Details of the Drug

General Information of Drug (ID: DMGZOVN)

• Drug Name: Benztropine
• Synonyms: Akitan; Benzatropina; Benzatropine; Benzatropinum; Benztropinum; Cobrentin; Cogentine; Cogentinol; Benzatropine [INN]; Benzatropine mesilate; Pms Benztropine; Tropine benzohydryl ether; NK 02; Apo-Benztropine; Benzatropina [INN-Spanish]; Benzatropine (INN); Benzatropine [INN:BAN]; Benzatropinum [INN-Latin]; Cogentin (TN); Benzhydryl 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ether; (1R,5R)-3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane; (1r,5r)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane; (3-endo)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane; (3-endo)-3-[(diphenylmethyl)oxy]-8-methyl-8-azabicyclo[3.2.1]octane; (5R)-3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane; 3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane; 3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane; 3alpha-(Diphenylmethoxy)-1alphaH,5alphaH-tropane; 3alpha-(diphenylmethoxy)tropane; 3alpha-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane; 3endo-benzhydryloxytropane; 8-Azabicyclo(3.2.1)octane, 3-(diphenylmethoxy)-8-methyl-, endo-(9CI)

Indication

Disease Entry	ICD 11	Status	REF
Parkinson disease	8A00.0	Approved	[1]

• Therapeutic Class: Antiparkinson Agents
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 307.4
  Logarithm of the Partition Coefficient (xlogp); 4.5
  Rotatable Bond Count (rotbonds); 4
  Hydrogen Bond Donor Count (hbonddonor); 0
  Hydrogen Bond Acceptor Count (hbondacc); 2
• ADMET Property:
  BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [2]
  MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 0.2124 micromolar/kg/day [3]
• Chemical Identifiers:
  Formula: C21H25NO
  IUPAC Name: (1R,5S)-3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane
  Canonical SMILES: CN1[C@@H]2CC[C@H]1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4
  InChI: InChI=1S/C21H25NO/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-21H,12-15H2,1H3/t18-,19+,20?
  InChIKey: GIJXKZJWITVLHI-YOFSQIOKSA-N
• Cross-matching ID:
  PubChem CID: 1201549
  ChEBI ID: CHEBI:3048
  CAS Number: 86-13-5
  DrugBank ID: DB00245
  TTD ID: D0HQ6N
  VARIDT ID: DR01328
  ACDINA ID: D00064

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor M1 (CHRM1)	TTZ9SOR	ACM1_HUMAN	Antagonist	[4]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Sodium-dependent dopamine transporter (SLC6A3)	DT3BA8L	SC6A3_HUMAN	Substrate	[5]

Molecular Expression Atlas of This Drug

• The Studied Disease: Parkinson disease
• ICD Disease Classification: 8A00.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Muscarinic acetylcholine receptor M1 (CHRM1)	DTT	CHRM1	5.59E-01	0.19	0.41
Sodium-dependent dopamine transporter (SLC6A3)	DTP	DAT1	1.08E-03	-3.08E+00	-1.99E+00

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Benztropine

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
Biperiden	DME78OA	Moderate	Additive anticholinergic effects by the combination of Benztropine and Biperiden.	Parkinsonism [8A00]	[6]
Procyclidine	DMHFJDT	Moderate	Additive anticholinergic effects by the combination of Benztropine and Procyclidine.	Parkinsonism [8A00]	[6]
Levodopa	DMN3E57	Moderate	Altered absorption of Benztropine due to GI dynamics variation caused by Levodopa.	Parkinsonism [8A00]	[7]
Orphenadrine	DMW542E	Moderate	Additive anticholinergic effects by the combination of Benztropine and Orphenadrine.	Parkinsonism [8A00]	[6]

Coadministration of a Drug Treating the Disease Different from Benztropine (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Bethanechol	DMCLHO0	Moderate	Antagonize the effect of Benztropine when combined with Bethanechol.	Abnormal micturition [MF50]	[8]
Oliceridine	DM6MDCF	Moderate	Additive CNS depression effects by the combination of Benztropine and Oliceridine.	Acute pain [MG31]	[9]
Scopolamine	DMOM8AL	Moderate	Additive anticholinergic effects by the combination of Benztropine and Scopolamine.	Addictive disorder [6C50-6C5Z]	[6]
Mepyramine	DMB4SFH	Moderate	Additive anticholinergic effects by the combination of Benztropine and Mepyramine.	Allergic/hypersensitivity disorder [4A80-4A8Z]	[6]
