019 [1D6YCoronavirus Disease 2019] [17]
Methylergonovine DMBEX4O Moderate Decreased metabolism of Clotrimazole caused by Methylergonovine mediated inhibition of CYP450 enzyme. Abortion [JA00] [18]
Repaglinide DM5SXUV Moderate Decreased metabolism of Clotrimazole caused by Repaglinide mediated inhibition of CYP450 enzyme. Acute diabete complication [5A2Y] [19]
Thioguanine DM7NKEV Moderate Increased risk of hepatotoxicity by the combination of Clotrimazole and Thioguanine. Acute myeloid leukaemia [2A60] [20]
Gilteritinib DMTI0ZO Moderate Decreased metabolism of Clotrimazole caused by Gilteritinib mediated inhibition of CYP450 enzyme. Acute myeloid leukaemia [2A60] [21]
Terfenadine DM4KLPT Major Decreased metabolism of Clotrimazole caused by Terfenadine mediated inhibition of CYP450 enzyme. Allergic/hypersensitivity disorder [4A80-4A8Z] [22]
Donepezil DMIYG7Z Minor Decreased metabolism of Clotrimazole caused by Donepezil mediated inhibition of CYP450 enzyme. Alzheimer disease [8A20] [23]
Ivabradine DM0L594 Major Decreased metabolism of Clotrimazole caused by Ivabradine mediated inhibition of CYP450 enzyme. Angina pectoris [BA40] [21]
Bepridil DM0RKS4 Moderate Decreased metabolism of Clotrimazole caused by Bepridil mediated inhibition of CYP450 enzyme. Angina pectoris [BA40] [24]
Dronedarone DMA8FS5 Moderate Decreased metabolism of Clotrimazole caused by Dronedarone mediated inhibition of CYP450 enzyme. Angina pectoris [BA40] [25]
Nifedipine DMSVOZT Moderate Decreased metabolism of Clotrimazole caused by Nifedipine mediated inhibition of CYP450 enzyme. Angina pectoris [BA40] [24]
Bedaquiline DM3906J Moderate Increased risk of hepatotoxicity by the combination of Clotrimazole and Bedaquiline. Antimicrobial drug resistance [MG50-MG52] [26]
Alprazolam DMC7XDN Moderate Decreased metabolism of Clotrimazole caused by Alprazolam mediated inhibition of CYP450 enzyme. Anxiety disorder [6B00-6B0Z] [27]
Cilostazol DMZMSCT Moderate Decreased metabolism of Clotrimazole caused by Cilostazol mediated inhibition of CYP450 enzyme. Arterial occlusive disease [BD40] [28]
Budesonide DMJIBAW Moderate Decreased metabolism of Clotrimazole caused by Budesonide mediated inhibition of CYP450 enzyme. Asthma [CA23] [29]
Pimecrolimus DMZLGRB Minor Decreased metabolism of Clotrimazole caused by Pimecrolimus mediated inhibition of CYP450 enzyme. Atopic eczema [EA80] [30]
Cariprazine DMJYDVK Moderate Decreased metabolism of Clotrimazole caused by Cariprazine mediated inhibition of CYP450 enzyme. Bipolar disorder [6A60] [21]
Pexidartinib DMS2J0Z Major Increased risk of hepatotoxicity by the combination of Clotrimazole and Pexidartinib. Bone/articular cartilage neoplasm [2F7B] [31]
Ixabepilone DM2OZ3G Moderate Decreased metabolism of Clotrimazole caused by Ixabepilone mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [32]
Lapatinib DM3BH1Y Moderate Decreased metabolism of Clotrimazole caused by Lapatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [33]
HKI-272 DM6QOVN Major Decreased metabolism of Clotrimazole caused by HKI-272 mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [34]
LY2835219 DM93VBZ Moderate Decreased metabolism of Clotrimazole caused by LY2835219 mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [35]
Esterified estrogens DM9KZDO Moderate Decreased metabolism of Clotrimazole caused by Esterified estrogens mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [36]
Palbociclib DMD7L94 Moderate Decreased metabolism of Clotrimazole caused by Palbociclib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [21]
Quinestrol DMJ6H1Z Moderate Decreased metabolism of Clotrimazole caused by Quinestrol mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [36]
Cabazitaxel DMPAZHC Moderate Decreased metabolism of Clotrimazole caused by Cabazitaxel mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [37]
