Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA93D8)

Drug Name

AC-260584 Drug Info

Synonyms

UNII-M4PN46N313; AC260584; AC-260584; CHEMBL2022960; M4PN46N313; 560083-42-3; 4-(3-(4-Butylpiperidin-1-yl)propyl)-7-fluoro-4H-benzo(1,4)oxazin-3-one; 4-[3-(4-Butylpiperidin-1-yl)propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one; BWAKMLKESHKOHK-UHFFFAOYSA-N; GTPL334; SCHEMBL4069821; BDBM50382122; ZINC34033125; CS-6425; 2H-1,4-Benzoxazin-3(4H)-one, 4-(3-(4-butyl-1-piperidinyl)propyl)-7-fluoro-; AC 260584; HY-100336; 4-[3-(4-butylpiperidin-1-yl)propyl]-7-fluoro-1,4-benzoxazin-3-one

Indication

Disease Entry	ICD 11	Status	REF
Schizophrenia	6A20	Terminated	[1]

Cross-matching ID

PubChem CID: 9928284
CAS Number: CAS 560083-42-3
TTD Drug ID: DMA93D8

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Muscarinic acetylcholine receptor M1 (CHRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ACECLIDINE	DMOLNCZ	Glaucoma/ocular hypertension	9C61	Approved	[3]
Fesoterodine fumarate	DM13495	Overactive bladder	GC50.0	Approved	[4]
SMT-D002	DM1I93C	Seborrhea	ED91.2	Approved	[5]
Clidinium	DMUMQZ0	Abdominal stomach pain	DD91.4	Approved	[6]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[7]
Oxyphenonium	DMMQHOZ	Visceral spasms	MD81.4	Approved	[8]
Benztropine	DMGZOVN	Parkinson disease	8A00.0	Approved	[9]
Glycopyrrolate	DM2M3ZA	Anaesthesia	9A78.6	Approved	[10]
Pirenzepine	DMP6M1N	Peptic ulcer	DA61	Approved	[11]
Cycrimine	DM8C43Q	Parkinson disease	8A00.0	Approved	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor M1 (CHRM1)	TTZ9SOR	ACM1_HUMAN	Agonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 334).
2	Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists. Eur J Pharmacol. 2009 Mar 1;605(1-3):53-6.
3	Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists. J Med Chem. 1993 Apr 2;36(7):842-7.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
5	Demonstration of bladder selective muscarinic receptor binding by intravesical oxybutynin to treat overactive bladder. J Urol. 2004 Nov;172(5 Pt 1):2059-64.
6	Accidental acute clidinium toxicity. Emerg Med J. 2009 Jun;26(6):460.
7	The role of M1 muscarinic cholinergic receptors in the discriminative stimulus properties of N-desmethylclozapine and the atypical antipsychotic dr... Psychopharmacology (Berl). 2009 Apr;203(2):295-301.
8	Ultraviolet spectroscopic estimation of microenvironments and bitter tastes of oxyphenonium bromide in cyclodextrin solutions. J Pharm Sci. 1999 Aug;88(8):759-62.
9	Formulation and biopharmaceutical evaluation of transdermal patch containing benztropine. Int J Pharm. 2008 Jun 5;357(1-2):55-60.
10	Autonomic cardiovascular control during a novel pharmacologic alternative to ganglionic blockade. Clin Pharmacol Ther. 2008 May;83(5):692-701.
11	Negative crosstalk between M1 and M2 muscarinic autoreceptors involves endogenous adenosine activating A1 receptors at the rat motor endplate. Neurosci Lett. 2009 Aug 14;459(3):127-31.
12	Capillary gas chromatography of trihexyphenidyl, procyclidine and cycrimine in biological fluids. J Chromatogr. 1989 Sep 29;494:135-42.