Details of the Drug

General Information of Drug (ID: DMSVOZT)

Drug Name
Nifedipine
Synonyms
Adalat; Adalate; Adapine; Adapress; Afeditab; Alat; Aldipin; Alfadal; Alonix; Angipec; Anifed; Anpine; Aprical; Bonacid; Calcibloc; Calcigard; Calcilat; Camont; Cardifen; Cardilat; Cardionorm; Chronadalate; Citilat; Coracten; Coral; Cordafen; Cordaflex; Cordalat; Cordicant; Cordilan; Cordipin; Cordipine; Corinfar; Corotrend; Corynphar; Depin; Dignokonstant; Dilafed; Dipinkor; Duranifin; Ecodipi; Ecodipin; Emaberin; Fedcor; Fenamon; Fenigidin; Fenihidin; Fenihidine; Glopir; Hadipin; Hexadilat; Infedipin; Introcar; Kordafen; Korinfar; Macorel; Megalat; Myogard; Nedipin; Nicardia; Nifangin; Nifar; Nifdemin; Nifebene; Nifecard; Nifecor; Nifedepat; Nifediac; Nifedical; Nifedicor; Nifedin; Nifedine; Nifedipino; Nifedipinum; Nifedipres; Nifelan; Nifelat; Nifelate; Nificard; Nifidine; Nifipen; Niphedipine; Orix; Oxcord; Pidilat; Procardia; Sepamit; Tibricol; Vascard; Zenusin; AWD Pharma Brand of Nifedipine; Adalat CC; Adalat CR; Adalat Crono; Adalat FT; Adalat GITS; Adalat LA; Adalat LP; Adalat Oros; Adalat PA; Adalat Retard; Adalat XL; Adalate LP; Adcock Ingram Brand of Nifedipine; Adipine XL; Afeditab CR; Alonix S; Aprical long; Bayer Brand of Nifedipine; Chronadalate LP; Coracten XL; Ecodipin E; Fedcor Retard; Fenamon SR; Fortipine LA; KRKA Brand of Nifedipine; Nifedical XL; Nifedipine Bayer Brand; Nifedipine GTIS; Nifedipine KRKA Brand; Nifedipine Monohydrochloride; Nifedipine Orion Brand; Nifedipine Pfizer Brand; Nifedipine Retard; Nifedirex LP; Nifelat Q; Nifensar XL; Orion Brand of Nifedipine; Pfizer Brand of Nifedipine; Procardia XL; Slofedipine XL; Tensipine MR; Adalat 10; Adalat 20; Adalat 5; Adalat GITS 30; Bay1040; N 7634; N1fedilat; Adalat (TN); Afeditab CR (TN); Alpha-Nifedipine Retard;Apo-Nifed; Bay-1040; KB-1712P; Monohydrochloride, Nifedipine; Nifedical (TN); Nifedipine-GTIS; Nifedipino [INN-Spanish]; Nifedipinum [INN-Latin]; Procardia (TN); Bay-a-1040; Nifedipine (JP15/USP/INN); Nifedipine [USAN:BAN:INN:JAN]
Indication
Disease Entry ICD 11 Status REF
Angina pectoris BA40 Approved [1]
Premature labour JB00 Approved [2]
Therapeutic Class
Analgesics
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 346.3
Logarithm of the Partition Coefficient (xlogp) 2.2
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 7
ADMET Property
Absorption AUC
The area under the plot of plasma concentration (AUC) of drug is 25 mcgh/L [3]
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 10 mcg/L [3]
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 2: low solubility and high permeability [4]
Clearance
The total body clearance of drug is 450-700 mL/min [5]
Elimination
Nifedipine is 60-80% recovered in the urine as inactive water soluble metabolites, and the rest is eliminated in the feces as metabolites [6]
Half-life
The concentration or amount of drug in body reduced by one-half in 2 hours [5]
Metabolism
The drug is metabolized via the CYP3A4 [7]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 3.7123 micromolar/kg/day [8]
Unbound Fraction
The unbound fraction of drug in plasma is 0.044% [9]
Vd
The volume of distribution (Vd) of drug is 0.62-0.77 L/kg [5]
Water Solubility
The ability of drug to dissolve in water is measured as 0.006 mg/mL [4]
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Adverse drug reaction Not Available AHCYL1 OTX8L3M5 [10]
Gingival hyperplasia Not Available AR DHTR NR3C4 OTUBKAZZ [10]
Chemical Identifiers
Formula
C17H18N2O6
IUPAC Name
dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Canonical SMILES
CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
InChI
InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
InChIKey
HYIMSNHJOBLJNT-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
4485
ChEBI ID
CHEBI:7565
CAS Number
21829-25-4
DrugBank ID
DB01115
TTD ID
D04OSE
VARIDT ID
DR00396
INTEDE ID
DR1152
ACDINA ID
D00467