Toremifene DMQYUWG Moderate Decreased metabolism of Clotrimazole caused by Toremifene mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [38]
Bosutinib DMTI8YE Moderate Decreased metabolism of Clotrimazole caused by Bosutinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [21]
Estradiol DMUNTE3 Moderate Decreased metabolism of Clotrimazole caused by Estradiol mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [36]
Atorvastatin DMF28YC Moderate Decreased metabolism of Clotrimazole caused by Atorvastatin mediated inhibition of CYP450 enzyme. Cardiovascular disease [BA00-BE2Z] [21]
Macitentan DMP79A1 Moderate Decreased metabolism of Clotrimazole caused by Macitentan mediated inhibition of CYP450 enzyme. Cardiovascular disease [BA00-BE2Z] [39]
PF-04449913 DMSB068 Moderate Decreased metabolism of Clotrimazole caused by PF-04449913 mediated inhibition of CYP450 enzyme. Chronic myelomonocytic leukaemia [2A40] [40]
Indacaterol DMQJHR7 Minor Decreased metabolism of Clotrimazole caused by Indacaterol mediated inhibition of CYP450 enzyme. Chronic obstructive pulmonary disease [CA22] [41]
Drospirenone DM1A9W3 Moderate Decreased metabolism of Clotrimazole caused by Drospirenone mediated inhibition of CYP450 enzyme. Contraceptive management [QA21] [36]
Levonorgestrel DM1DP7T Moderate Decreased metabolism of Clotrimazole caused by Levonorgestrel mediated inhibition of CYP450 enzyme. Contraceptive management [QA21] [36]
Ulipristal DMBNI20 Minor Decreased metabolism of Clotrimazole caused by Ulipristal mediated inhibition of CYP450 enzyme. Contraceptive management [QA21] [21]
Etonogestrel DMKA8J4 Moderate Decreased metabolism of Clotrimazole caused by Etonogestrel mediated inhibition of CYP450 enzyme. Contraceptive management [QA21] [36]
Levobupivacaine DM783CH Moderate Decreased metabolism of Clotrimazole caused by Levobupivacaine mediated inhibition of CYP450 enzyme. Corneal disease [9A76-9A78] [21]
Ropivacaine DMSPJG2 Minor Decreased metabolism of Clotrimazole caused by Ropivacaine mediated inhibition of CYP450 enzyme. Corneal disease [9A76-9A78] [42]
Alfentanil DMVO0UB Major Decreased metabolism of Clotrimazole caused by Alfentanil mediated inhibition of CYP450 enzyme. Corneal disease [9A76-9A78] [43]
Nimodipine DMQ0RKZ Moderate Decreased metabolism of Clotrimazole caused by Nimodipine mediated inhibition of CYP450 enzyme. Coronary vasospastic disease [BA85] [24]
Methadone DMTW6IU Moderate Decreased metabolism of Clotrimazole caused by Methadone mediated inhibition of CYP450 enzyme. Cough [MD12] [44]
Ivacaftor DMZC1HS Moderate Decreased metabolism of Clotrimazole caused by Ivacaftor mediated inhibition of CYP450 enzyme. Cystic fibrosis [CA25] [45]
Rivaroxaban DMQMBZ1 Moderate Decreased metabolism of Clotrimazole caused by Rivaroxaban mediated inhibition of CYP450 enzyme. Deep vein thrombosis [BD71] [17]
Aprepitant DM053KT Moderate Decreased metabolism of Clotrimazole caused by Aprepitant mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [46]
Vilazodone DM4LECQ Moderate Decreased metabolism of Clotrimazole caused by Vilazodone mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [47]
Escitalopram DMFK9HG Minor Decreased metabolism of Clotrimazole caused by Escitalopram mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [48]
OPC-34712 DMHG57U Major Decreased metabolism of Clotrimazole caused by OPC-34712 mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [49]
Venlafaxine DMR6QH0 Moderate Decreased metabolism of Clotrimazole caused by Venlafaxine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [17]
Polatuzumab vedotin DMF6Y0L Moderate Decreased metabolism of Clotrimazole caused by Polatuzumab vedotin mediated inhibition of CYP450 enzyme. Diffuse large B-cell lymphoma [2A81] [50]
