Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFMBZ4)

Drug Name

Zanamivir Drug Info

Synonyms

zanamivir; 139110-80-8; Relenza; 4-Guanidino-Neu5Ac2en; GANA; Zanamavir; MODIFIED SIALIC ACID; GG167; UNII-L6O3XI777I; GG 167; GR-121167X; Zanamivir (Relenza); Relenza (TN); 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid; GR 121167X; CHEMBL222813; L6O3XI777I; ZMR; CHEBI:50663; GANA (inhibitor); 5-Acetamido-2,6-anhydro-3,4,5-trideoxy-4-guanidino-D-glycero-D-galacto-non-2-enonic acid; GNA; AK163166; GG-167; DSSTox_CID_3749; DSSTox_RID_77184; DSSTox_GSID_23749; Zanamivir [USAN:INN:BAN]; HSDB 7437; C12H20N4O7; GANA; Zanamivir hydrate; GR121167X; Zanamivir (USAN/INN); (2R,3R,4S)-3-acetamido-4-(diaminomethylideneamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid; 4-Guanidino-NeueAc2en; 5-(acetylamino)-4-{[amino(imino)methyl]amino}-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid; ZNV; 4-guanidino-Neu5Ac2en; BAC-zanamivir

Indication

Disease Entry	ICD 11	Status	REF
Influenza virus infection	1E30-1E32	Approved	[1] , [2]

Therapeutic Class

Antiviral Agents

Cross-matching ID

PubChem CID: 60855
ChEBI ID: CHEBI:50663
CAS Number: CAS 139110-80-8
TTD Drug ID: DMFMBZ4
VARIDT Drug ID: DR00960

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Influenza Neuraminidase (Influ NA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oseltamivir	DMGO72P	Influenza virus infection	1E30-1E32	Approved	[3]
Peramivir	DMNXY5K	Influenza virus infection	1E30-1E32	Approved	[5]
UX-001	DMD2O0L	Hereditary inclusion body myositis	4A41.2	Phase 3	[6]
CS-8958	DM4CSDH	Influenza virus infection	1E30-1E32	Phase 3	[5]
DAS-181	DM0Y8JP	Influenza virus infection	1E30-1E32	Phase 2	[7]
GS-3435	DMV7JC6	Influenza virus infection	1E30-1E32	Terminated	[8]
BCX-140	DMBJERO	Influenza virus infection	1E30-1E32	Terminated	[9]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[6]
Fucose	DMAHMSV	N. A.	N. A.	Investigative	[6]
Apigenin	DMI3491	Discovery agent	N.A.	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Influenza Neuraminidase (Influ NA)	TT50QJ3	NRAM_I33A0	Inhibitor	[3] , [4]

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References

1	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3	Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res. 2008 Apr;78(1):91-102.
4	Antiviral agents for influenza, hepatitis C and herpesvirus, enterovirus and rhinovirus infections. Med J Aust. 2001 Jul 16;175(2):112-6.
5	Developing new antiviral agents for influenza treatment: what does the future hold Clin Infect Dis. 2009 Jan 1;48 Suppl 1:S3-13.
6	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
7	Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein. PLoS One. 2009 Nov 6;4(11):e7838.
8	US patent application no. 2010,0081,713, Compositions and methods for treating viral infections.
9	CN patent application no. 104447481, Benzoic acid thiourea anti-influenza virus compounds as well as preparation method and use thereof.
10	Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. Bioorg Med Chem. 2009 Oct 1;17(19):6816-23.