General Information of Drug (ID: DMBQC3L)

Drug Name
Verubulin Drug Info
Synonyms
Azixa; Verubulin hydrochloride; EP-128495; MPC-6827; Apoptosis inducer (cancer), Myriad; Caspase inducer (cancer), Myriad; Cell cycle arrest inducer (cancer), Myriad; Tubulin inhibitor (cancer), Myriad
Indication
Disease Entry ICD 11 Status REF
Brain metastases 2D50 Phase 2 [1]
Glioblastoma multiforme 2A00.0 Phase 2 [2]
Recurrent glioblastoma 2A00.00 Phase 2 [1]
Solid tumour/cancer 2A00-2F9Z Phase 2 [3]
Cross-matching ID
PubChem CID
11414799
CAS Number
CAS 827031-83-4
TTD Drug ID
DMBQC3L

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug(s) Targeting Tubulin beta (TUBB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vincristine DMINOX3 Acute lymphoblastic leukaemia 2A85 Approved [5]
Albendazole DMYZ57N Echinococcus granulosus infectious disease Approved [6]
Vindesine DMVR628 Acute lymphoblastic leukaemia 2A85 Approved [7]
Taxol DMUOT9V Breast cancer 2C60-2C65 Approved [8]
Mebendazole DMO14SG Ascariasis 1F62 Approved [6]
Plinabulin DMD7L48 Non-small-cell lung cancer 2C25.Y Phase 3 [9]
Batabulin DMHWE5R Solid tumour/cancer 2A00-2F9Z Phase 2/3 [10]
ABT-751 DMNG35S Solid tumour/cancer 2A00-2F9Z Phase 2 [11]
DOLASTATIN-10 DMDUV1S Solid tumour/cancer 2A00-2F9Z Phase 2 [12]
BNC-105 DMJC8DR Mesothelioma 2C51.2 Phase 2 [13]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tubulin beta (TUBB) TTYFKSZ NOUNIPROTAC Modulator [4]

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 ClinicalTrials.gov (NCT01285414) Verubulin, Radiation Therapy, and Temozolomide to Treat Patients With Newly Diagnosed Glioblastoma Multiforme. U.S. National Institutes of Health.
4 Effects of the tumor-vasculature-disrupting agent verubulin and two heteroaryl analogues on cancer cells, endothelial cells, and blood vessels.ChemMedChem.2014 Apr;9(4):847-54.
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6 Flubendazole interferes with a wide spectrum of cell homeostatic mechanisms in Echinococcus granulosus protoscoleces. Parasitol Int. 2009 Sep;58(3):270-7.
7 Antiproliferating activity of the mitotic inhibitor pironetin against vindesine- and paclitaxel-resistant human small cell lung cancer H69 cells. Anticancer Res. 2007 Mar-Apr;27(2):729-36.
8 Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77. Cancer Res. 2009 Sep 1;69(17):6906-14.
9 NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent. Anticancer Drugs. 2006 Jan;17(1):25-31.
10 Hydrophilic, pro-drug analogues of T138067 are efficacious in controlling tumor growth in vivo and show a decreased ability to cross the blood brain barrier. J Med Chem. 2001 Oct 25;44(22):3599-605.
11 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
12 Total synthesis and biological evaluation of ustiloxin natural products and two analogs. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4804-7.
13 The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer.Cancer Biol Ther.2014;15(11):1552-60.