Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC64EI)

Drug Name

Beta-Alanine Drug Info

Synonyms

beta-alanine; 107-95-9; 3-Aminopropanoic acid; 3-Aminopropionic acid; Beta Alanine; Abufene; H-beta-Ala-OH; beta-Aminopropionic acid; 2-Carboxyethylamine; .beta.-Alanine; Propanoic acid, 3-amino-; Alanine, beta-; 3-Aminopropionsaeure; beta-Ala; beta-Aminopropionsaeure; 3-Aminopropanoate; omega-Aminopropionic acid; B-ALANINE; FEMA No. 3252; 3-amino-propionic acid; beta-Alaine; AI3-18470; .beta.-Aminopropionic acid; NSC 7603; UNII-11P2JDE17B; beta-Alanine, 99%; EINECS 203-536-5; MFCD00008200; 11P2JDE17B; CHEMBL297569; CHEBI:16958; NSC7603

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 239
ChEBI ID: CHEBI:16958
CAS Number: CAS 107-95-9
TTD Drug ID: DMC64EI
VARIDT Drug ID: DR00306

Molecule-Related Drug Atlas

Molecule Type:

DTT

DTP

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting GABA transporter-3 (SLC6A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[4]
NIPECOTIC ACID	DMPV450	Discovery agent	N.A.	Investigative	[4]
2,4-Diamino-butyric acid(GABA)	DMAOGBP	Discovery agent	N.A.	Investigative	[5]
4-Hydroxy-piperidine-3-carboxylic acid	DM9VQ0T	Discovery agent	N.A.	Investigative	[6]
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Drug(s) Transported By Sodium- and chloride-dependent taurine transporter (SLC6A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
taurine	DMVW7N3	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA transporter-3 (SLC6A11)	TT8RXO5	S6A11_HUMAN	Blocker	[2]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Sodium- and chloride-dependent taurine transporter (SLC6A6)	DTHWCVA	SC6A6_HUMAN	Substrate	[3]
Sodium- and chloride-dependent GABA transporter 3 (SLC6A11)	DTXBIQG	S6A11_HUMAN	Substrate	[3]
Sodium- and chloride-dependent GABA transporter 2 (SLC6A13)	DTX8KP0	S6A13_HUMAN	Substrate	[3]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2365).
2	Stable expression of a neuronal gamma-aminobutyric acid transporter, GAT-3, in mammalian cells demonstrates unique pharmacological properties and ion dependence. Mol Pharmacol. 1994 Sep;46(3):550-7.
3	Astrocytic -aminobutyric acid (GABA) transporters mediate guanidinoacetate transport in rat brain. 2018 Feb;113:1-7.
4	Epimeric cis-decahydroquinoline-5-carboxylic acids: effects on gamma-aminobutyric acid uptake and receptor binding in vitro. J Med Chem. 1981 Jul;24(7):788-94.
5	Glycine antagonists. Synthesis, structure, and biological effects of some bicyclic 5-isoxazolol zwitterions. J Med Chem. 1986 Feb;29(2):224-9.
6	Hydroxy- and amino-substituted piperidinecarboxylic acids as gamma-aminobutyric acid agonists and uptake inhibitors. J Med Chem. 1982 Oct;25(10):1157-62.