Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC50VB)

• Drug Name: Orforglipron Drug Info
• Synonyms: Orforglipron; LY3502970; 2212020-52-3; CHEMBL4446782; LY-3502970; 3-[(1S,2S)-1-(5-[(4S)-2,2-dimethyloxan-4-yl]-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl)-2-methylcyclopropyl]-1,2,4-oxadiazol-5(4H)-one; 3-[(1S,2S)-1-[5-[(4S)-2,2-dimethyloxan-4-yl]-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carbonyl]indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one; V6G; orforglipron [INN]; ORFORGLIPRON [USAN]; OWL833; SCHEMBL21175277; GTPL12175; 7ZW40D021M; EX-A7751; BDBM50514045; AKOS040733262; GLP-1 receptor agonist 1;Orforglipron; MS-31635; HY-112185; CS-0043632; 1,2,4-Oxadiazol-5(2H)-one, 3-[(1S,2S)-1-[2-[[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2,3-dihydro-2-oxo-1H-imidazol-1-yl]-2,4,6,7-tetrahydro-4-methyl-5H-pyrazolo[4,3-c]pyridin-5-yl]carbonyl]-5-[(4S)-tetrahydro-2,2-dimethyl-2H-pyran-4-yl]-1H-indol-1-yl]-2-methylcyclopropyl]-; 3-[(1S,2S)-1-({2-(4-fluoro-3,5-dimethylphenyl)-3-({3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}carbonyl)-5-[(4S)-2,2-dimethyloxan-4-yl]-1H-indol-1-yl}-2-methylcyclopropyl]-5-oxo-1,2,4-oxadiazol-4(5H)-ide

Indication

Disease Entry	ICD 11	Status	REF
Obesity	5B81	Phase 3	[1]
Type 2 diabetes	5A11	Phase 2	[2]

• Cross-matching ID:
  PubChem CID: 137319706
  TTD Drug ID: DMC50VB

Molecule-Related Drug Atlas

Drug(s) Targeting Glucagon-like peptide 1 receptor (GLP1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Semaglutide	DMAGFOD	Type-2 diabetes	5A11	Approved	[4]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[5]
Exenatide	DMYHBKN	Inflammation	1A00-CA43.1	Approved	[6]
Dulaglutide	DMYXBV3	Type-2 diabetes	5A11	Approved	[7]
Lixisenatide	DM0QJDC	Type-2 diabetes	5A11	Approved	[8]
Pramlintide	DM0EZ9Q	Type-1/2 diabetes	5A10-5A11	Approved	[5]
Albiglutide	DM1JEGF	Type-2 diabetes	5A11	Approved	[8]
Tirzepatide	DMQNMAT	Type 2 diabetes	5A11	Approved	[9]
Efpeglenatide	DMKA2PI	Type-2 diabetes	5A11	Phase 3	[10]
GLP-1	DMR6YH3	Diabetic complication	5A2Y	Phase 3	[4]
Semaglutide	DMAGFOD	Type-2 diabetes	5A11	Approved	[4]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[5]
Exenatide	DMYHBKN	Inflammation	1A00-CA43.1	Approved	[6]
Dulaglutide	DMYXBV3	Type-2 diabetes	5A11	Approved	[7]
Lixisenatide	DM0QJDC	Type-2 diabetes	5A11	Approved	[8]
Pramlintide	DM0EZ9Q	Type-1/2 diabetes	5A10-5A11	Approved	[5]
Albiglutide	DM1JEGF	Type-2 diabetes	5A11	Approved	[8]
Tirzepatide	DMQNMAT	Type 2 diabetes	5A11	Approved	[9]
Efpeglenatide	DMKA2PI	Type-2 diabetes	5A11	Phase 3	[10]
GLP-1	DMR6YH3	Diabetic complication	5A2Y	Phase 3	[4]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucagon-like peptide 1 receptor (GLP1R)	TTVIMDE	GLP1R_HUMAN	Agonist	[3]

References

• [1] ClinicalTrials.gov (NCT05869903) A Phase 3, Randomized, Double-Blind Study to Investigate the Efficacy and Safety of Once-Daily Oral LY3502970 Compared With Placebo in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-1). U.S.National Institutes of Health.
• [2] ClinicalTrials.gov (NCT05048719) A Phase 2 Study of Once-Daily LY3502970 Compared With Placebo and Once-Weekly Dulaglutide in Participants With Type 2 Diabetes Mellitus. U.S.National Institutes of Health.
• [3] Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist. Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29959-29967.
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 249).
• [5] Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
• [6] Improved glycemic control and reduction of cardiometabolic risk factors in subjects with type 2 diabetes and metabolic syndrome treated with exenatide in a clinical practice setting. Diabetes TechnolTher. 2009 Jun;11(6):353-9.
• [7] 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
• [8] GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus.Nat Rev Endocrinol.2012 Dec;8(12):728-42.
• [9] Dual GIP and GLP-1 Receptor Agonist Tirzepatide Improves Beta-cell Function and Insulin Sensitivity in Type 2 Diabetes. J Clin Endocrinol Metab. 2021 Jan 23;106(2):388-396.
• [10] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)