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Voltage-gated L-type calcium channel (L-CaC) TTXHYV6 NOUNIPROTAC Modulator [11]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [12]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4)
Main DME 		DE4LYSA CP3A4_HUMAN Substrate [13]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [14]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [15]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [16]
Cytochrome P450 102A1 (cyp102) DE4OGUF CPXB_BACMB Substrate [17], [18]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Drug Response [10]
Apolipoprotein A-I (APOA1) OT5THARI APOA1_HUMAN Gene/Protein Processing [19]
Apolipoprotein A-II (APOA2) OTQ3HGTC APOA2_HUMAN Gene/Protein Processing [19]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [20]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Gene/Protein Processing [21]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [22]
Bile acid receptor (NR1H4) OTWZLPTB NR1H4_HUMAN Gene/Protein Processing [23]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [24]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [25]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [26]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Nifedipine (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Pioglitazone DMKJ485 Minor Altered absorption of Nifedipine caused by Pioglitazone. Acute diabete complication [5A2Y] [27]
Ivosidenib DM8S6T7 Moderate Increased metabolism of Nifedipine caused by Ivosidenib mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [28]
Midostaurin DMI6E0R Moderate Decreased metabolism of Nifedipine caused by Midostaurin mediated inhibition of CYP450 enzyme. Acute myeloid leukaemia [2A60] [29]
Idarubicin DMM0XGL Moderate Decreased clearance of Nifedipine due to the transporter inhibition by Idarubicin. Acute myeloid leukaemia [2A60] [30]
Arn-509 DMT81LZ Major Increased metabolism of Nifedipine caused by Arn-509 mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [31]
Gilteritinib DMTI0ZO Moderate Decreased clearance of Nifedipine due to the transporter inhibition by Gilteritinib. Acute myeloid leukaemia [2A60] [32]
Emapalumab DMZG5WL Moderate Altered metabolism of Nifedipine due to Emapalumab alters the formation of CYP450 enzymes. Adaptive immunity immunodeficiency [4A01] [32]
Siltuximab DMGEATB Moderate Altered metabolism of Nifedipine due to Siltuximab alters the formation of CYP450 enzymes. Anemia [3A00-3A9Z] [32]
Cilostazol DMZMSCT Moderate Decreased metabolism of Nifedipine caused by Cilostazol mediated inhibition of CYP450 enzyme. Arterial occlusive disease [BD40] [33]
Posaconazole DMUL5EW Moderate Decreased metabolism of Nifedipine caused by Posaconazole mediated inhibition of CYP450 enzyme. Aspergillosis [1F20] [34]
Budesonide DMJIBAW Moderate Decreased metabolism of Nifedipine caused by Budesonide mediated inhibition of CYP450 enzyme. Asthma [CA23] [35]
Dalfopristin DM4LTKV Moderate Decreased metabolism of Nifedipine caused by Dalfopristin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [36]
Clarithromycin DM4M1SG Moderate Decreased metabolism of Nifedipine caused by Clarithromycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [37]
Troleandomycin DMUZNIG Moderate Decreased metabolism of Nifedipine caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [37]
Cariprazine DMJYDVK Moderate Decreased metabolism of Nifedipine caused by Cariprazine mediated inhibition of CYP450 enzyme. Bipolar disorder [6A60] [38]
Erdafitinib DMI782S Moderate Increased metabolism of Nifedipine caused by Erdafitinib mediated induction of CYP450 enzyme. Bladder cancer [2C94] [39]
Pexidartinib DMS2J0Z Major Decreased metabolism of Nifedipine caused by Pexidartinib mediated inhibition of CYP450 enzyme. Bone/articular cartilage neoplasm [2F7B] [40]
Talazoparib DM1KS78 Moderate Decreased clearance of Nifedipine due to the transporter inhibition by Talazoparib. Breast cancer [2C60-2C6Y] [41]