Phenyltoloxamine	DMKAEQW	Moderate	Additive anticholinergic effects by the combination of Benztropine and Phenyltoloxamine.	Allergic/hypersensitivity disorder [4A80-4A8Z]	[6]
Tripelennamine	DMZBU15	Moderate	Additive anticholinergic effects by the combination of Benztropine and Tripelennamine.	Allergic/hypersensitivity disorder [4A80-4A8Z]	[6]
Tacrine	DM51FY6	Moderate	Antagonize the effect of Benztropine when combined with Tacrine.	Alzheimer disease [8A20]	[10]
Memantine	DMD9WSC	Moderate	Additive anticholinergic effects by the combination of Benztropine and Memantine.	Alzheimer disease [8A20]	[6]
Galantamine	DMEO794	Moderate	Antagonize the effect of Benztropine when combined with Galantamine.	Alzheimer disease [8A20]	[10]
Rivastigmine	DMG629M	Moderate	Antagonize the effect of Benztropine when combined with Rivastigmine.	Alzheimer disease [8A20]	[10]
Donepezil	DMIYG7Z	Moderate	Antagonize the effect of Benztropine when combined with Donepezil.	Alzheimer disease [8A20]	[10]
Marinol	DM70IK5	Moderate	Additive CNS depression effects by the combination of Benztropine and Marinol.	Anorexia nervosa [6B80]	[9]
Methylphenobarbital	DMDSWAG	Moderate	Additive CNS depression effects by the combination of Benztropine and Methylphenobarbital.	Anxiety disorder [6B00-6B0Z]	[9]
Hydroxyzine	DMF8Y74	Moderate	Additive anticholinergic effects by the combination of Benztropine and Hydroxyzine.	Anxiety disorder [6B00-6B0Z]	[6]
Promazine	DMZAL7W	Moderate	Antagonize the effect of Benztropine when combined with Promazine.	Appearance/behaviour symptom [MB23]	[11]
Cariprazine	DMJYDVK	Moderate	Additive anticholinergic effects by the combination of Benztropine and Cariprazine.	Bipolar disorder [6A60]	[6]
Loperamide	DMOJZQ9	Moderate	Additive antimotility effects by the combination of Benztropine and Loperamide.	Bowel habit change [ME05]	[12]
Sotalol	DML60TN	Moderate	Antagonize the effect of Benztropine when combined with Sotalol.	Cardiac arrhythmia [BC9Z]	[13]
Acetylcholine	DMDF79Z	Moderate	Antagonize the effect of Benztropine when combined with Acetylcholine.	Cataract [9B10]	[14]
Secobarbital	DM14RF5	Moderate	Additive CNS depression effects by the combination of Benztropine and Secobarbital.	Chronic insomnia [7A00]	[9]
Umeclidinium	DM4E8O9	Moderate	Additive anticholinergic effects by the combination of Benztropine and Umeclidinium.	Chronic obstructive pulmonary disease [CA22]	[15]
Tiotropium	DMFDC0Q	Moderate	Additive anticholinergic effects by the combination of Benztropine and Tiotropium.	Chronic obstructive pulmonary disease [CA22]	[15]
Ipratropium	DMFQ320	Moderate	Additive anticholinergic effects by the combination of Benztropine and Ipratropium.	Chronic obstructive pulmonary disease [CA22]	[15]
Revefenacin	DMMP5SI	Moderate	Additive anticholinergic effects by the combination of Benztropine and Revefenacin.	Chronic obstructive pulmonary disease [CA22]	[15]
Dihydrocodeine	DMB0FWL	Moderate	Additive CNS depression effects by the combination of Benztropine and Dihydrocodeine.	Chronic pain [MG30]	[9]
Morphine	DMRMS0L	Moderate	Additive CNS depression effects by the combination of Benztropine and Morphine.	Chronic pain [MG30]	[9]
Olopatadine	DMKMWQG	Moderate	Additive CNS depression effects by the combination of Benztropine and Olopatadine.	Conjunctiva disorder [9A60]	[16]
Methohexital	DM7YMIT	Moderate	Additive CNS depression effects by the combination of Benztropine and Methohexital.	Corneal disease [9A76-9A78]	[9]
Thiopental	DMGP8AX	Moderate	Additive CNS depression effects by the combination of Benztropine and Thiopental.	Corneal disease [9A76-9A78]	[9]
Alfentanil	DMVO0UB	Moderate	Additive CNS depression effects by the combination of Benztropine and Alfentanil.	Corneal disease [9A76-9A78]	[9]
Remifentanil	DMZTXCH	Moderate	Additive CNS depression effects by the combination of Benztropine and Remifentanil.	Corneal disease [9A76-9A78]	[9]
Arbutamine	DMCY8AF	Moderate	Increased risk of rapid heart rate by the combination of Benztropine and Arbutamine.	Coronary atherosclerosis [BA80]	[17]
Methadone	DMTW6IU	Moderate	Additive CNS depression effects by the combination of Benztropine and Methadone.	Cough [MD12]	[9]
Ethanol	DMDRQZU	Moderate	Additive CNS depression effects by the combination of Benztropine and Ethanol.	Cystitis [GC00]	[18]