[3H]estrone-3-sulphate DMGPF0N Moderate Decreased metabolism of Clotrimazole caused by [3H]estrone-3-sulphate mediated inhibition of CYP450 enzyme. Discovery agent [N.A.] [51]
Ingrezza DMVPLNC Major Additive CNS depression effects by the combination of Clotrimazole and Ingrezza. Dystonic disorder [8A02] [52]
Diazepam DM08E9O Moderate Decreased metabolism of Clotrimazole caused by Diazepam mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [53]
Zonisamide DM0DTF7 Moderate Decreased metabolism of Clotrimazole caused by Zonisamide mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [54]
Stiripentol DMMSDOY Moderate Decreased metabolism of Clotrimazole caused by Stiripentol mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [21]
Cannabidiol DM0659E Moderate Increased risk of hepatotoxicity by the combination of Clotrimazole and Cannabidiol. Epileptic encephalopathy [8A62] [21]
Nicardipine DMCDYW7 Moderate Decreased metabolism of Clotrimazole caused by Nicardipine mediated inhibition of CYP450 enzyme. Essential hypertension [BA00] [24]
Bay 80-6946 DMLOS5R Moderate Decreased metabolism of Clotrimazole caused by Bay 80-6946 mediated inhibition of CYP450 enzyme. Follicular lymphoma [2A80] [55]
Solifenacin DMG592Q Moderate Decreased metabolism of Clotrimazole caused by Solifenacin mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [56]
Mirabegron DMS1GYT Minor Decreased metabolism of Clotrimazole caused by Mirabegron mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [57]
Tolterodine DMSHPW8 Moderate Decreased metabolism of Clotrimazole caused by Tolterodine mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [58]
Darifenacin DMWXLYZ Moderate Decreased metabolism of Clotrimazole caused by Darifenacin mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [59]
Cisapride DMY7PED Moderate Decreased metabolism of Clotrimazole caused by Cisapride mediated inhibition of CYP450 enzyme. Gastro-oesophageal reflux disease [DA22] [60]
Ripretinib DM958QB Moderate Decreased metabolism of Clotrimazole caused by Ripretinib mediated inhibition of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [17]
Avapritinib DMK2GZX Moderate Decreased metabolism of Clotrimazole caused by Avapritinib mediated inhibition of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [21]
Ergotamine DMKR3C5 Moderate Decreased metabolism of Clotrimazole caused by Ergotamine mediated inhibition of CYP450 enzyme. Headache [8A80-8A84] [61]
Eplerenone DMF0NQR Major Decreased metabolism of Clotrimazole caused by Eplerenone mediated inhibition of CYP450 enzyme. Heart failure [BD10-BD1Z] [62]
Boceprevir DMBSHMF Moderate Decreased metabolism of Clotrimazole caused by Boceprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [63]
Telaprevir DMMRV29 Moderate Decreased metabolism of Clotrimazole caused by Telaprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [63]
Daclatasvir DMSFK9V Moderate Decreased metabolism of Clotrimazole caused by Daclatasvir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [17]
Brentuximab vedotin DMWLC57 Moderate Increased risk of hepatotoxicity by the combination of Clotrimazole and Brentuximab vedotin. Hodgkin lymphoma [2B30] [64]
MK-1439 DM215WE Minor Decreased metabolism of Clotrimazole caused by MK-1439 mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [65]
Cobicistat DM6L4H2 Moderate Decreased metabolism of Clotrimazole caused by Cobicistat mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [66]
Efavirenz DMC0GSJ Moderate Increased risk of hepatotoxicity by the combination of Clotrimazole and Efavirenz. Human immunodeficiency virus disease [1C60-1C62] [67]
Dolutegravir DMCZGRE Minor Decreased metabolism of Clotrimazole caused by Dolutegravir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [68]
