Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCMIJ1)

Drug Name
NT0202 Drug Info
Synonyms Amphetamine polistirex
Indication
Disease Entry ICD 11 Status REF
Attention deficit hyperactivity disorder 6A05.Z Phase 3 [1]
Cross-matching ID
TTD Drug ID
DMCMIJ1

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Trace amine-associated receptor-1 (TAAR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amphetamine DMSZQAK Attention deficit hyperactivity disorder 6A05.Z Approved [1]
Lisdexamfetamine DM6W8V5 Attention deficit hyperactivity disorder 6A05.Z Approved [2]
Dextroamphetamine DMMIHVP Attention deficit hyperactivity disorder 6A05.Z Approved [1]
Hydroxyamphetamine Hydrobromide DMQSGM0 Horner syndrome 8D8A.1 Approved [3]
SEP-363856 DMG2QP4 Schizophrenia 6A20 Phase 3 [4]
SPD-465 DM7NV1I Attention deficit hyperactivity disorder 6A05.Z Phase 3 [1]
RG-7351 DMFGR98 Major depressive disorder 6A70.3 Phase 1 [5]
tyramine DM4UXT1 Discovery agent N.A. Investigative [6]
EPPTB DMK3VID Discovery agent N.A. Investigative [7]
R(-)amphetamine DM72ES1 Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Trace amine-associated receptor-1 (TAAR1) TTIU98M TAAR1_HUMAN Agonist [1]

References

1 Methamphetamine and HIV-1-induced neurotoxicity: role of trace amine associated receptor 1 cAMP signaling in astrocytes. Neuropharmacology. 2014 Oct;85:499-507.
2 2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
3 Diagnostic pharmacology of the pupil.Clin Neuropharmacol.1985;8(1):27-37.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Clinical pipeline report, company report or official report of Roche.
6 Differential modulation of Beta-adrenergic receptor signaling by trace amine-associated receptor 1 agonists. PLoS One. 2011;6(10):e27073.
7 The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20081-6.
8 The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia. Genes Brain Behav. 2007 Oct;6(7):628-39.