General Information of Drug (ID: DME94QF)

Drug Name
Furnidipine Drug Info
Synonyms Furaldipine; CRE-319
Indication
Disease Entry ICD 11 Status REF
Nerve injury ND56.4 Discontinued in Phase 3 [1]
Cross-matching ID
PubChem CID
65988
CAS Number
CAS 138661-03-7
TTD Drug ID
DME94QF

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nifedipine DMSVOZT Angina pectoris BA40 Approved [3]
Clevidipine butyrate DMW4M97 Hypertension BA00-BA04 Approved [4]
Epalrestat DM5OGK0 Diabetic neuropathy 8C0Z Approved [5]
Otilonium bromide DM05968 Gastric motility disorder DA21 Approved [6]
Levamlodipine DM92S6N Hypertension BA00-BA04 Phase 4 [7]
Cilnidipine DM1975O High blood pressure BA00 Phase 3 [8]
Pinaverium bromide DM7OSHC Irritable bowel syndrome DD91.0 Phase 3 [6]
MEM-1003 DMYZU6G Bipolar disorder 6A60 Phase 2a [9]
Gallopamil DMXBR27 Asthma CA23 Phase 2 [10]
BAY-Y-5959 DMLO18H Cardiovascular disease BA00-BE2Z Phase 2 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated L-type calcium channel (L-CaC) TTXHYV6 NOUNIPROTAC Modulator [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002558)
2 Q-type Ca2+ channels are located closer to secretory sites than L-type channels: functional evidence in chromaffin cells. Pflugers Arch. 1998 Mar;435(4):472-8.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
5 Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Curr Top Med Chem. 2009;9(4):377-95.
6 Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313.
7 Effects of (S)-amlodipine and (R)-amlodipine on L-type calcium channel current of rat ventricular myocytes and cytosolic calcium of aortic smooth muscle cells. Pharmazie. 2008 Jun;63(6):470-4.
8 N- and L-type calcium channel antagonist improves glomerular dynamics, reverses severe nephrosclerosis, and inhibits apoptosis and proliferation in an l-NAME/SHR model. J Hypertens. 2002 May;20(5):993-1000.
9 Efficacy of MEM 1003, a novel calcium channel blocker, in delay and trace eyeblink conditioning in older rabbits. Neurobiol Aging. 2007 May;28(5):766-73.
10 Role of apoptosis in the kidney after reperfusion. Orv Hetil. 2008 Feb 17;149(7):305-15.
11 Hemodynamic effects of a calcium channel promoter, BAY y 5959, are preserved after chronic administration in ischemic heart failure in conscious dogs. J Pharmacol Exp Ther. 1998 Aug;286(2):760-6.