Etravirine DMGV8QU Moderate Decreased metabolism of Clotrimazole caused by Etravirine mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [69]
Lopinavir DMITQS0 Minor Decreased metabolism of Clotrimazole caused by Lopinavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [21]
Rilpivirine DMJ0QOW Moderate Decreased metabolism of Clotrimazole caused by Rilpivirine mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [17]
Amprenavir DMLMXE0 Minor Decreased metabolism of Clotrimazole caused by Amprenavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [70]
Atazanavir DMSYRBX Moderate Decreased metabolism of Clotrimazole caused by Atazanavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [71]
Maraviroc DMTL94F Moderate Decreased metabolism of Clotrimazole caused by Maraviroc mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [72]
Simvastatin DM30SGU Moderate Decreased metabolism of Clotrimazole caused by Simvastatin mediated inhibition of CYP450 enzyme. Hyper-lipoproteinaemia [5C80] [21]
Mipomersen DMGSRN1 Major Increased risk of hepatotoxicity by the combination of Clotrimazole and Mipomersen. Hyper-lipoproteinaemia [5C80] [73]
Teriflunomide DMQ2FKJ Major Increased risk of hepatotoxicity by the combination of Clotrimazole and Teriflunomide. Hyper-lipoproteinaemia [5C80] [74]
BMS-201038 DMQTAGO Major Increased risk of hepatotoxicity by the combination of Clotrimazole and BMS-201038. Hyper-lipoproteinaemia [5C80] [75]
Cerivastatin DMXCM7H Moderate Decreased metabolism of Clotrimazole caused by Cerivastatin mediated inhibition of CYP450 enzyme. Hyper-lipoproteinaemia [5C80] [21]
Aliskiren DM1BV7W Moderate Decreased metabolism of Clotrimazole caused by Aliskiren mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [74]
Nisoldipine DM7ISKJ Moderate Decreased metabolism of Clotrimazole caused by Nisoldipine mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [24]
Levamlodipine DM92S6N Moderate Decreased metabolism of Clotrimazole caused by Levamlodipine mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [24]
Isradipine DMA5XGH Moderate Decreased metabolism of Clotrimazole caused by Isradipine mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [24]
Verapamil DMA7PEW Moderate Decreased metabolism of Clotrimazole caused by Verapamil mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [24]
Diltiazem DMAI7ZV Moderate Decreased metabolism of Clotrimazole caused by Diltiazem mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [24]
Amlodipine DMBDAZV Moderate Decreased metabolism of Clotrimazole caused by Amlodipine mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [24]
Felodipine DMOSW35 Moderate Decreased metabolism of Clotrimazole caused by Felodipine mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [24]
Retapamulin DM9JXB7 Minor Decreased metabolism of Clotrimazole caused by Retapamulin mediated inhibition of CYP450 enzyme. Impetigo [1B72] [76]
Suvorexant DM0E6S3 Moderate Decreased metabolism of Clotrimazole caused by Suvorexant mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [17]
Eszopiclone DM8RZ9H Moderate Decreased metabolism of Clotrimazole caused by Eszopiclone mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [77]
Triazolam DMETYK5 Moderate Decreased metabolism of Clotrimazole caused by Triazolam mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [27]
Tasimelteon DMLOQ1V Moderate Decreased metabolism of Clotrimazole caused by Tasimelteon mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [78]
ITI-007 DMUQ1DO Moderate Decreased metabolism of Clotrimazole caused by ITI-007 mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [79]
Zolpidem DMWOSKJ Moderate Decreased metabolism of Clotrimazole caused by Zolpidem mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [80]