Ixabepilone DM2OZ3G Moderate Decreased metabolism of Nifedipine caused by Ixabepilone mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [42]
Lapatinib DM3BH1Y Moderate Decreased metabolism of Nifedipine caused by Lapatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [43]
Tucatinib DMBESUA Moderate Decreased metabolism of Nifedipine caused by Tucatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [44]
Palbociclib DMD7L94 Moderate Decreased metabolism of Nifedipine caused by Palbociclib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [32]
Cabazitaxel DMPAZHC Moderate Decreased metabolism of Nifedipine caused by Cabazitaxel mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [45]
Bosutinib DMTI8YE Moderate Decreased clearance of Nifedipine due to the transporter inhibition by Bosutinib. Breast cancer [2C60-2C6Y] [32]
Macitentan DMP79A1 Moderate Decreased metabolism of Nifedipine caused by Macitentan mediated inhibition of CYP450 enzyme. Cardiovascular disease [BA00-BE2Z] [46]
PF-04449913 DMSB068 Moderate Decreased metabolism of Nifedipine caused by PF-04449913 mediated inhibition of CYP450 enzyme. Chronic myelomonocytic leukaemia [2A40] [47]
Indacaterol DMQJHR7 Minor Decreased clearance of Nifedipine due to the transporter inhibition by Indacaterol. Chronic obstructive pulmonary disease [CA22] [48]
Fidaxomicin DMFP6MV Minor Decreased clearance of Nifedipine due to the transporter inhibition by Fidaxomicin. Clostridium difficile enterocolitis [1A04] [49]
Intedanib DMSTA36 Moderate Decreased metabolism of Nifedipine caused by Intedanib mediated inhibition of CYP450 enzyme. Colorectal cancer [2B91] [50]
Ulipristal DMBNI20 Minor Decreased metabolism of Nifedipine caused by Ulipristal mediated inhibition of CYP450 enzyme. Contraceptive management [QA21] [32]
Osilodrostat DMIJC9X Moderate Decreased metabolism of Nifedipine caused by Osilodrostat mediated inhibition of CYP450 enzyme. Cushing syndrome [5A70] [32]
Lumacaftor DMCLWDJ Major Increased metabolism of Nifedipine caused by Lumacaftor mediated induction of CYP450 enzyme. Cystic fibrosis [CA25] [31]
Ivacaftor DMZC1HS Moderate Decreased metabolism of Nifedipine caused by Ivacaftor mediated inhibition of CYP450 enzyme. Cystic fibrosis [CA25] [51]
MK-8228 DMOB58Q Moderate Decreased metabolism of Nifedipine caused by MK-8228 mediated inhibition of CYP450 enzyme. Cytomegaloviral disease [1D82] [52]
Rivaroxaban DMQMBZ1 Moderate Decreased clearance of Nifedipine due to the transporter inhibition by Rivaroxaban. Deep vein thrombosis [BD71] [53]
Nefazodone DM4ZS8M Moderate Decreased metabolism of Nifedipine caused by Nefazodone mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [54]
Isocarboxazid DMAF1NB Moderate Additive hypotensive effects by the combination of Nifedipine and Isocarboxazid. Depression [6A70-6A7Z] [55]
Escitalopram DMFK9HG Minor Decreased metabolism of Nifedipine caused by Escitalopram mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [56]
OPC-34712 DMHG57U Moderate Additive hypotensive effects by the combination of Nifedipine and OPC-34712. Depression [6A70-6A7Z] [57]
Polatuzumab vedotin DMF6Y0L Moderate Decreased metabolism of Nifedipine caused by Polatuzumab vedotin mediated inhibition of CYP450 enzyme. Diffuse large B-cell lymphoma [2A81] [58]
Cenobamate DM8KLU9 Moderate Increased metabolism of Nifedipine caused by Cenobamate mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [59]
Stiripentol DMMSDOY Moderate Decreased metabolism of Nifedipine caused by Stiripentol mediated inhibition of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [32]
Fosphenytoin DMOX3LB Major Increased metabolism of Nifedipine caused by Fosphenytoin mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [31]
Rufinamide DMWE60C Moderate Increased metabolism of Nifedipine caused by Rufinamide mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [32]
Phenobarbital DMXZOCG Major Increased metabolism of Nifedipine caused by Phenobarbital mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [31]