Trimipramine	DM1SC8M	Moderate	Additive anticholinergic effects by the combination of Benztropine and Trimipramine.	Depression [6A70-6A7Z]	[6]
Cyclobenzaprine	DM1YBRM	Moderate	Additive anticholinergic effects by the combination of Benztropine and Cyclobenzaprine.	Depression [6A70-6A7Z]	[6]
Nortriptyline	DM4KDYJ	Moderate	Additive anticholinergic effects by the combination of Benztropine and Nortriptyline.	Depression [6A70-6A7Z]	[6]
Isocarboxazid	DMAF1NB	Minor	Additive anticholinergic effects by the combination of Benztropine and Isocarboxazid.	Depression [6A70-6A7Z]	[9]
Tranylcypromine	DMGB5RE	Minor	Additive anticholinergic effects by the combination of Benztropine and Tranylcypromine.	Depression [6A70-6A7Z]	[9]
OPC-34712	DMHG57U	Moderate	Antagonize the effect of Benztropine when combined with OPC-34712.	Depression [6A70-6A7Z]	[11]
Phenelzine	DMHIDUE	Minor	Additive anticholinergic effects by the combination of Benztropine and Phenelzine.	Depression [6A70-6A7Z]	[9]
Clomipramine	DMINRKW	Moderate	Additive anticholinergic effects by the combination of Benztropine and Clomipramine.	Depression [6A70-6A7Z]	[6]
Amitriptyline	DMK7F9S	Moderate	Additive anticholinergic effects by the combination of Benztropine and Amitriptyline.	Depression [6A70-6A7Z]	[6]
Amoxapine	DMKITQE	Moderate	Additive anticholinergic effects by the combination of Benztropine and Amoxapine.	Depression [6A70-6A7Z]	[6]
Protriptyline	DMNHTZI	Moderate	Additive anticholinergic effects by the combination of Benztropine and Protriptyline.	Depression [6A70-6A7Z]	[6]
Doxepin	DMPI98T	Moderate	Additive anticholinergic effects by the combination of Benztropine and Doxepin.	Depression [6A70-6A7Z]	[6]
Maprotiline	DMPWB7T	Moderate	Additive anticholinergic effects by the combination of Benztropine and Maprotiline.	Depression [6A70-6A7Z]	[6]
Esketamine	DMVU687	Moderate	Additive CNS depression effects by the combination of Benztropine and Esketamine.	Depression [6A70-6A7Z]	[16]
Nitroglycerin	DMQ2491	Minor	Decreased dissolution of Benztropine taken sublingually caused by Nitroglycerin.	Diabetic foot ulcer [BD54]	[19]
Hyoscyamine	DM804UR	Moderate	Additive anticholinergic effects by the combination of Benztropine and Hyoscyamine.	Digestive system disease [DE2Z]	[6]
Mepenzolate	DM8YU2F	Moderate	Additive anticholinergic effects by the combination of Benztropine and Mepenzolate.	Digestive system disease [DE2Z]	[6]
Oxybutynine	DMJPBAX	Moderate	Additive anticholinergic effects by the combination of Benztropine and Oxybutynine.	Discovery agent [N.A.]	[6]
Heroin diacetylmorphine	DMDBWHY	Moderate	Additive CNS depression effects by the combination of Benztropine and Heroin diacetylmorphine.	Dissociative neurological symptom disorder [6B60]	[9]
Meclizine	DMS7T13	Moderate	Additive anticholinergic effects by the combination of Benztropine and Meclizine.	Dizziness and giddiness [MB48]	[6]
Trihexyphenidyl	DMB19L8	Moderate	Additive anticholinergic effects by the combination of Benztropine and Trihexyphenidyl.	Dystonic disorder [8A02]	[6]
Zonisamide	DM0DTF7	Major	Increased risk of hyperpyrexia by the combination of Benztropine and Zonisamide.	Epilepsy/seizure [8A61-8A6Z]	[20]
Primidone	DM0WX6I	Moderate	Additive CNS depression effects by the combination of Benztropine and Primidone.	Epilepsy/seizure [8A61-8A6Z]	[9]
Phenobarbital	DMXZOCG	Moderate	Additive CNS depression effects by the combination of Benztropine and Phenobarbital.	Epilepsy/seizure [8A61-8A6Z]	[9]
Cannabidiol	DM0659E	Moderate	Additive CNS depression effects by the combination of Benztropine and Cannabidiol.	Epileptic encephalopathy [8A62]	[9]
Diphenhydramine	DMKQTBA	Moderate	Additive anticholinergic effects by the combination of Benztropine and Diphenhydramine.	Episodic vestibular syndrome [AB31]	[6]
Timolol	DM3NXRU	Moderate	Antagonize the effect of Benztropine when combined with Timolol.	Essential hypertension [BA00]	[13]
Bendroflumethiazide	DM7EVLC	Minor	Altered absorption of Benztropine due to GI dynamics variation caused by Bendroflumethiazide.	Essential hypertension [BA00]	[21]
Benzthiazide	DMQWZ0H	Minor	Altered absorption of Benztropine due to GI dynamics variation caused by Benzthiazide.	Essential hypertension [BA00]	[21]
Nadolol	DMW6GVL	Moderate	Antagonize the effect of Benztropine when combined with Nadolol.	Essential hypertension [BA00]	[13]
