Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMBNWM1)

Drug Name

Cilofungin Drug Info

Synonyms

Cilofungina; Cilofunginum; L-646991; LY-121019; Cilofungin (USAN/INN); L-649,991; 1-[(4R,5R)-4,5-Dihydroxy-N2-[4-(octyloxy)benzoyl]-L-ornithine]echinocandin B; 5.1:6-anhydro{(4R,5R)-4,5-dihydroxy-N(2)-[4-(octyloxy)benzoyl]-L-ornithyl-L-threonyl-(4R)-4-hydroxy-L-prolyl-(4S)-4-hydroxy-4-(4-hydroxyphenyl)-L-threonyl-L-threonyl-(3S,4S)-3-hydroxy-4-methyl-L-proline}

Indication

Disease Entry	ICD 11	Status	REF
Candidiasis	1F23	Terminated	[1]

Cross-matching ID

PubChem CID: 6918120
ChEBI ID: CHEBI:315019
CAS Number: CAS 79404-91-4
TTD Drug ID: DMBNWM1

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Fungal Papulacandin B resistance protein 1 (Fung FKS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-692289	DMAB1RW	Discovery agent	N.A.	Investigative	[3]
Pyridobenzimidazole	DM3PAS4	Fungal infection	1F29-1F2F	Investigative	[4]
ACULEACIN A	DMR2MUG	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fungal Papulacandin B resistance protein 1 (Fung FKS1)	TTZMS1L	FKS1_YEAST	Inhibitor	[2]

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References

1	Fungi: Biology and Applications, Kevin Kavanagh. Page(211).
2	Cryptococcus neoformans resistance to echinocandins: (1,3)beta-glucan synthase activity is sensitive to echinocandins. Antimicrob Agents Chemother. 2005 Jul;49(7):2851-6.
3	Antifungal lipopeptides: Structure-activity relationships of 3-hydroxyglutamine-modified pneumocandin B0 derivatives, Bioorg. Med. Chem. Lett. 5(20):2357-2362 (1995).
4	Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009). Rev Iberoam Micol. 2009 Mar 31;26(1):15-22.
5	Synthesis, anti-fungal and 1,3--D-glucan synthase inhibitory activities of caffeic and quinic acid derivatives. Bioorg Med Chem. 2010 Oct 1;18(19):7009-14.