Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMG6TOA)

Drug Name

RTI-4229-982 Drug Info

Synonyms

Metabotropic glutamate receptor 5 antagonists (neurological disease); Metabotropic glutamate receptor 5 antagonists (neurological disease), Research Triangle Institute

Indication

Disease Entry	ICD 11	Status	REF
Neurological disorder	6B60	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMG6TOA

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Metabotropic glutamate receptor 5 (mGluR5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AFQ056	DMMHSLC	Fragile X syndrome	LD55	Phase 2/3	[2]
ADX-48621	DM6GTMD	Parkinson disease	8A00.0	Phase 2/3	[3]
RG-7090	DMX8JYN	Fragile X syndrome	LD55	Phase 2	[4]
STX-107	DMLNKX7	Autism spectrum disorder	6A02	Phase 2	[5]
ADX10059	DMGVKHQ	Anxiety disorder	6B00-6B0Z	Phase 2	[6]
McN3377	DMTCADJ	Fragile X syndrome	LD55	Phase 1/2	[7]
MK-3328	DMW2O5D	Alzheimer disease	8A20	Phase 1	[1]
[3H]fenobam	DMBOXA1	Allodynia	MB40.1	Phase 1	[8]
RG7342	DMIW5NG	Schizophrenia	6A20	Phase 1	[9]
BMS-984923	DMFNDUL	Alzheimer disease	8A20	Phase 1	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Metabotropic glutamate receptor 5 (mGluR5)	TTHS256	GRM5_HUMAN	Antagonist	[1]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 293).
2	Metabolism and disposition of the metabotropic glutamate receptor 5 antagonist (mGluR5) mavoglurant (AFQ056) in healthy subjects. Drug Metab Dispos. 2013 Sep;41(9):1626-41.
3	Pipeline of Addex Pharma. Addex Pharma. 2009.
4	The challenges of clinical trials in fragile X syndrome. Psychopharmacology (Berl) 2014; 231(6): 1237-1250.
5	Social Communication is an Emerging Target for Pharmacotherapy in Autism Spectrum Disorder - A Review of the Literature on Potential Agents. J Can Acad Child Adolesc Psychiatry. 2014 February; 23(1):20-30.
6	A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and... Gut. 2009 Sep;58(9):1192-9.
7	Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.
8	Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agon... J Pharmacol Exp Ther. 2005 Nov;315(2):711-21.
9	Clinical pipeline report, company report or official report of Roche.
10	Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer's Mouse Phenotypes. Cell Rep. 2017 Jul 5;20(1):76-88.