Solifenacin	DMG592Q	Moderate	Additive anticholinergic effects by the combination of Benztropine and Solifenacin.	Functional bladder disorder [GC50]	[6]
Tolterodine	DMSHPW8	Moderate	Additive anticholinergic effects by the combination of Benztropine and Tolterodine.	Functional bladder disorder [GC50]	[6]
Darifenacin	DMWXLYZ	Moderate	Additive anticholinergic effects by the combination of Benztropine and Darifenacin.	Functional bladder disorder [GC50]	[6]
Ketoconazole	DMPZI3Q	Moderate	Decreased absorption of Benztropine due to altered gastric pH caused by Ketoconazole.	Fungal infection [1F29-1F2F]	[22]
Propantheline	DM2EN6G	Moderate	Additive anticholinergic effects by the combination of Benztropine and Propantheline.	Gastric ulcer [DA60]	[6]
Isoflurophate	DMBSK7X	Moderate	Antagonize the effect of Benztropine when combined with Isoflurophate.	Glaucoma [9C61]	[14]
Carteolol	DMFMDOB	Moderate	Antagonize the effect of Benztropine when combined with Carteolol.	Glaucoma [9C61]	[13]
Brimonidine	DMQLT4N	Moderate	Additive CNS depression effects by the combination of Benztropine and Brimonidine.	Glaucoma [9C61]	[23]
Pilocarpine	DMV9ADG	Moderate	Antagonize the effect of Benztropine when combined with Pilocarpine.	Glaucoma [9C61]	[8]
Carvedilol	DMHTEAO	Moderate	Antagonize the effect of Benztropine when combined with Carvedilol.	Heart failure [BD10-BD1Z]	[13]
Chlorothiazide	DMLHESP	Minor	Altered absorption of Benztropine due to GI dynamics variation caused by Chlorothiazide.	Heart failure [BD10-BD1Z]	[21]
Digoxin	DMQCTIH	Minor	Altered absorption of Benztropine due to GI dynamics variation caused by Digoxin.	Heart failure [BD10-BD1Z]	[24]
Hydroflumethiazide	DMVPUQI	Minor	Altered absorption of Benztropine due to GI dynamics variation caused by Hydroflumethiazide.	Heart failure [BD10-BD1Z]	[21]
Acebutolol	DM0TI4U	Moderate	Altered absorption of Benztropine due to GI dynamics variation caused by Acebutolol.	Hypertension [BA00-BA04]	[13]
Bisoprolol	DM3UZ95	Moderate	Altered absorption of Benztropine due to GI dynamics variation caused by Bisoprolol.	Hypertension [BA00-BA04]	[13]
Penbutolol	DM4ES8F	Moderate	Antagonize the effect of Benztropine when combined with Penbutolol.	Hypertension [BA00-BA04]	[13]
Nebivolol	DM7F1PA	Moderate	Antagonize the effect of Benztropine when combined with Nebivolol.	Hypertension [BA00-BA04]	[13]
Pindolol	DMD2NV7	Moderate	Antagonize the effect of Benztropine when combined with Pindolol.	Hypertension [BA00-BA04]	[13]
Indapamide	DMGN1PW	Minor	Altered absorption of Benztropine due to GI dynamics variation caused by Indapamide.	Hypertension [BA00-BA04]	[21]
Trichlormethiazide	DMHAQCO	Minor	Altered absorption of Benztropine due to GI dynamics variation caused by Trichlormethiazide.	Hypertension [BA00-BA04]	[21]
Labetalol	DMK8U72	Moderate	Antagonize the effect of Benztropine when combined with Labetalol.	Hypertension [BA00-BA04]	[25]
Atenolol	DMNKG1Z	Moderate	Antagonize the effect of Benztropine when combined with Atenolol.	Hypertension [BA00-BA04]	[25]
Metoprolol	DMOJ0V6	Moderate	Antagonize the effect of Benztropine when combined with Metoprolol.	Hypertension [BA00-BA04]	[13]
Hydrochlorothiazide	DMUSZHD	Minor	Altered absorption of Benztropine due to GI dynamics variation caused by Hydrochlorothiazide.	Hypertension [BA00-BA04]	[21]
Potassium chloride	DMMTAJC	Major	Altered absorption of Benztropine due to GI dynamics variation caused by Potassium chloride.	Hypo-kalaemia [5C77]	[26]
Belladonna	DM2RBWK	Moderate	Additive anticholinergic effects by the combination of Benztropine and Belladonna.	Infectious gastroenteritis/colitis [1A40]	[6]
Amantadine	DMS3YE9	Moderate	Additive anticholinergic effects by the combination of Benztropine and Amantadine.	Influenza [1E30-1E32]	[27]
Amobarbital	DM0GQ8N	Moderate	Additive CNS depression effects by the combination of Benztropine and Amobarbital.	Insomnia [7A00-7A0Z]	[9]
Pentobarbital	DMFNH7L	Moderate	Additive CNS depression effects by the combination of Benztropine and Pentobarbital.	Insomnia [7A00-7A0Z]	[9]
Propiomazine	DMKY8V1	Moderate	Additive anticholinergic effects by the combination of Benztropine and Propiomazine.	Insomnia [7A00-7A0Z]	[6]
