Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9WIHJ)

Drug Name

NSC-88915 Drug Info

Synonyms

3,20-dioxopregn-4-en-21-yl 4-bromobenzenesulfonate; NSC-88915; 21170-34-3; NSC88915; CHEMBL387152; AC1L60NG; AC1Q267H; SCHEMBL13856957; CTK1A5243; ZINC4901407; BDBM50158383; AKOS028112969; NCI60_041972; 170D343; 4-pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate); Pregn-4-ene-3,20-dione, 21-[[(4-bromophenyl)sulfonyl]oxy]-; 2-((8S,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl 4-bromobenzenesulfonate

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Investigative	[1]

Cross-matching ID

PubChem CID: 259210
CAS Number: CAS 21170-34-3
TTD Drug ID: DM9WIHJ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Phosphoribosylaminoimidazolecarboxamide formyltransferase (ATIC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NSC-292213	DMNUSKT	Discovery agent	N.A.	Investigative	[2]
NSC-30171	DMFBZEI	Discovery agent	N.A.	Investigative	[2]
NSC-45592	DMQ6GBX	Discovery agent	N.A.	Investigative	[2]
NSC-47729	DMRZJL1	Discovery agent	N.A.	Investigative	[2]
NSC-26699	DM4RPBJ	Discovery agent	N.A.	Investigative	[2]
NSC-37173	DMZFULS	Discovery agent	N.A.	Investigative	[2]
NSC-58046	DMI6WA7	Discovery agent	N.A.	Investigative	[2]
NSC-37031	DMLY6WX	Discovery agent	N.A.	Investigative	[2]
NSC-324572	DMN50OT	Discovery agent	N.A.	Investigative	[2]
NSC-126445	DMHGIB1	Discovery agent	N.A.	Investigative	[2]
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Drug(s) Targeting Rhodopsin (RHO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[4]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[4]
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[4]
Phosphonothreonine	DMTFHPI	Discovery agent	N.A.	Investigative	[4]
Beta-D-Mannose	DMHIG9K	Discovery agent	N.A.	Investigative	[4]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[4]
Lauryl Dimethylamine-N-Oxide	DM3W2OE	Discovery agent	N.A.	Investigative	[4]
B-2-Octylglucoside	DMEGX8H	Discovery agent	N.A.	Investigative	[4]
(Hydroxyethyloxy)Tri(Ethyloxy)Octane	DMY6FUD	Discovery agent	N.A.	Investigative	[4]
B-Nonylglucoside	DM48VJR	Discovery agent	N.A.	Investigative	[5]
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Drug(s) Targeting Adenylate cyclase (ADCY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ad5-AC6	DMQNFZE	Cardiac failure	BD10-BD13	Terminated	[6]
[3H]cAMP	DMZRQU7	Discovery agent	N.A.	Investigative	[4]
N6-CYCLOPENTYLADENOSINE	DMD6AJO	Discovery agent	N.A.	Investigative	[7]
[3H]alphabeta-meATP	DMWV5C3	Discovery agent	N.A.	Investigative	[4]
2-hydroxy-17beta-estradiol	DMM9Z0B	Discovery agent	N.A.	Investigative	[1]
2,5-didesoxy-3-ATP	DM5CWM0	Discovery agent	N.A.	Investigative	[1]
		N. A.	N. A.		[5]
		N. A.	N. A.		[5]
		N. A.	N. A.		[5]
		N. A.	N. A.		[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenylate cyclase (ADCY)	TT2QM9D	NOUNIPROTAC	Inhibitor	[1]
Phosphoribosylaminoimidazolecarboxamide formyltransferase (ATIC)	TT9NVXQ	PUR9_HUMAN	Inhibitor	[2]
Rhodopsin (RHO)	TTH0KSX	OPSD_HUMAN	Inhibitor	[3]

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References

1	Structure-based development of novel adenylyl cyclase inhibitors. J Med Chem. 2008 Aug 14;51(15):4456-64.
2	Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identif... J Med Chem. 2004 Dec 30;47(27):6681-90.
3	Modulating G-protein coupled receptor/G-protein signal transduction by small molecules suggested by virtual screening. J Med Chem. 2008 Sep 11;51(17):5297-303.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
6	Unanticipated Signaling Events Associated with Cardiac Adenylyl Cyclase Gene Transfer. J Mol Cell Cardiol. 2011 May; 50(5): 751-758.
7	Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors. J Med Chem. 1991 Dec;34(12):3388-90.