Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHTXSL)

• Drug Name: Arbekacin Drug Info
• Synonyms: Habekacin (TN)

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Approved	[1]

• Cross-matching ID:
  PubChem CID: 68682
  ChEBI ID: CHEBI:37922
  CAS Number: CAS 51025-85-5
  TTD Drug ID: DMHTXSL
  INTEDE Drug ID: DR0130

Molecule-Related Drug Atlas

Drug(s) Targeting Ribosome A (hRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Omacetaxine mepesuccinate	DMPU2WX	Adult acute monocytic leukemia		Approved	[4]

Drug(s) Metabolized By RNA cytidine acetyltransferase (hALP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[5]
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[6]
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[7]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[8]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[9]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[10]
Mesalazine	DMOL5IU	Diverticulitis		Approved	[11]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[12]
Netilmicin	DMRD1QK	Bacterial infection	1A00-1C4Z	Approved	[13]
Clonazepam	DMTO13J	Absence epilepsy		Approved	[14]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ribosome A (hRA)	TTA4FIU	NOUNIPROTAC	Modulator	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
RNA cytidine acetyltransferase (hALP) Main DME	DEZV4AP	NAT10_HUMAN	Substrate	[3]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7345).
• [2] Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
• [3] The novel enzymatic 3''-N-acetylation of arbekacin by an aminoglycoside 3-N-acetyltransferase of Streptomyces origin and the resulting activity. J Antibiot (Tokyo). 1998 Aug;51(8):735-42.
• [4] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [5] Arylamine N-acetyltransferase in human red blood cells. Biochem Pharmacol. 1992 Sep 25;44(6):1099-104.
• [6] A population and family study of N-acetyltransferase using caffeine urinary metabolites. Clin Pharmacol Ther. 1993 Aug;54(2):134-41.
• [7] Effect of H2-receptor antagonists on rat liver cytosolic acetyl CoA:arylamine N-acetyltransferase activity. Drug Metab Dispos. 1992 Jan-Feb;20(1):74-8.
• [8] Crystallization and preliminary X-ray characterization of arylamine N-acetyltransferase C (BanatC) from Bacillus anthracis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Oct 1;63(Pt 10):862-4.
• [9] Identification of cytochrome P450 and arylamine N-acetyltransferase isoforms involved in sulfadiazine metabolism. Drug Metab Dispos. 2005 Jul;33(7):969-76.
• [10] Genetic analysis of bacterial acetyltransferases: identification of amino acids determining the specificities of the aminoglycoside 6'-N-acetyltransferase Ib and IIa proteins. J Bacteriol. 1992 May;174(10):3196-203.
• [11] NAT1 genotypes do not predict response to mesalamine in patients with ulcerative colitis. Z Gastroenterol. 2008 Mar;46(3):259-65.
• [12] Xanthine oxidase inhibition by allopurinol affects the reliability of urinary caffeine metabolic ratios as markers for N-acetyltransferase 2 and CYP1A2 activities. Eur J Clin Pharmacol. 1999 Jan;54(11):869-76.
• [13] Aminoglycoside resistance resulting from tight drug binding to an altered aminoglycoside acetyltransferase. Antimicrob Agents Chemother. 2003 May;47(5):1577-83.
• [14] Effect of common NAT2 variant alleles in the acetylation of the major clonazepam metabolite, 7-aminoclonazepam. Drug Metab Lett. 2007 Jan;1(1):3-5.