ITI-007	DMUQ1DO	Moderate	Antagonize the effect of Benztropine when combined with ITI-007.	Insomnia [7A00-7A0Z]	[11]
Nabilone	DMVRYT2	Moderate	Additive CNS depression effects by the combination of Benztropine and Nabilone.	Insomnia [7A00-7A0Z]	[9]
R0-93877	DMM4U9G	Moderate	Antagonize the effect of Benztropine when combined with R0-93877.	Irritable bowel syndrome [DD91]	[28]
Clidinium	DMUMQZ0	Moderate	Additive anticholinergic effects by the combination of Benztropine and Clidinium.	Irritable bowel syndrome [DD91]	[6]
Dicyclomine	DMZSDGX	Moderate	Additive anticholinergic effects by the combination of Benztropine and Dicyclomine.	Irritable bowel syndrome [DD91]	[6]
Physostigmine	DM2N0TO	Moderate	Antagonize the effect of Benztropine when combined with Physostigmine.	Lips/oral mucosa miscellaneous disorder [DA02]	[10]
Allopregnanolone	DMNLHAC	Moderate	Additive CNS depression effects by the combination of Benztropine and Allopregnanolone.	Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z]	[13]
Propranolol	DM79NTF	Moderate	Antagonize the effect of Benztropine when combined with Propranolol.	Migraine [8A80]	[13]
Lasmiditan	DMXLVDT	Moderate	Additive CNS depression effects by the combination of Benztropine and Lasmiditan.	Migraine [8A80]	[16]
Flibanserin	DM70DTN	Moderate	Additive CNS depression effects by the combination of Benztropine and Flibanserin.	Mood disorder [6A60-6E23]	[16]
Doxylamine	DMKOXFE	Moderate	Additive anticholinergic effects by the combination of Benztropine and Doxylamine.	Morning sickness disorder [SC00]	[6]
Neostigmine	DM6T2J3	Moderate	Antagonize the effect of Benztropine when combined with Neostigmine.	Myasthenia gravis [8C6Y]	[29]
Pyridostigmine	DM8HO1L	Moderate	Antagonize the effect of Benztropine when combined with Pyridostigmine.	Myasthenia gravis [8C6Y]	[29]
Edrophonium	DMCRQHB	Moderate	Antagonize the effect of Benztropine when combined with Edrophonium.	Myasthenia gravis [8C6Y]	[29]
Ambenonium	DMOP0BL	Moderate	Antagonize the effect of Benztropine when combined with Ambenonium.	Myasthenia gravis [8C6Y]	[29]
Phenindamine	DMDTC7R	Moderate	Additive anticholinergic effects by the combination of Benztropine and Phenindamine.	Nasopharyngitis [CA00]	[6]
Dimenhydrinate	DM264B3	Moderate	Additive anticholinergic effects by the combination of Benztropine and Dimenhydrinate.	Nausea/vomiting [MD90]	[6]
Prochlorperazine	DM53SRA	Moderate	Antagonize the effect of Benztropine when combined with Prochlorperazine.	Nausea/vomiting [MD90]	[11]
Promethazine	DM6I5GR	Moderate	Additive anticholinergic effects by the combination of Benztropine and Promethazine.	Nausea/vomiting [MD90]	[6]
Cyclizine	DM9G7BS	Moderate	Additive anticholinergic effects by the combination of Benztropine and Cyclizine.	Nausea/vomiting [MD90]	[6]
Metoclopramide	DMFA5MY	Moderate	Antagonize the effect of Benztropine when combined with Metoclopramide.	Nausea/vomiting [MD90]	[30]
Thiethylperazine	DMU3IET	Moderate	Additive anticholinergic effects by the combination of Benztropine and Thiethylperazine.	Nausea/vomiting [MD90]	[6]
Chlorthalidone	DM4DMBT	Minor	Altered absorption of Benztropine due to GI dynamics variation caused by Chlorthalidone.	Oedema [MG29]	[21]
Metolazone	DMB39LO	Minor	Altered absorption of Benztropine due to GI dynamics variation caused by Metolazone.	Oedema [MG29]	[21]
Polythiazide	DMCH80F	Minor	Altered absorption of Benztropine due to GI dynamics variation caused by Polythiazide.	Oedema [MG29]	[21]
Levomethadyl Acetate	DM06HG5	Moderate	Additive CNS depression effects by the combination of Benztropine and Levomethadyl Acetate.	Opioid use disorder [6C43]	[9]
Apraclonidine	DMO4PVE	Moderate	Additive CNS depression effects by the combination of Benztropine and Apraclonidine.	Optic nerve disorder [9C40]	[23]
Pentazocine	DM1XBHS	Moderate	Additive CNS depression effects by the combination of Benztropine and Pentazocine.	Pain [MG30-MG3Z]	[9]
Dextropropoxyphene	DM23HCX	Moderate	Additive CNS depression effects by the combination of Benztropine and Dextropropoxyphene.	Pain [MG30-MG3Z]	[9]
Butorphanol	DM5KYPJ	Moderate	Additive CNS depression effects by the combination of Benztropine and Butorphanol.	Pain [MG30-MG3Z]	[9]
Oxymorphone	DM65AGJ	Moderate	Additive CNS depression effects by the combination of Benztropine and Oxymorphone.	Pain [MG30-MG3Z]	[9]
