General Information of Drug (ID: DMBCANZ)

Drug Name
SB-237376 Drug Info
Synonyms
SB-237376; UNII-JED8M29NSU; JED8M29NSU; CHEMBL184461; SB-237376 free base; SCHEMBL6737235; XEAKAKKNLOUHDV-UHFFFAOYSA-N; BDBM50151854; n-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-4-nitrobenzamide; N-{3-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-propyl}-4-nitro-benzamide; Benzamide, N-(3-((2-(3,4-dimethoxyphenyl)ethyl)amino)propyl)-4-nitro-
Indication
Disease Entry ICD 11 Status REF
Arrhythmia BC9Z Terminated [1]
Cross-matching ID
PubChem CID
9845214
CAS Number
CAS 179258-59-4
TTD Drug ID
DMBCANZ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicardipine DMCDYW7 High blood pressure BA00 Approved [2]
Clevidipine butyrate DMW4M97 Hypertension BA00-BA04 Approved [3]
Nisoldipine DM7ISKJ Hypertension BA00-BA04 Approved [4]
Felodipine DMOSW35 Hypertension BA00-BA04 Approved [5]
Nimodipine DMQ0RKZ Cerebral vasospasm BA85.Z Approved [6]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [7]
Isradipine DMA5XGH Hypertension BA00-BA04 Approved [7]
DIPROTEVERINE HYDROCHLORIDE DMG8U6M Angina pectoris BA40 Phase 3 [8]
ATI-2042 DMWP59B Atrial fibrillation BC81.3 Phase 2 [9]
HBI-3000 DM74ZKN Heart arrhythmia BC65 Phase 2 [10]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [7]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [7]
Dronedarone DMA8FS5 Angina pectoris BA40 Approved [11]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [7]
Amifampridine DMK08L3 LambertEaton myasthenic syndrome 8C62 Approved [12]
Minoxidil DMA2Z4F Alopecia ED70 Approved [7]
Pinacidil DMRADYL High blood pressure BA00 Approved [7]
Dalfampridine DMM0PDO Multiple sclerosis 8A40 Approved [13]
Ibutilide DMKXY2R Atrial fibrillation BC81.3 Approved [7]
Diazoxide DML1538 Congenital hyperinsulinism 5A4Y Approved [7]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Calcium channel unspecific (CaC) TT5HONZ NOUNIPROTAC Modulator [1]
Potassium channel unspecific (KC) TT1VOHK NOUNIPROTAC Modulator [1]

References

1 Electrophysiologic effects of SB-237376: a new antiarrhythmic compound with dual potassium and calcium channel blocking action. J Cardiovasc Pharmacol. 2003 Mar;41(3):414-21.
2 Effect of intracoronary nicardipine on cardiac enzymes after elective percutaneous coronary intervention. Clin Cardiol. 2009 Jun;32(6):315-20.
3 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
4 RT-PCR and pharmacological analysis of L-and T-type calcium channels in rat carotid body. Adv Exp Med Biol. 2009;648:105-12.
5 Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: block by antihypertensives, antiarrhythmics, and their analogs. J Pharmacol Exp Ther. 2009 Feb;328(2):621-7.
6 Influence of bupropion and calcium channel antagonists on the nicotine-induced memory-related response of mice in the elevated plus maze. Pharmacol Rep. 2009 Mar-Apr;61(2):236-44.
7 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
8 Prenatal toxicity studies in rats and rabbits with the calcium channel blocker diproteverine. Reprod Toxicol. 1996 Jan-Feb;10(1):43-9.
9 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
10 Electrophysiological properties of HBI-3000: a new antiarrhythmic agent with multiple-channel blocking properties in human ventricular myocytes. J Cardiovasc Pharmacol. 2011 Jan;57(1):79-85.
11 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
12 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
13 Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.