Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMG6NI8)

Drug Name

SSR-125329A Drug Info

Synonyms

SR-125329; N-[3-[4-(2-Adamantyl)-3,5-dichlorophenyl]-2(Z)-propenyl]-N-cyclohexyl-N-ethylamine

Indication

Disease Entry	ICD 11	Status	REF
Immune System disease	4A01-4B41	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Opioid receptor sigma 1 (OPRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dextromethorphan	DMUDJZM	Allergic rhinitis	CA08.0	Approved	[2]
Dextromethorphan Polistirex	DMEHCY5	Dry cough	MD12	Approved	[3]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[4]
AVP-786	DMV1SOR	Alzheimer disease	8A20	Phase 3	[5]
ADX N05	DMLBYRA	Mood disorder	6A60-6E23	Phase 3	[6]
Igmesine	DMH97XA	Major depressive disorder	6A70.3	Phase 2	[7]
OPC-14523	DMB1WF3	Bulimia nervosa	6B81	Phase 2	[8]
ANAVEX 2-73	DM67OU4	Alzheimer disease	8A20	Phase 1	[9]
SSR-125047	DMSUFW6	Schizophrenia	6A20	Phase 1	[10]
SA-5845	DM6XZRL	Central nervous system disease	8A04-8D87	Phase 1	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	SSR125329A, a high affinity sigma receptor ligand with potent anti-inflammatory properties. Eur J Pharmacol. 2002 Dec 5;456(1-3):123-31.
2	Dextromethorphan/quinidine: AVP 923, dextromethorphan/cytochrome P450-2D6 inhibitor, quinidine/dextromethorphan. Drugs R D. 2005;6(3):174-7.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031127)
5	Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.
6	Clinical pipeline report, company report or official report of SK BioPhamaceuticals.
7	Antiamnesic and neuroprotective effects of donepezil against learning impairments induced in mice by exposure to carbon monoxide gas. J Pharmacol Exp Ther. 2006 Jun;317(3):1307-19.
8	Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523. Neuropharmacology. 2001 Dec;41(8):976-88.
9	2011 Pipeline of Anavex.
10	The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22.
11	Tumor imaging with 2 sigma-receptor ligands, 18F-FE-SA5845 and 11C-SA4503: a feasibility study. J Nucl Med. 2004 Nov;45(11):1939-45.