Levorphanol	DMGS80V	Moderate	Additive CNS depression effects by the combination of Benztropine and Levorphanol.	Pain [MG30-MG3Z]	[9]
Hydromorphone	DMHP21E	Moderate	Additive CNS depression effects by the combination of Benztropine and Hydromorphone.	Pain [MG30-MG3Z]	[9]
Dezocine	DMJDB0Y	Moderate	Additive CNS depression effects by the combination of Benztropine and Dezocine.	Pain [MG30-MG3Z]	[9]
Codeine	DMJX6ZG	Moderate	Additive CNS depression effects by the combination of Benztropine and Codeine.	Pain [MG30-MG3Z]	[9]
Flavoxate	DMKV4NL	Moderate	Additive anticholinergic effects by the combination of Benztropine and Flavoxate.	Pain [MG30-MG3Z]	[6]
Nalbuphine	DMOSQGU	Moderate	Additive CNS depression effects by the combination of Benztropine and Nalbuphine.	Pain [MG30-MG3Z]	[9]
Buprenorphine	DMPRI8G	Moderate	Additive CNS depression effects by the combination of Benztropine and Buprenorphine.	Pain [MG30-MG3Z]	[9]
Hydrocodone	DMQ2JO5	Moderate	Additive CNS depression effects by the combination of Benztropine and Hydrocodone.	Pain [MG30-MG3Z]	[9]
Acetaminophen	DMUIE76	Minor	Altered absorption of Benztropine due to GI dynamics variation caused by Acetaminophen.	Pain [MG30-MG3Z]	[31]
Meperidine	DMX4GND	Moderate	Additive CNS depression effects by the combination of Benztropine and Meperidine.	Pain [MG30-MG3Z]	[9]
Oxycodone	DMXLKHV	Moderate	Additive CNS depression effects by the combination of Benztropine and Oxycodone.	Pain [MG30-MG3Z]	[9]
Methylscopolamine	DM5VWOB	Moderate	Additive anticholinergic effects by the combination of Benztropine and Methylscopolamine.	Peptic ulcer [DA61]	[6]
Levomepromazine	DMIKFEL	Moderate	Additive anticholinergic effects by the combination of Benztropine and Levomepromazine.	Psychotic disorder [6A20-6A25]	[6]
Fluphenazine	DMIT8LX	Moderate	Antagonize the effect of Benztropine when combined with Fluphenazine.	Psychotic disorder [6A20-6A25]	[11]
Triflupromazine	DMKFQJP	Moderate	Antagonize the effect of Benztropine when combined with Triflupromazine.	Psychotic disorder [6A20-6A25]	[11]
Cyproheptadine	DM92AH3	Moderate	Additive anticholinergic effects by the combination of Benztropine and Cyproheptadine.	Rheumatoid arthritis [FA20]	[6]
Quetiapine	DM1N62C	Moderate	Antagonize the effect of Benztropine when combined with Quetiapine.	Schizophrenia [6A20]	[11]
Mesoridazine	DM2ZGAN	Moderate	Antagonize the effect of Benztropine when combined with Mesoridazine.	Schizophrenia [6A20]	[11]
Thioridazine	DM35M8J	Moderate	Antagonize the effect of Benztropine when combined with Thioridazine.	Schizophrenia [6A20]	[11]
Aripiprazole	DM3NUMH	Moderate	Antagonize the effect of Benztropine when combined with Aripiprazole.	Schizophrenia [6A20]	[11]
Iloperidone	DM6AUFY	Moderate	Antagonize the effect of Benztropine when combined with Iloperidone.	Schizophrenia [6A20]	[11]
Paliperidone	DM7NPJS	Moderate	Antagonize the effect of Benztropine when combined with Paliperidone.	Schizophrenia [6A20]	[11]
Loxapine	DM8AI9U	Moderate	Antagonize the effect of Benztropine when combined with Loxapine.	Schizophrenia [6A20]	[11]
Haloperidol	DM96SE0	Moderate	Antagonize the effect of Benztropine when combined with Haloperidol.	Schizophrenia [6A20]	[11]
Perphenazine	DMA4MRX	Moderate	Antagonize the effect of Benztropine when combined with Perphenazine.	Schizophrenia [6A20]	[11]
Molindone	DMAH70G	Moderate	Antagonize the effect of Benztropine when combined with Molindone.	Schizophrenia [6A20]	[11]
Chlorpromazine	DMBGZI3	Moderate	Antagonize the effect of Benztropine when combined with Chlorpromazine.	Schizophrenia [6A20]	[11]
Thiothixene	DMDINC4	Moderate	Antagonize the effect of Benztropine when combined with Thiothixene.	Schizophrenia [6A20]	[11]
Clozapine	DMFC71L	Moderate	Antagonize the effect of Benztropine when combined with Clozapine.	Schizophrenia [6A20]	[11]
Trifluoperazine	DMKBYWI	Moderate	Antagonize the effect of Benztropine when combined with Trifluoperazine.	Schizophrenia [6A20]	[11]
Ziprasidone	DMM58JY	Moderate	Antagonize the effect of Benztropine when combined with Ziprasidone.	Schizophrenia [6A20]	[11]
Risperidone	DMN6DXL	Moderate	Antagonize the effect of Benztropine when combined with Risperidone.	Schizophrenia [6A20]	[11]
Olanzapine	DMPFN6Y	Moderate	Antagonize the effect of Benztropine when combined with Olanzapine.	Schizophrenia [6A20]	[11]