Methotrexate DM2TEOL Moderate Increased risk of hepatotoxicity by the combination of Clotrimazole and Methotrexate. Leukaemia [2A60-2B33] [21]
Pemigatinib DM819JF Moderate Decreased metabolism of Clotrimazole caused by Pemigatinib mediated inhibition of CYP450 enzyme. Liver cancer [2C12] [21]
Crizotinib DM4F29C Moderate Decreased metabolism of Clotrimazole caused by Crizotinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [81]
Brigatinib DM7W94S Moderate Decreased metabolism of Clotrimazole caused by Brigatinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [17]
Ceritinib DMB920Z Moderate Decreased metabolism of Clotrimazole caused by Ceritinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [82]
Lurbinectedin DMEFRTZ Moderate Decreased metabolism of Clotrimazole caused by Lurbinectedin mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [83]
PF-06463922 DMKM7EW Moderate Decreased metabolism of Clotrimazole caused by PF-06463922 mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [84]
Osimertinib DMRJLAT Moderate Decreased metabolism of Clotrimazole caused by Osimertinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [85]
Pralsetinib DMWU0I2 Moderate Decreased metabolism of Clotrimazole caused by Pralsetinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [86]
Selpercatinib DMZR15V Moderate Decreased metabolism of Clotrimazole caused by Selpercatinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [21]
Halofantrine DMOMK1V Major Decreased metabolism of Clotrimazole caused by Halofantrine mediated inhibition of CYP450 enzyme. Malaria [1F40-1F45] [87]
Quinine DMSWYF5 Moderate Decreased metabolism of Clotrimazole caused by Quinine mediated inhibition of CYP450 enzyme. Malaria [1F40-1F45] [17]
Calaspargase pegol DMQZBXI Moderate Increased risk of hepatotoxicity by the combination of Clotrimazole and Calaspargase pegol. Malignant haematopoietic neoplasm [2B33] [88]
Idelalisib DM602WT Moderate Increased risk of hepatotoxicity by the combination of Clotrimazole and Idelalisib. Mature B-cell leukaemia [2A82] [89]
GDC-0199 DMH0QKA Moderate Decreased metabolism of Clotrimazole caused by GDC-0199 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [17]
IPI-145 DMWA24P Moderate Decreased metabolism of Clotrimazole caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [90]
Acalabrutinib DM7GCVW Moderate Decreased metabolism of Clotrimazole caused by Acalabrutinib mediated inhibition of CYP450 enzyme. Mature B-cell lymphoma [2A85] [91]
Clofarabine DMCVJ86 Moderate Increased risk of hepatotoxicity by the combination of Clotrimazole and Clofarabine. Mature B-cell lymphoma [2A85] [92]
Ibrutinib DMHZCPO Moderate Decreased metabolism of Clotrimazole caused by Ibrutinib mediated inhibition of CYP450 enzyme. Mature B-cell lymphoma [2A85] [93]
Ponatinib DMYGJQO Moderate Decreased metabolism of Clotrimazole caused by Ponatinib mediated inhibition of CYP450 enzyme. Mature B-cell lymphoma [2A85] [94]
Selumetinib DMC7W6R Moderate Decreased metabolism of Clotrimazole caused by Selumetinib mediated inhibition of CYP450 enzyme. Melanoma [2C30] [95]
Estrone DM5T6US Moderate Decreased metabolism of Clotrimazole caused by Estrone mediated inhibition of CYP450 enzyme. Menopausal disorder [GA30] [36]
Dienestrol DMBSXI0 Moderate Decreased metabolism of Clotrimazole caused by Dienestrol mediated inhibition of CYP450 enzyme. Menopausal disorder [GA30] [51]
Conjugated estrogens DMLT0E1 Moderate Decreased metabolism of Clotrimazole caused by Conjugated estrogens mediated inhibition of CYP450 enzyme. Menopausal disorder [GA30] [36]
Ethinyl estradiol DMODJ40 Moderate Decreased metabolism of Clotrimazole caused by Ethinyl estradiol mediated inhibition of CYP450 enzyme. Menopausal disorder [GA30] [51]