Nadolol DMW6GVL Moderate Increased risk of cardiac depression by the combination of Nifedipine and Nadolol. Essential hypertension [BA00] [60]
Tazemetostat DMWP1BH Moderate Increased metabolism of Nifedipine caused by Tazemetostat mediated induction of CYP450 enzyme. Follicular lymphoma [2A80] [61]
Solifenacin DMG592Q Moderate Decreased metabolism of Nifedipine caused by Solifenacin mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [62]
Mirabegron DMS1GYT Minor Decreased metabolism of Nifedipine caused by Mirabegron mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [63]
Ripretinib DM958QB Moderate Decreased metabolism of Nifedipine caused by Ripretinib mediated inhibition of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [49]
Avapritinib DMK2GZX Moderate Decreased metabolism of Nifedipine caused by Avapritinib mediated inhibition of CYP450 enzyme. Gastrointestinal stromal tumour [2B5B] [32]
Metipranolol DMJMVKI Moderate Increased risk of cardiac depression by the combination of Nifedipine and Metipranolol. Glaucoma [9C61] [64]
Levobetaxolol DMSREPX Moderate Increased risk of cardiac depression by the combination of Nifedipine and Levobetaxolol. Glaucoma [9C61] [64]
Levobunolol DMTNFCQ Moderate Increased risk of cardiac depression by the combination of Nifedipine and Levobunolol. Glaucoma [9C61] [64]
Carvedilol DMHTEAO Moderate Increased risk of cardiac depression by the combination of Nifedipine and Carvedilol. Heart failure [BD10-BD1Z] [60]
Boceprevir DMBSHMF Moderate Decreased metabolism of Nifedipine caused by Boceprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [65]
Simeprevir DMLUA9D Moderate Decreased metabolism of Nifedipine caused by Simeprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [66]
Telaprevir DMMRV29 Moderate Decreased metabolism of Nifedipine caused by Telaprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [65]
Daclatasvir DMSFK9V Moderate Decreased metabolism of Nifedipine caused by Daclatasvir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [49]
Rifapentine DMCHV4I Major Increased metabolism of Nifedipine caused by Rifapentine mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [31]
Procarbazine DMIK367 Moderate Additive hypotensive effects by the combination of Nifedipine and Procarbazine. Hodgkin lymphoma [2B30] [55]
MK-1439 DM215WE Minor Decreased metabolism of Nifedipine caused by MK-1439 mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [67]
Fosamprenavir DM4W9B3 Moderate Decreased metabolism of Nifedipine caused by Fosamprenavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [68]
Cobicistat DM6L4H2 Moderate Decreased clearance of Nifedipine due to the transporter inhibition by Cobicistat. Human immunodeficiency virus disease [1C60-1C62] [69]
Dolutegravir DMCZGRE Minor Decreased metabolism of Nifedipine caused by Dolutegravir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [70]
Saquinavir DMG814N Moderate Decreased metabolism of Nifedipine caused by Saquinavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [71]
Etravirine DMGV8QU Moderate Increased metabolism of Nifedipine caused by Etravirine mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [72]
Rilpivirine DMJ0QOW Moderate Decreased metabolism of Nifedipine caused by Rilpivirine mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [49]
Darunavir DMN3GCH Moderate Decreased metabolism of Nifedipine caused by Darunavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [73]
Maraviroc DMTL94F Moderate Decreased clearance of Nifedipine due to the transporter inhibition by Maraviroc. Human immunodeficiency virus disease [1C60-1C62] [74]
Acebutolol DM0TI4U Moderate Increased risk of cardiac depression by the combination of Nifedipine and Acebutolol. Hypertension [BA00-BA04] [60]
Aliskiren DM1BV7W Moderate Decreased clearance of Nifedipine due to the transporter inhibition by Aliskiren. Hypertension [BA00-BA04] [75]