Asenapine	DMSQZE2	Moderate	Antagonize the effect of Benztropine when combined with Asenapine.	Schizophrenia [6A20]	[11]
Pimozide	DMW83TP	Moderate	Antagonize the effect of Benztropine when combined with Pimozide.	Schizophrenia [6A20]	[11]
Fentanyl	DM8WAHT	Moderate	Additive CNS depression effects by the combination of Benztropine and Fentanyl.	Sensation disturbance [MB40]	[9]
Sufentanil	DMU7YEL	Moderate	Additive CNS depression effects by the combination of Benztropine and Sufentanil.	Sensation disturbance [MB40]	[9]
Topiramate	DM82Z30	Major	Additive CNS depression effects by the combination of Benztropine and Topiramate.	Substance abuse [6C40]	[32]
Tizanidine	DMR2IQ4	Moderate	Additive CNS depression effects by the combination of Benztropine and Tizanidine.	Tonus and reflex abnormality [MB47]	[16]
Pramlintide	DM0EZ9Q	Moderate	Altered absorption of Benztropine due to GI dynamics variation caused by Pramlintide.	Type-1/2 diabete [5A10-5A11]	[33]
Atropine	DMEN6X7	Moderate	Additive anticholinergic effects by the combination of Benztropine and Atropine.	Unspecific substance harmful effect [NE6Z]	[6]
Nitrofurantoin	DM7PQIK	Minor	Altered absorption of Benztropine due to GI dynamics variation caused by Nitrofurantoin.	Urinary tract infection [GC08]	[34]
Chlorpheniramine	DM5URA2	Moderate	Additive anticholinergic effects by the combination of Benztropine and Chlorpheniramine.	Vasomotor/allergic rhinitis [CA08]	[6]
Triprolidine	DM7SWIA	Moderate	Additive anticholinergic effects by the combination of Benztropine and Triprolidine.	Vasomotor/allergic rhinitis [CA08]	[6]
Methdilazine	DMAUHQX	Moderate	Additive anticholinergic effects by the combination of Benztropine and Methdilazine.	Vasomotor/allergic rhinitis [CA08]	[6]
Clemastine	DMBZWQL	Moderate	Additive anticholinergic effects by the combination of Benztropine and Clemastine.	Vasomotor/allergic rhinitis [CA08]	[6]
Carbinoxamine	DMCT31R	Moderate	Additive anticholinergic effects by the combination of Benztropine and Carbinoxamine.	Vasomotor/allergic rhinitis [CA08]	[6]
Trimeprazine	DMEMV9D	Moderate	Additive anticholinergic effects by the combination of Benztropine and Trimeprazine.	Vasomotor/allergic rhinitis [CA08]	[6]
Brompheniramine	DMFOVSD	Moderate	Additive anticholinergic effects by the combination of Benztropine and Brompheniramine.	Vasomotor/allergic rhinitis [CA08]	[6]
Dexbrompheniramine	DMKVWGE	Moderate	Additive anticholinergic effects by the combination of Benztropine and Dexbrompheniramine.	Vasomotor/allergic rhinitis [CA08]	[6]
Cetirizine	DMOMP9U	Moderate	Additive CNS depression effects by the combination of Benztropine and Cetirizine.	Vasomotor/allergic rhinitis [CA08]	[35]
Acrivastine	DMTIGA0	Moderate	Additive anticholinergic effects by the combination of Benztropine and Acrivastine.	Vasomotor/allergic rhinitis [CA08]	[6]
Azatadine	DMZ80SB	Moderate	Additive anticholinergic effects by the combination of Benztropine and Azatadine.	Vasomotor/allergic rhinitis [CA08]	[6]
Disopyramide	DM5SYZP	Moderate	Additive anticholinergic effects by the combination of Benztropine and Disopyramide.	Ventricular tachyarrhythmia [BC71]	[6]

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Beta-D-lactose	E00099	6134	Diluent; Dry powder inhaler carrier; Lyophilization aid
Brushite	E00392	104805	Diluent
Calcium hydrogenphosphate	E00294	24441	Diluent
Carmellose sodium	E00625	Not Available	Disintegrant
Lactose monohydrate	E00393	104938	Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate	E00208	11177	lubricant
Povidone	E00667	Not Available	Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Silicon dioxide	E00670	Not Available	Anticaking agent; Opacifying agent; Viscosity-controlling agent
Talc	E00520	16211421	Anticaking agent; Diluent; Glidant; lubricant
Cellulose microcrystalline	E00698	Not Available	Adsorbent; Suspending agent; Diluent

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Benztropine Mesylate 2mg tablet	2mg	Tablet	Oral
Benztropine 2 mg tablet	2 mg	Oral Tablet	Oral
Benztropine 500 mcg tablet	500 mcg	Oral Tablet	Oral
Benztropine 0.5 mg tablet	0.5 mg	Oral Tablet	Oral
Benztropine 1 mg tablet	1 mg	Oral Tablet	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7601).
