Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBJERO)

Drug Name

BCX-140 Drug Info

Synonyms

4-(Acetylamino)-3-guanidinobenzoic acid; BANA-113; UNII-V02KF5948M; BANA 113; CHEMBL55440; 170447-93-5; V02KF5948M; Benzoic acid, 4-(acetylamino)-3-((aminoiminomethyl)amino)-; 4-acetamido-3-guanidino-benzoic acid; Benzoic acid, 4-(acetylamino)-3-[(aminoiminomethyl)amino]-; 1inf; AC1L9JI9; 4-acetamido-3-(diaminomethylideneamino)benzoic acid; SCHEMBL141675; BDBM4707; UDQJOWCVSMIZJP-UHFFFAOYSA-N; 4-Acetylamino-3-guanidino-benzoic acid; 3-carbamimidamido-4-acetamidobenzoic acid; 3-(2,2-diaminoimino)-4-methylcarboxamidobenzoate; BANA-113; BANA-153; BANA-205; BANA-206; Neuraminidase inhibitors, BioCryst; 4-(Acetylamino)-3-Guanidinobenzoic Acid

Indication

Disease Entry	ICD 11	Status	REF
Influenza virus infection	1E30-1E32	Terminated	[1]

Cross-matching ID

PubChem CID: 446323
CAS Number: CAS 170447-93-5
TTD Drug ID: DMBJERO

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Influenza Neuraminidase (Influ NA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oseltamivir	DMGO72P	Influenza virus infection	1E30-1E32	Approved	[5]
Zanamivir	DMFMBZ4	Influenza virus infection	1E30-1E32	Approved	[5]
Peramivir	DMNXY5K	Influenza virus infection	1E30-1E32	Approved	[6]
UX-001	DMD2O0L	Hereditary inclusion body myositis	4A41.2	Phase 3	[7]
CS-8958	DM4CSDH	Influenza virus infection	1E30-1E32	Phase 3	[6]
DAS-181	DM0Y8JP	Influenza virus infection	1E30-1E32	Phase 2	[8]
GS-3435	DMV7JC6	Influenza virus infection	1E30-1E32	Terminated	[9]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[7]
Fucose	DMAHMSV	N. A.	N. A.	Investigative	[7]
Apigenin	DMI3491	Discovery agent	N.A.	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Influenza Neuraminidase (Influ NA)	TT50QJ3	NRAM_I33A0	Inhibitor	[2] , [3] , [4]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006335)
2	CN patent application no. 104447481, Benzoic acid thiourea anti-influenza virus compounds as well as preparation method and use thereof.
3	Neuraminidase inhibitors: zanamivir and oseltamivir. Ann Pharmacother. 2001 Jan;35(1):57-70.
4	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
5	Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res. 2008 Apr;78(1):91-102.
6	Developing new antiviral agents for influenza treatment: what does the future hold Clin Infect Dis. 2009 Jan 1;48 Suppl 1:S3-13.
7	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
8	Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein. PLoS One. 2009 Nov 6;4(11):e7838.
9	US patent application no. 2010,0081,713, Compositions and methods for treating viral infections.
10	Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. Bioorg Med Chem. 2009 Oct 1;17(19):6816-23.