Penbutolol DM4ES8F Moderate Increased risk of cardiac depression by the combination of Nifedipine and Penbutolol. Hypertension [BA00-BA04] [60]
Nebivolol DM7F1PA Moderate Increased risk of cardiac depression by the combination of Nifedipine and Nebivolol. Hypertension [BA00-BA04] [60]
Tolvaptan DMIWFRL Moderate Decreased clearance of Nifedipine due to the transporter inhibition by Tolvaptan. Hypo-osmolality/hyponatraemia [5C72] [76]
Retapamulin DM9JXB7 Minor Decreased metabolism of Nifedipine caused by Retapamulin mediated inhibition of CYP450 enzyme. Impetigo [1B72] [77]
Lesinurad DMUR64T Moderate Increased metabolism of Nifedipine caused by Lesinurad mediated induction of CYP450 enzyme. Inborn purine/pyrimidine/nucleotide metabolism error [5C55] [78]
Suvorexant DM0E6S3 Moderate Decreased metabolism of Nifedipine caused by Suvorexant mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [49]
Amobarbital DM0GQ8N Moderate Increased metabolism of Nifedipine caused by Amobarbital mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [79]
ITI-007 DMUQ1DO Moderate Decreased metabolism of Nifedipine caused by ITI-007 mediated inhibition of CYP450 enzyme. Insomnia [7A00-7A0Z] [80]
Naloxegol DML0B41 Minor Decreased clearance of Nifedipine due to the transporter inhibition by Naloxegol. Large intestine motility disorder [DB32] [81]
Pemigatinib DM819JF Moderate Decreased metabolism of Nifedipine caused by Pemigatinib mediated inhibition of CYP450 enzyme. Liver cancer [2C12] [32]
PF-06463922 DMKM7EW Moderate Increased metabolism of Nifedipine caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [82]
Osimertinib DMRJLAT Moderate Decreased metabolism of Nifedipine caused by Osimertinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [83]
Selpercatinib DMZR15V Moderate Decreased metabolism of Nifedipine caused by Selpercatinib mediated inhibition of CYP450 enzyme. Lung cancer [2C25] [32]
Idelalisib DM602WT Moderate Decreased metabolism of Nifedipine caused by Idelalisib mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [84]
GDC-0199 DMH0QKA Major Decreased metabolism of Nifedipine caused by GDC-0199 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [49]
IPI-145 DMWA24P Moderate Decreased metabolism of Nifedipine caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [85]
Acalabrutinib DM7GCVW Moderate Decreased metabolism of Nifedipine caused by Acalabrutinib mediated inhibition of CYP450 enzyme. Mature B-cell lymphoma [2A85] [86]
Ibrutinib DMHZCPO Moderate Decreased metabolism of Nifedipine caused by Ibrutinib mediated inhibition of CYP450 enzyme. Mature B-cell lymphoma [2A85] [87]
Arry-162 DM1P6FR Moderate Decreased clearance of Nifedipine due to the transporter inhibition by Arry-162. Melanoma [2C30] [49]
Selumetinib DMC7W6R Moderate Decreased metabolism of Nifedipine caused by Selumetinib mediated inhibition of CYP450 enzyme. Melanoma [2C30] [88]
LGX818 DMNQXV8 Moderate Increased metabolism of Nifedipine caused by LGX818 mediated induction of CYP450 enzyme. Melanoma [2C30] [89]
Dabrafenib DMX6OE3 Moderate Increased metabolism of Nifedipine caused by Dabrafenib mediated induction of CYP450 enzyme. Melanoma [2C30] [32]
Ubrogepant DM749I3 Moderate Decreased metabolism of Nifedipine caused by Ubrogepant mediated inhibition of CYP450 enzyme. Migraine [8A80] [90]
Exjade DMHPRWG Moderate Decreased metabolism of Nifedipine caused by Exjade mediated inhibition of CYP450 enzyme. Mineral absorption/transport disorder [5C64] [91]
Flibanserin DM70DTN Moderate Decreased metabolism of Nifedipine caused by Flibanserin mediated inhibition of CYP450 enzyme. Mood disorder [6A60-6E23] [92]
Panobinostat DM58WKG Moderate Decreased metabolism of Nifedipine caused by Panobinostat mediated inhibition of CYP450 enzyme. Multiple myeloma [2A83] [93]
Siponimod DM2R86O Major Increased risk of atrioventricular block by the combination of Nifedipine and Siponimod. Multiple sclerosis [8A40] [49]