• [2] BDDCS predictions, self-correcting aspects of BDDCS assignments, BDDCS assignment corrections, and classification for more than 175 additional drugs
• [3] Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
• [4] Formulation and biopharmaceutical evaluation of transdermal patch containing benztropine. Int J Pharm. 2008 Jun 5;357(1-2):55-60.
• [5] Pharmacological characterization of a dopamine transporter ligand that functions as a cocaine antagonist. J Pharmacol Exp Ther. 2014 Jan;348(1):106-15.
• [6] Kulik AV, Wilbur R "Delirium and stereotypy from anticholinergic antiparkinson drugs." Prog Neuropsychopharmacol Biol Psychiatry 6 (1982): 75-82. [PMID: 7202232]
• [7] Algeri S, Cerletti C, Curcio M, et al. "Effect of anticholinergic drugs on gastro-intestinal absorption of L-dopa in rats and man." Eur J Pharmacol 35 (1976): 293-9. [PMID: 1248506]
• [8] Benjamin KW "Toxicity of ocular medications." Int Ophthalmol Clin 19 (1979): 199-255. [PMID: 376469]
• [9] Product Information. Artane (trihexyphenidyl). Lederle Laboratories, Wayne, NJ.
• [10] Katz IR, Sands LP, Bilker W, DiFilippo S, Boyce A, D'Angelo K "Identification of medications that cause cognitive impairment in older people: the case of oxybutynin chloride." J Am Geriatr Soc 46 (1998): 8-13. [PMID: 9434659]
• [11] Warnes H, Lehmann HE, Ban TA "Adynamic ileus during psychoactive medication: a report of three fatal and five severe cases." Can Med Assoc J 96 (1967): 1112-3. [PMID: 6021058]
• [12] Eronen M, Putkonen H, Hallikainen T, Vartiainen H "Lethal gastroenteritis associated with clozapine and loperamide." Am J Psychiatry 160 (2003): 2242-2243. [PMID: 14638602]
• [13] Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):.
• [14] Multum Information Services, Inc. Expert Review Panel.
• [15] Product Information. Anoro Ellipta (umeclidinium-vilanterol). GlaxoSmithKline, Research Triangle Park, NC.
• [16] Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
• [17] Product Information. GenESA (arbutamine). Gensia Inc, San Diego, CA.
• [18] Canadian Pharmacists Association.
• [19] Product Information. Nitrostat (nitroglycerin). Parke-Davis, Morris Plains, NJ.
• [20] Product Information. Zonegran (zonisamide) Elan Pharmaceuticals, S. San Francisco, CA.
• [21] Beermann B, Groschinsky-Grind M "Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline." Eur J Clin Pharmacol 13 (1978): 385-7. [PMID: 668798]
• [22] Product Information. Nizoral (ketoconazole). Janssen Pharmaceutica, Titusville, NJ.
• [23] Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
• [24] Brown DD, Schmid J, Long RA, Hull JH "A steady-state evaluation of the effects of propantheline bromide and cholestyramine on the bioavailability of digoxin when administered as tablets or capsules." J Clin Pharmacol 25 (1985): 360-4. [PMID: 4031112]
• [25] Briant RH, Dorrington RE, Ferry DG, Paxton JW "Bioavailability of metoprolol in young adults and the elderly, with additional studies on the effects of metoclopramide and probanthine." Eur J Clin Pharmacol 25 (1983): 353-6. [PMID: 6628522]
• [26] Leijonmarck CE, Raf L "Ulceration of the small intestine due to slow-release potassium chloride tablets." Acta Chir Scand 151 (1985): 273-8. [PMID: 4013604]
• [27] Postma JU, van Tilburg W "Visual hallucinations and delirium during treatment with amantadine (Symmetrel)." J Am Geriatr Soc 23 (1975): 212-5. [PMID: 123540]
• [28] EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
• [29] Product Information. Mestinon (pyridostigmine). ICN Pharmaceuticals Inc, Cost Mesa, CA.
• [30] Product Information. Motilium (domperidone). Janssen-Ortho Inc, Toronto, ON.
• [31] Clark JM, Seager SJ "Gastric emptying following premedication with glycopyrrolate or atropine." Br J Anaesth 55 (1983): 1195-9. [PMID: 6652009]
• [32] Mendelson J, Jones RT, Upton R, Jacob P 3rd "Methamphetamine and ethanol interactions in humans." Clin Pharmacol Ther 57 (1995): 559-68. [PMID: 7768079]
• [33] Product Information. Symlin (pramlintide). Amphastar Pharmaceuticals Inc, South El Monte, CA.
• [34] Jaffe JM "Effect of propantheline on nitrofurantoin absorption." J Pharm Sci 64 (1975): 1729-30. [PMID: 1185550]
• [35] Product Information. Zyrtec (cetirizine). Pfizer US Pharmaceuticals, New York, NY.