Nitisinone DMVS9WQ Moderate Decreased metabolism of Clotrimazole caused by Nitisinone mediated inhibition of CYP450 enzyme. Metabolism inborn error [5C50] [74]
Dihydroergotamine DM5IKUF Moderate Decreased metabolism of Clotrimazole caused by Dihydroergotamine mediated inhibition of CYP450 enzyme. Migraine [8A80] [61]
Ubrogepant DM749I3 Moderate Decreased metabolism of Clotrimazole caused by Ubrogepant mediated inhibition of CYP450 enzyme. Migraine [8A80] [96]
Flibanserin DM70DTN Moderate Decreased metabolism of Clotrimazole caused by Flibanserin mediated inhibition of CYP450 enzyme. Mood disorder [6A60-6E23] [97]
Panobinostat DM58WKG Moderate Decreased metabolism of Clotrimazole caused by Panobinostat mediated inhibition of CYP450 enzyme. Multiple myeloma [2A83] [98]
Nilotinib DM7HXWT Moderate Decreased metabolism of Clotrimazole caused by Nilotinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [99]
Ruxolitinib DM7Q98D Minor Decreased metabolism of Clotrimazole caused by Ruxolitinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [21]
Imatinib DM7RJXL Moderate Decreased metabolism of Clotrimazole caused by Imatinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [100]
Dasatinib DMJV2EK Moderate Decreased metabolism of Clotrimazole caused by Dasatinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [101]
Modafinil DMYILBE Minor Decreased metabolism of Clotrimazole caused by Modafinil mediated inhibition of CYP450 enzyme. Narcolepsy [7A20] [17]
Entrectinib DMMPTLH Moderate Decreased metabolism of Clotrimazole caused by Entrectinib mediated inhibition of CYP450 enzyme. Non-small cell lung cancer [2C25] [102]
Sibutramine DMFJTDI Minor Decreased metabolism of Clotrimazole caused by Sibutramine mediated inhibition of CYP450 enzyme. Obesity [5B80-5B81] [103]
Levomethadyl Acetate DM06HG5 Major Decreased metabolism of Clotrimazole caused by Levomethadyl Acetate mediated inhibition of CYP450 enzyme. Opioid use disorder [6C43] [104]
S-297995 DM26IH8 Moderate Decreased metabolism of Clotrimazole caused by S-297995 mediated inhibition of CYP450 enzyme. Opioid use disorder [6C43] [21]
Valdecoxib DMAY7H4 Moderate Decreased metabolism of Clotrimazole caused by Valdecoxib mediated inhibition of CYP450 enzyme. Osteoarthritis [FA00-FA05] [105]
Olaparib DM8QB1D Moderate Decreased metabolism of Clotrimazole caused by Olaparib mediated inhibition of CYP450 enzyme. Ovarian cancer [2C73] [106]
Butorphanol DM5KYPJ Major Decreased metabolism of Clotrimazole caused by Butorphanol mediated inhibition of CYP450 enzyme. Pain [MG30-MG3Z] [107]
Buprenorphine DMPRI8G Moderate Decreased metabolism of Clotrimazole caused by Buprenorphine mediated inhibition of CYP450 enzyme. Pain [MG30-MG3Z] [108]
Hydrocodone DMQ2JO5 Major Decreased metabolism of Clotrimazole caused by Hydrocodone mediated inhibition of CYP450 enzyme. Pain [MG30-MG3Z] [109]
Oxycodone DMXLKHV Major Decreased metabolism of Clotrimazole caused by Oxycodone mediated inhibition of CYP450 enzyme. Pain [MG30-MG3Z] [17]
Pimavanserin DMR7IVC Moderate Decreased metabolism of Clotrimazole caused by Pimavanserin mediated inhibition of CYP450 enzyme. Parkinsonism [8A00] [110]
Lefamulin DME6G97 Moderate Decreased metabolism of Clotrimazole caused by Lefamulin mediated inhibition of CYP450 enzyme. Pneumonia [CA40] [111]
Ergonovine DM0VEC1 Moderate Decreased metabolism of Clotrimazole caused by Ergonovine mediated inhibition of CYP450 enzyme. Postpartum haemorrhage [JA43] [18]
Lonafarnib DMGM2Z6 Major Decreased metabolism of Clotrimazole caused by Lonafarnib mediated inhibition of CYP450 enzyme. Premature ageing appearance [LD2B] [112]
Progesterone DMUY35B Moderate Decreased metabolism of Clotrimazole caused by Progesterone mediated inhibition of CYP450 enzyme. Preterm labour/delivery [JB00] [36]
Enzalutamide DMGL19D Moderate Decreased metabolism of Clotrimazole caused by Enzalutamide mediated inhibition of CYP450 enzyme. Prostate cancer [2C82] [113]