Fingolimod DM5JVAN Moderate Increased risk of bradycardia by the combination of Nifedipine and Fingolimod. Multiple sclerosis [8A40] [94]
Ozanimod DMT6AM2 Moderate Increased risk of bradycardia by the combination of Nifedipine and Ozanimod. Multiple sclerosis [8A40] [95]
Romidepsin DMT5GNL Moderate Decreased clearance of Nifedipine due to the transporter inhibition by Romidepsin. Mycosis fungoides [2B01] [96]
Fedratinib DM4ZBK6 Moderate Decreased metabolism of Nifedipine caused by Fedratinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [32]
Nilotinib DM7HXWT Moderate Decreased clearance of Nifedipine due to the transporter inhibition by Nilotinib. Myeloproliferative neoplasm [2A20] [97]
Ruxolitinib DM7Q98D Minor Decreased metabolism of Nifedipine caused by Ruxolitinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [32]
Dasatinib DMJV2EK Moderate Decreased metabolism of Nifedipine caused by Dasatinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [98]
Entrectinib DMMPTLH Moderate Decreased metabolism of Nifedipine caused by Entrectinib mediated inhibition of CYP450 enzyme. Non-small cell lung cancer [2C25] [99]
S-297995 DM26IH8 Moderate Decreased clearance of Nifedipine due to the transporter inhibition by S-297995. Opioid use disorder [6C43] [32]
Olaparib DM8QB1D Moderate Decreased metabolism of Nifedipine caused by Olaparib mediated inhibition of CYP450 enzyme. Ovarian cancer [2C73] [100]
Rucaparib DM9PVX8 Moderate Decreased metabolism of Nifedipine caused by Rucaparib mediated inhibition of CYP450 enzyme. Ovarian cancer [2C73] [101]
Safinamide DM0YWJC Moderate Additive hypotensive effects by the combination of Nifedipine and Safinamide. Parkinsonism [8A00] [55]
Istradefylline DM20VSK Moderate Decreased metabolism of Nifedipine caused by Istradefylline mediated inhibition of CYP450 enzyme. Parkinsonism [8A00] [102]
Rasagiline DM3WKQ4 Moderate Additive hypotensive effects by the combination of Nifedipine and Rasagiline. Parkinsonism [8A00] [55]
Pimavanserin DMR7IVC Moderate Decreased metabolism of Nifedipine caused by Pimavanserin mediated inhibition of CYP450 enzyme. Parkinsonism [8A00] [103]
Abametapir DM2RX0I Moderate Decreased metabolism of Nifedipine caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [104]
Lefamulin DME6G97 Moderate Decreased metabolism of Nifedipine caused by Lefamulin mediated inhibition of CYP450 enzyme. Pneumonia [CA40] [105]
Ergonovine DM0VEC1 Moderate Decreased metabolism of Nifedipine caused by Ergonovine mediated inhibition of CYP450 enzyme. Postpartum haemorrhage [JA43] [106]
Lonafarnib DMGM2Z6 Major Decreased metabolism of Nifedipine caused by Lonafarnib mediated inhibition of CYP450 enzyme. Premature ageing appearance [LD2B] [107]
Enzalutamide DMGL19D Major Increased metabolism of Nifedipine caused by Enzalutamide mediated induction of CYP450 enzyme. Prostate cancer [2C82] [31]
Darolutamide DMV7YFT Minor Decreased clearance of Nifedipine due to the transporter inhibition by Darolutamide. Prostate cancer [2C82] [108]
Dutasteride DMQ4TJK Moderate Decreased metabolism of Nifedipine caused by Dutasteride mediated inhibition of CYP450 enzyme. Prostate hyperplasia [GA90] [109]
Ustekinumab DMHTYK3 Moderate Altered metabolism of Nifedipine due to Ustekinumab alters the formation of CYP450 enzymes. Psoriasis [EA90] [32]
Ixekizumab DMXW92T Moderate Altered metabolism of Nifedipine due to Ixekizumab alters the formation of CYP450 enzymes. Psoriasis [EA90] [32]
Levomepromazine DMIKFEL Moderate Additive hypotensive effects by the combination of Nifedipine and Levomepromazine. Psychotic disorder [6A20-6A25] [57]
Axitinib DMGVH6N Moderate Decreased metabolism of Nifedipine caused by Axitinib mediated inhibition of CYP450 enzyme. Renal cell carcinoma [2C90] [32]
Temsirolimus DMS104F Moderate Increased plasma concentrations of Nifedipine and Temsirolimus due to competitive inhibition of the same metabolic pathway. Renal cell carcinoma [2C90] [110]
