Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMH7FC9)

Drug Name

3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide Drug Info

Synonyms

3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide; CDPPB; 781652-57-1; mGluR5 Ligand, CDPPB; CHEMBL190270; GTPL1422; SCHEMBL1823352; CTK5E5464; DTXSID80459996; MolPort-009-199-287; ZINC3986698; BDBM50156071; IN1239; AKOS024457497; RTC-070344; NCGC00370800-01; KB-75992; EN002594; TC-070344; DB-075421; FT-0763465; B7324; A9858; 3-cyano-N-[2,5-di(phenyl)pyrazol-3-yl]benzamide; 3-Cyano-N-1,3-diphenyl-1H-pyrazol-5-yl)benzamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 11245456
CAS Number: CAS 781652-57-1
TTD Drug ID: DMH7FC9

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Metabotropic glutamate receptor 5 (mGluR5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AFQ056	DMMHSLC	Fragile X syndrome	LD55	Phase 2/3	[3]
ADX-48621	DM6GTMD	Parkinson disease	8A00.0	Phase 2/3	[4]
RG-7090	DMX8JYN	Fragile X syndrome	LD55	Phase 2	[5]
STX-107	DMLNKX7	Autism spectrum disorder	6A02	Phase 2	[6]
ADX10059	DMGVKHQ	Anxiety disorder	6B00-6B0Z	Phase 2	[7]
McN3377	DMTCADJ	Fragile X syndrome	LD55	Phase 1/2	[8]
MK-3328	DMW2O5D	Alzheimer disease	8A20	Phase 1	[9]
[3H]fenobam	DMBOXA1	Allodynia	MB40.1	Phase 1	[10]
RG7342	DMIW5NG	Schizophrenia	6A20	Phase 1	[11]
BMS-984923	DMFNDUL	Alzheimer disease	8A20	Phase 1	[12]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Metabotropic glutamate receptor 5 (mGluR5)	TTHS256	GRM5_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1422).
2	Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo. JMed Chem. 2004 Nov 18;47(24):5825-8.
3	Metabolism and disposition of the metabotropic glutamate receptor 5 antagonist (mGluR5) mavoglurant (AFQ056) in healthy subjects. Drug Metab Dispos. 2013 Sep;41(9):1626-41.
4	Pipeline of Addex Pharma. Addex Pharma. 2009.
5	The challenges of clinical trials in fragile X syndrome. Psychopharmacology (Berl) 2014; 231(6): 1237-1250.
6	Social Communication is an Emerging Target for Pharmacotherapy in Autism Spectrum Disorder - A Review of the Literature on Potential Agents. J Can Acad Child Adolesc Psychiatry. 2014 February; 23(1):20-30.
7	A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and... Gut. 2009 Sep;58(9):1192-9.
8	Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.
9	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 293).
10	Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agon... J Pharmacol Exp Ther. 2005 Nov;315(2):711-21.
11	Clinical pipeline report, company report or official report of Roche.
12	Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer's Mouse Phenotypes. Cell Rep. 2017 Jul 5;20(1):76-88.