Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGFABM)

• Drug Name: BC-3205 Drug Info
• Synonyms: BC-3205 (oral); BC-3205 (oral), Nabriva; Pleuromutilin (oral, respiratory infection), Nabriva

Indication

Disease Entry	ICD 11	Status	REF
Respiratory tract infection	CA45	Phase 1	[1]

• Cross-matching ID:
  PubChem CID: 44205184
  TTD Drug ID: DMGFABM

Molecule-Related Drug Atlas

Drug(s) Targeting Bacterial 50S ribosomal RNA (Bact 50S rRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[3]
Telithromycin	DMZ4P3A	Bacterial infection	1A00-1C4Z	Approved	[4]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[5]
Dirithromycin	DM0D9YJ	Bacterial infection	1A00-1C4Z	Approved	[6]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[5]
Zithromax	DMN4H2O	Syphilis infection	1A6Z	Approved	[7]
Troleandomycin	DMUZNIG	Bacterial infection	1A00-1C4Z	Approved	[8]
Retapamulin	DM9JXB7	Impetigo	1B72	Approved	[9]
Dalfopristin	DM4LTKV	Bacterial infection	1A00-1C4Z	Approved	[10]
Tedizolid	DMG2SKR	Skin infection	1F28-1G0Z	Approved	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial 50S ribosomal RNA (Bact 50S rRNA)	TTUWYEA	NOUNIPROTAC	Modulator	[2]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029896)
• [2] Disk Diffusion and MIC Quality Control Ranges for BC-3205 and BC-3781, Two Novel Pleuromutilin Antibiotics. J Clin Microbiol. 2012 October; 50(10): 3361-3364.
• [3] A synthetic alanyl-initiator tRNA with initiator tRNA properties as determined by fluorescence measurements: comparison to a synthetic alanyl-elongator tRNA. Nucleic Acids Res. 1991 Oct 25;19(20):5749-54.
• [4] An examination of the differential sensitivity to ketolide antibiotics in ermB strains of Streptococcus pyogenes and Streptococcus pneumoniae. Curr Microbiol. 2004 Oct;49(4):239-47.
• [5] Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature. 2001 Oct 25;413(6858):814-21.
• [6] Review of macrolides and ketolides: focus on respiratory tract infections. Drugs. 2001;61(4):443-98.
• [7] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [8] Depression of colony formation by human thymus-derived lymphocytes with rifampin and other antimicrobial agents. J Infect Dis. 1981 Jun;143(6):832-5.
• [9] Retapamulin inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells. Antimicrob Agents Chemother. 2007 Sep;51(9):3385-7.
• [10] The streptogramin antibiotics: update on their mechanism of action. Expert Opin Investig Drugs. 1998 Apr;7(4):591-9.
• [11] 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.