Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMH01JV)

• Drug Name: cloprostenol Drug Info
• Synonyms: ICI 80996

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5311053
  CAS Number: CAS 54276-21-0
  TTD Drug ID: DMH01JV

Molecule-Related Drug Atlas

Drug(s) Targeting Prostaglandin E2 receptor EP1 (PTGER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AS-013	DMD7XWS	Thrombosis	DB61-GB90	Phase 3	[4]
PGF2alpha	DM4XAU7	Solid tumour/cancer	2A00-2F9Z	Clinical trial	[5]
BUTAPROST	DMVYNJZ	Discovery agent	N.A.	Patented	[6]
ZD6416	DM46JIR	Pain	MG30-MG3Z	Discontinued in Phase 2	[7]
ONO-8130	DMBDCL4	Pollakiuria	MF50.1	Terminated	[8]
ONO-8711	DM2VRK7	Pain	MG30-MG3Z	Terminated	[9]
U46619	DM13FX4	Discovery agent	N.A.	Investigative	[5]
carbacyclin	DMMBQYE	Discovery agent	N.A.	Investigative	[2]
PGD2	DMYDW6J	Discovery agent	N.A.	Investigative	[3]
M&B 28767	DMJQG82	Discovery agent	N.A.	Investigative	[10]

Drug(s) Targeting Prostaglandin D2 receptor (PTGDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LAROPIPRANT	DM5FABJ	Coronary heart disease	BA80.Z	Phase 4	[11]
Setipiprant	DMZ61IA	Asthma	CA23	Phase 3	[12]
QAW-039	DMPCFXN	Asthma	CA23	Phase 3	[13]
AMG 853	DM973N4	Asthma	CA23	Phase 2	[14]
ONO-4053	DMX4MVP	Allergic rhinitis	CA08.0	Phase 2	[15]
TS-022	DMMNXIW	Atopic dermatitis	EA80	Phase 2	[16]
S-555739	DMXDVNZ	Allergy	4A80-4A85	Phase 2	[17]
MK-1029	DM8ZTW7	Asthma	CA23	Phase 2	[18]
SAR-389644	DMA6O9R	Allergic rhinitis	CA08.0	Phase 1	[19]
192C86	DMQ8NTZ	Thrombosis	DB61-GB90	Phase 1	[20]

Drug(s) Targeting Prostaglandin F2-alpha receptor (PTGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[6]
Latanoprost	DMI5OXG	Ocular hypertension	9C61.01	Approved	[21]
BOL-303259-X	DM2EXC5	Open-angle glaucoma	9C61	Approved	[22]
Tafluprost	DMFC41K	Glaucoma/ocular hypertension	9C61	Approved	[23]
Carboprost Tromethamine	DMS3508	Abortion	JA00	Approved	[24]
Travoprost	DM20K91	Ocular hypertension	9C61.01	Approved	[25]
LAROPIPRANT	DM5FABJ	Coronary heart disease	BA80.Z	Phase 4	[11]
PGF2ALPHA-IE	DM5DAP3	Glaucoma/ocular hypertension	9C61	Phase 3	[26]
ONO-9054	DM5O6GC	Glaucoma/ocular hypertension	9C61	Phase 2	[27]
PDC-41	DM74YO8	Dysmenorrhea	GA34.3	Phase 1	[28]

Drug(s) Targeting Thromboxane A2 receptor (TBXA2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alprostadil	DMWH7NQ	Aorta coarctation		Approved	[29]
Ridogrel	DMWH9CN	Acute myocardial infarction	BA41	Approved	[30]
LAROPIPRANT	DM5FABJ	Coronary heart disease	BA80.Z	Phase 4	[11]
Ramatroban	DMB8UQ3	Perennial allergic rhinitis	CA08.03	Phase 2/3	[31]
KP-496	DMCO8UZ	Asthma	CA23	Phase 2	[32]
FK-070	DMJSD5W	Angina pectoris	BA40	Phase 2	[33]
TAK-128	DMHPEFS	Diabetic neuropathy	8C0Z	Phase 2	[34]
Ifetroban sodium	DMZP84Y	Thrombosis	DB61-GB90	Phase 2	[35]
Ifetroban	DMEV39E	Aspirin-induced asthma	CA23.20	Phase 2	[36]
YM-57158	DMS31YW	Allergic rhinitis	CA08.0	Phase 1	[37]

Drug(s) Targeting Prostaglandin E2 receptor EP3 (PTGER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
16,16-dimethyl-PGE2	DMNF38S	Stem cell engraftment	QB63.8	Phase 2	[10]
ONO-9054	DM5O6GC	Glaucoma/ocular hypertension	9C61	Phase 2	[27]
PGF2alpha	DM4XAU7	Solid tumour/cancer	2A00-2F9Z	Clinical trial	[10]
BUTAPROST	DMVYNJZ	Discovery agent	N.A.	Patented	[6]
DG041	DMVO9WM	Peripheral vascular disease	BD4Z	Discontinued in Phase 2	[38]
GR-63799X	DM13GK8	Asthma	CA23	Discontinued in Phase 1	[39]
U46619	DM13FX4	Discovery agent	N.A.	Investigative	[2]
carbacyclin	DMMBQYE	Discovery agent	N.A.	Investigative	[10]
PGD2	DMYDW6J	Discovery agent	N.A.	Investigative	[5]
butaprost (free acid form)	DM5MZHP	Discovery agent	N.A.	Investigative	[2]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin D2 receptor (PTGDR)	TTNVEIR	PD2R_HUMAN	Agonist	[2]
Prostaglandin E2 receptor EP1 (PTGER1)	TTG1QMU	PE2R1_HUMAN	Agonist	[3]
Prostaglandin E2 receptor EP3 (PTGER3)	TTPNGDE	PE2R3_HUMAN	Agonist	[2]
Prostaglandin F2-alpha receptor (PTGFR)	TTT2ZAR	PF2R_HUMAN	Agonist	[2]
Thromboxane A2 receptor (TBXA2R)	TT2O84V	TA2R_HUMAN	Agonist	[2]

References

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