Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEOP4J)

Drug Name

8-DEOXYGARTANIN Drug Info

Synonyms

8-Desoxygartanin; 8-DEOXYGARTANIN; 33390-41-9; CHEMBL488606; 1,3,5-trihydroxy-2,4-bis(3-methylbut-2-enyl)xanthen-9-one; 1,3,5-trihydroxy-2,4-bis(3-methylbut-2-en-1-yl)-9h-xanthen-9-one; 9H-Xanthen-9-one, 1,3,5-trihydroxy-2,4-bis(3-methyl-2-butenyl)-; Deoxygartinin; Desoxygartanin,8-; NSC692944; AC1L944B; SCHEMBL17056909; CTK8C7216; MolPort-039-052-631; ZINC5849312; BDBM50311742; AKOS028108663; NSC-692944; FT-0686569; 390D419; 1,3,5-Trihydroxy-2,4-bis(3-methyl-2-butenyl)-9H-xanthen-9-one

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 392450
CAS Number: CAS 33390-41-9
TTD Drug ID: DMEOP4J

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Influenza Neuraminidase (Influ NA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oseltamivir	DMGO72P	Influenza	1E30-1E32	Approved	[2]
Zanamivir	DMFMBZ4	Influenza	1E30-1E32	Approved	[2]
Peramivir	DMNXY5K	Influenza virus infection	1E30-1E32	Approved	[3]
UX-001	DMD2O0L	Hereditary inclusion body myositis	4A41.2	Phase 3	[4]
CS-8958	DM4CSDH	Influenza virus infection	1E30-1E32	Phase 3	[3]
DAS-181	DM0Y8JP	Influenza virus infection	1E30-1E32	Phase 2	[5]
Lactose	DMO4GPK	Discovery agent	N.A.	Phase 1	[4]
GS-3435	DMV7JC6	Influenza virus infection	1E30-1E32	Terminated	[6]
BCX-140	DMBJERO	Influenza virus infection	1E30-1E32	Terminated	[7]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Influenza Neuraminidase (Influ NA)	TT50QJ3	NRAM_I33A0	Inhibitor	[1]

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References

1	Xanthones with neuraminidase inhibitory activity from the seedcases of Garcinia mangostana. Bioorg Med Chem. 2010 Sep 1;18(17):6258-64.
2	Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res. 2008 Apr;78(1):91-102.
3	Developing new antiviral agents for influenza treatment: what does the future hold Clin Infect Dis. 2009 Jan 1;48 Suppl 1:S3-13.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5	Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein. PLoS One. 2009 Nov 6;4(11):e7838.
6	US patent application no. 2010,0081,713, Compositions and methods for treating viral infections.
7	CN patent application no. 104447481, Benzoic acid thiourea anti-influenza virus compounds as well as preparation method and use thereof.