Tamsulosin DM5QF9V Moderate Decreased metabolism of Clotrimazole caused by Tamsulosin mediated inhibition of CYP450 enzyme. Prostate hyperplasia [GA90] [114]
Silodosin DMJSBT6 Moderate Decreased metabolism of Clotrimazole caused by Silodosin mediated inhibition of CYP450 enzyme. Prostate hyperplasia [GA90] [115]
Dutasteride DMQ4TJK Moderate Decreased metabolism of Clotrimazole caused by Dutasteride mediated inhibition of CYP450 enzyme. Prostate hyperplasia [GA90] [116]
Alfuzosin DMZVMKF Moderate Decreased metabolism of Clotrimazole caused by Alfuzosin mediated inhibition of CYP450 enzyme. Prostate hyperplasia [GA90] [117]
Bosentan DMIOGBU Moderate Decreased metabolism of Clotrimazole caused by Bosentan mediated inhibition of CYP450 enzyme. Pulmonary hypertension [BB01] [118]
Everolimus DM8X2EH Moderate Decreased metabolism of Clotrimazole caused by Everolimus mediated inhibition of CYP450 enzyme. Renal cell carcinoma [2C90] [119]
Axitinib DMGVH6N Moderate Decreased metabolism of Clotrimazole caused by Axitinib mediated inhibition of CYP450 enzyme. Renal cell carcinoma [2C90] [21]
Temsirolimus DMS104F Moderate Decreased metabolism of Clotrimazole caused by Temsirolimus mediated inhibition of CYP450 enzyme. Renal cell carcinoma [2C90] [120]
Leflunomide DMR8ONJ Major Increased risk of hepatotoxicity by the combination of Clotrimazole and Leflunomide. Rheumatoid arthritis [FA20] [74]
Quetiapine DM1N62C Moderate Decreased metabolism of Clotrimazole caused by Quetiapine mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [121]
Aripiprazole DM3NUMH Moderate Decreased metabolism of Clotrimazole caused by Aripiprazole mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [122]
Pimozide DMW83TP Moderate Decreased metabolism of Clotrimazole caused by Pimozide mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [123]
Fentanyl DM8WAHT Major Decreased metabolism of Clotrimazole caused by Fentanyl mediated inhibition of CYP450 enzyme. Sensation disturbance [MB40] [17]
Tadalafil DMJZHT1 Moderate Decreased metabolism of Clotrimazole caused by Tadalafil mediated inhibition of CYP450 enzyme. Sexual dysfunction [HA00-HA01] [124]
Vardenafil DMTBGW8 Moderate Decreased metabolism of Clotrimazole caused by Vardenafil mediated inhibition of CYP450 enzyme. Sexual dysfunction [HA00-HA01] [125]
LDE225 DMM9F25 Major Decreased metabolism of Clotrimazole caused by LDE225 mediated inhibition of CYP450 enzyme. Skin cancer [2C30-2C37] [126]
Gefitinib DM15F0X Moderate Decreased metabolism of Clotrimazole caused by Gefitinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [127]
Larotrectinib DM26CQR Moderate Decreased metabolism of Clotrimazole caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [17]
Trabectedin DMG3Y89 Moderate Increased risk of hepatotoxicity by the combination of Clotrimazole and Trabectedin. Solid tumour/cancer [2A00-2F9Z] [21]
Armodafinil DMGB035 Minor Decreased metabolism of Clotrimazole caused by Armodafinil mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [17]
LEE011 DMMX75K Moderate Decreased metabolism of Clotrimazole caused by LEE011 mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [17]
Norethindrone DMTY169 Moderate Decreased metabolism of Clotrimazole caused by Norethindrone mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [51]
Taxol DMUOT9V Moderate Decreased metabolism of Clotrimazole caused by Taxol mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [128]
Naltrexone DMUL45H Moderate Increased risk of hepatotoxicity by the combination of Clotrimazole and Naltrexone. Substance abuse [6C40] [129]
Fostamatinib DM6AUHV Moderate Decreased metabolism of Clotrimazole caused by Fostamatinib mediated inhibition of CYP450 enzyme. Thrombocytopenia [3B64] [130]