Upadacitinib DM32B5U Moderate Decreased metabolism of Nifedipine caused by Upadacitinib mediated inhibition of CYP450 enzyme. Rheumatoid arthritis [FA20] [111]
Tocilizumab DM7J6OR Moderate Altered metabolism of Nifedipine due to Tocilizumab alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [32]
Canakinumab DM8HLO5 Moderate Altered metabolism of Nifedipine due to Canakinumab alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [32]
Rilonacept DMGLUQS Moderate Altered metabolism of Nifedipine due to Rilonacept alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [32]
Golimumab DMHZV7X Moderate Altered metabolism of Nifedipine due to Golimumab alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [32]
Sarilumab DMOGNXY Moderate Altered metabolism of Nifedipine due to Sarilumab alters the formation of CYP450 enzymes. Rheumatoid arthritis [FA20] [32]
Quetiapine DM1N62C Moderate Decreased metabolism of Nifedipine caused by Quetiapine mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [112]
Aripiprazole DM3NUMH Moderate Additive hypotensive effects by the combination of Nifedipine and Aripiprazole. Schizophrenia [6A20] [57]
Iloperidone DM6AUFY Moderate Additive hypotensive effects by the combination of Nifedipine and Iloperidone. Schizophrenia [6A20] [57]
Paliperidone DM7NPJS Moderate Additive hypotensive effects by the combination of Nifedipine and Paliperidone. Schizophrenia [6A20] [57]
Molindone DMAH70G Moderate Additive hypotensive effects by the combination of Nifedipine and Molindone. Schizophrenia [6A20] [57]
Thiothixene DMDINC4 Moderate Additive hypotensive effects by the combination of Nifedipine and Thiothixene. Schizophrenia [6A20] [57]
Amisulpride DMSJVAM Moderate Additive hypotensive effects by the combination of Nifedipine and Amisulpride. Schizophrenia [6A20] [57]
Asenapine DMSQZE2 Moderate Additive hypotensive effects by the combination of Nifedipine and Asenapine. Schizophrenia [6A20] [57]
Voxelotor DMCS6M5 Moderate Decreased metabolism of Nifedipine caused by Voxelotor mediated inhibition of CYP450 enzyme. Sickle-cell disorder [3A51] [113]
LDE225 DMM9F25 Moderate Decreased metabolism of Nifedipine caused by LDE225 mediated inhibition of CYP450 enzyme. Skin cancer [2C30-2C37] [114]
Telotristat ethyl DMDIYFZ Moderate Increased metabolism of Nifedipine caused by Telotristat ethyl mediated induction of CYP450 enzyme. Small intestine developmental anomaly [DA90] [32]
Larotrectinib DM26CQR Moderate Decreased metabolism of Nifedipine caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [49]
Docetaxel DMDI269 Moderate Decreased metabolism of Nifedipine caused by Docetaxel mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [115]
Trabectedin DMG3Y89 Moderate Decreased metabolism of Nifedipine caused by Trabectedin mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [32]
Armodafinil DMGB035 Moderate Increased metabolism of Nifedipine caused by Armodafinil mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [49]
LEE011 DMMX75K Moderate Decreased metabolism of Nifedipine caused by LEE011 mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [49]
Taxol DMUOT9V Moderate Decreased metabolism of Nifedipine caused by Taxol mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [116]
Pitolisant DM8RFNJ Moderate Increased metabolism of Nifedipine caused by Pitolisant mediated induction of CYP450 enzyme. Somnolence [MG42] [32]
Fostamatinib DM6AUHV Moderate Decreased metabolism of Nifedipine caused by Fostamatinib mediated inhibition of CYP450 enzyme. Thrombocytopenia [3B64] [117]
Lusutrombopag DMH6IKO Moderate Decreased clearance of Nifedipine due to the transporter inhibition by Lusutrombopag. Thrombocytopenia [3B64] [101]
Apixaban DM89JLN Moderate Decreased clearance of Nifedipine due to the transporter inhibition by Apixaban. Thrombosis [DB61-GB90] [32]
Saxagliptin DMGXENV Moderate Decreased metabolism of Nifedipine caused by Saxagliptin mediated inhibition of CYP450 enzyme. Type 2 diabetes mellitus [5A11] [32]
