Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEHI15)

Drug Name

Indole N -acetamide Drug Info

Synonyms

1H-Indole-1-acetamide; 2-(1H-indol-1-yl)acetamide; 39597-63-2; 2-indol-1-ylacetamide; 2(N-indolyl) acetamide; 2-(N-indolyl) acetamide; AC1N9C0U; SCHEMBL1519806; CHEMBL3252106; MolPort-003-001-159; IUUZMSMGSOUFTO-UHFFFAOYSA-N; ZINC6393531; STK319340; AKOS003406817; MCULE-8299376429; VU0526183-1

Indication

Disease Entry	ICD 11	Status	REF
Hepatovirus infection	1E51	Investigative	[1]

Cross-matching ID

PubChem CID: 4408257
TTD Drug ID: DMEHI15

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Human immunodeficiency virus Reverse transcriptase (HIV RT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[2]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[3]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[4]
Tenofovir	DM1IS6U	Chronic hepatitis B virus infection		Approved	[2]
Lamivudine	DMI347A	Chronic HBV infection	1E51.0Z	Approved	[5]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[6]
Delavirdine	DM3NF5G	Human immunodeficiency virus infection	1C62	Approved	[5]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[5]
Rilpivirine	DMJ0QOW	Human immunodeficiency virus infection	1C62	Approved	[1]
Etravirine	DMGV8QU	Human immunodeficiency virus-1 infection	1C62	Approved	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human immunodeficiency virus Reverse transcriptase (HIV RT)	TT84ETX	POL_HV1B1	Inhibitor	[1]

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References

1	Emerging antiviral drugs. Expert Opin Emerg Drugs. 2008 Sep;13(3):393-416.
2	Antiviral drugs in current clinical use. J Clin Virol. 2004 Jun;30(2):115-33.
3	HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism.Nat Struct Mol Biol.2012 Jan 22;19(2):253-9.
4	A peptide inhibitor of HIV-1 reverse transcriptase using alpha,beta-dehydro residues: a structure-based computer model. J Biomol Struct Dyn. 1998 Oct;16(2):347-54.
5	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6	Quadruple nucleos(t)ide reverse transcriptase inhibitors-only regimen of tenofovir plus zidovudine/lamivudine/abacavir in heavily pre-treated HIV-1 infected patients: salvage therapy or backbone only Curr HIV Res. 2009 May;7(3):320-6.
7	2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.