Apixaban DM89JLN Moderate Decreased metabolism of Clotrimazole caused by Apixaban mediated inhibition of CYP450 enzyme. Thrombosis [DB61-GB90] [21]
Brilinta DMBR01X Moderate Decreased metabolism of Clotrimazole caused by Brilinta mediated inhibition of CYP450 enzyme. Thrombosis [DB61-GB90] [21]
Cabozantinib DMIYDT4 Moderate Decreased metabolism of Clotrimazole caused by Cabozantinib mediated inhibition of CYP450 enzyme. Thyroid cancer [2D10] [131]
Sirolimus DMGW1ID Major Decreased metabolism of Clotrimazole caused by Sirolimus mediated inhibition of CYP450 enzyme. Transplant rejection [NE84] [132]
Tacrolimus DMZ7XNQ Major Decreased metabolism of Clotrimazole caused by Tacrolimus mediated inhibition of CYP450 enzyme. Transplant rejection [NE84] [132]
Saxagliptin DMGXENV Moderate Decreased metabolism of Clotrimazole caused by Saxagliptin mediated inhibition of CYP450 enzyme. Type 2 diabetes mellitus [5A11] [21]
Elagolix DMB2C0E Moderate Decreased metabolism of Clotrimazole caused by Elagolix mediated inhibition of CYP450 enzyme. Uterine fibroid [2E86] [133]
Fexofenadine DM17ONX Minor Decreased clearance of Clotrimazole due to the transporter inhibition by Fexofenadine. Vasomotor/allergic rhinitis [CA08] [134]
Astemizole DM2HN6Q Major Decreased metabolism of Clotrimazole caused by Astemizole mediated inhibition of CYP450 enzyme. Vasomotor/allergic rhinitis [CA08] [22]
Propafenone DMPIBJK Moderate Decreased metabolism of Clotrimazole caused by Propafenone mediated inhibition of CYP450 enzyme. Ventricular tachyarrhythmia [BC71] [135]
Amiodarone DMUTEX3 Major Decreased metabolism of Clotrimazole caused by Amiodarone mediated inhibition of CYP450 enzyme. Ventricular tachyarrhythmia [BC71] [136]
⏷ Show the Full List of 188 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Benzyl alcohol E00010 244 Antimicrobial preservative; Solvent
Cetyl alcohol E00061 2682 Coating agent; Emollient; Emulsifying agent; Stiffening agent
Phosphoric acid E00039 1004 Acidulant; Buffering agent
Propylene glycol E00040 1030 Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Sodium phosphate monobasic monohydrate E00428 516949 Buffering agent; Complexing agent
Stearyl alcohol E00172 8221 Emollient; Emulsifying agent; Stiffening agent; Viscosity-controlling agent
Water E00035 962 Solvent
⏷ Show the Full List of 7 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Clotrimazole eq 0.05% base cream eq 0.05% base Cream Topical
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

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102 Product Information. Rozlytrek (entrectinib). Genentech, South San Francisco, CA.
103 Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
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112 Product Information. Zokinvy (lonafarnib). Eiger BioPharmaceuticals, Palo Alto, CA.
113 Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
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118 Product Information. Tracleer (bosentan). Acetelion Pharmaceuticals US, Inc, South San Francisco, CA.
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130 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
131 Product Information. Cometriq (cabozantinib). Exelixis Inc, S San Francisco, CA.
132 Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
133 Product Information. Orilissa (elagolix). AbbVie US LLC, North Chicago, IL.
134 Product Information. Allegra (fexofenadine). Hoechst Marion-Roussel Inc, Kansas City, MO.
135 Product Information. Rythmol SR (propafenone). GlaxoSmithKline, Research Triangle Park, NC.
136 Fabre G, Julian B, Saint-Aubert B, Joyeux H, Berger Y "Evidence for CYP3A-mediated N-deethylation of amiodarone in human liver microsomal fractions." Drug Metab Dispos 21 (1993): 978-85. [PMID: 7905403]