Trimeprazine DMEMV9D Moderate Additive hypotensive effects by the combination of Nifedipine and Trimeprazine. Vasomotor/allergic rhinitis [CA08] [118]
Betrixaban DM2C4RF Moderate Decreased clearance of Nifedipine due to the transporter inhibition by Betrixaban. Venous thromboembolism [BD72] [119]
⏷ Show the Full List of 156 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Allura red AC dye E00338 33258 Colorant
D&C red no. 27 E00381 83511 Colorant
Ethyl acrylate E00191 8821 Film/membrane-forming agent; Flavoring agent
FD&C blue no. 1 E00263 19700 Colorant
FD&C blue no. 2 E00446 2723854 Colorant
Hydrazine yellow E00409 164825 Colorant
Isopropyl alcohol E00070 3776 Antimicrobial preservative; Solvent
Menthol E00050 1254 Flavoring agent
methylparaben E00149 7456 Antimicrobial preservative
Potassium chloride E00074 4873 Tonicity agent
Propyl 4-hydroxybenzoate E00141 7175 Antimicrobial preservative
Saccharin sodium anhydrous E00443 656582 Flavoring agent
Sodium lauryl sulfate E00464 3423265 Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Sunset yellow FCF E00255 17730 Colorant
Ammonia E00007 222 Alkalizing agent
Beta-D-lactose E00099 6134 Diluent; Dry powder inhaler carrier; Lyophilization aid
Butyl alcohol E00011 263 Flavoring agent; Solvent
Crospovidone E00626 Not Available Disintegrant
Eisenoxyd E00585 56841934 Colorant
Ferric hydroxide oxide yellow E00539 23320441 Colorant
Ferric trioxide E00437 518696 Colorant
Ferrosoferric oxide E00231 14789 Colorant
Glycerin E00026 753 Antimicrobial preservative; Emollient; Flavoring agent; Humectant; Lubricant; Plasticizing agent; Solvent; Suppository base; Tonicity agent; Viscosity-controlling agent
Hexahydric alcohol E00083 5780 Diluent; Flavoring agent; Humectant; Plasticizing agent
Hypromellose E00634 Not Available Coating agent
Isobutyl alcohol E00130 6560 Flavoring agent; Solvent
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Methyl methacrylate E00133 6658 Film/membrane-forming agent
Polyethylene glycol 3350 E00652 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyethylene glycol 400 E00653 Not Available Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polysorbate 20 E00664 Not Available Dispersing agent; Emollient; Emulsifying agent; Plasticizing agent; Solubilizing agent; Surfactant; Suspending agent
Polyvinyl alcohol E00666 Not Available Coating agent; Emulsion stabilizing agent; Film/Membrane-forming agent
Povidone E00667 Not Available Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Propylene glycol E00040 1030 Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Silicon dioxide E00670 Not Available Anticaking agent; Opacifying agent; Viscosity-controlling agent
Sodium chloride E00077 5234 Diluent; Tonicity agent
Soybean lecithin E00637 Not Available Other agent
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Triacetin E00080 5541 Humectant; Plasticizing agent; Solvent
Vinylpyrrolidone E00668 Not Available Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Water E00035 962 Solvent
⏷ Show the Full List of 43 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Nifedipine 10 mg capsule 10 mg Oral Capsule Oral
Nifedipine 60 mg tablet 60 mg 24 HR Extended Release Oral Tablet Oral
Nifedipine 30 mg tablet 30 mg 24 HR Extended Release Oral Tablet Oral
Nifedipine 20 mg capsule 20 mg Oral Capsule Oral
Nifedipine 90 mg tablet 90 mg 24 HR Extended Release Oral Tablet Oral
Nifedipine 30 mg tablet 30 mg Oral Tablet Oral
Nifedipine 30 mg tablet 30 mg Osmotic 24 HR Extended Release Oral Tablet Oral
Nifedipine 60 mg tablet 60 mg Osmotic 24 HR Extended Release Oral Tablet Oral
Nifedipine 90 mg tablet 90 mg Osmotic 24 HR Extended Release Oral Tablet Oral
Nifedipine 30 mg tablet 30 mg 24 HR Extended Release Tablet Oral
Nifedipine 60 mg tablet 60 mg 24 HR Extended Release Tablet Oral
Nifedipine 90 mg tablet 90 mg 24 HR Extended Release Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

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