DDI Drug Name |
DDI Drug ID |
Severity |
Mechanism |
Comorbidity |
REF |
Midostaurin |
DMI6E0R
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Midostaurin. |
Acute myeloid leukaemia [2A60]
|
[9] |
Inotersen |
DMJ93CT
|
Major |
Increased risk of bleeding by the combination of Omacetaxine mepesuccinate and Inotersen. |
Amyloidosis [5D00]
|
[8] |
Siltuximab |
DMGEATB
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Siltuximab. |
Anemia [3A00-3A9Z]
|
[9] |
Dupilumab |
DMOAD2Y
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Dupilumab. |
Atopic eczema [EA80]
|
[9] |
Eribulin |
DM1DX4Q
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Eribulin. |
Breast cancer [2C60-2C6Y]
|
[9] |
Talazoparib |
DM1KS78
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Talazoparib. |
Breast cancer [2C60-2C6Y]
|
[9] |
LY2835219 |
DM93VBZ
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and LY2835219. |
Breast cancer [2C60-2C6Y]
|
[9] |
Pralatrexate |
DMAO80I
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Pralatrexate. |
Breast cancer [2C60-2C6Y]
|
[9] |
Palbociclib |
DMD7L94
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Palbociclib. |
Breast cancer [2C60-2C6Y]
|
[9] |
Cabazitaxel |
DMPAZHC
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Cabazitaxel. |
Breast cancer [2C60-2C6Y]
|
[9] |
Bosutinib |
DMTI8YE
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Bosutinib. |
Breast cancer [2C60-2C6Y]
|
[9] |
Regorafenib |
DMHSY1I
|
Major |
Increased risk of bleeding by the combination of Omacetaxine mepesuccinate and Regorafenib. |
Colorectal cancer [2B91]
|
[8] |
Aflibercept |
DMT3D5I
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Aflibercept. |
Colorectal cancer [2B91]
|
[9] |
Ardeparin |
DMYRX8B
|
Major |
Increased risk of bleeding by the combination of Omacetaxine mepesuccinate and Ardeparin. |
Coronary thrombosis [BA43]
|
[8] |
Danaparoid |
DM6CLBN
|
Major |
Increased risk of bleeding by the combination of Omacetaxine mepesuccinate and Danaparoid. |
Deep vein thrombosis [BD71]
|
[8] |
Rivaroxaban |
DMQMBZ1
|
Major |
Increased risk of bleeding by the combination of Omacetaxine mepesuccinate and Rivaroxaban. |
Deep vein thrombosis [BD71]
|
[8] |
Polatuzumab vedotin |
DMF6Y0L
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Polatuzumab vedotin. |
Diffuse large B-cell lymphoma [2A81]
|
[9] |
Lisocabtagene maraleucel |
DMP45ME
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Lisocabtagene maraleucel. |
Diffuse large B-cell lymphoma [2A81]
|
[9] |
Axicabtagene ciloleucel |
DMYHN59
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Axicabtagene ciloleucel. |
Diffuse large B-cell lymphoma [2A81]
|
[9] |
Bay 80-6946 |
DMLOS5R
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Bay 80-6946. |
Follicular lymphoma [2A80]
|
[9] |
Tazemetostat |
DMWP1BH
|
Major |
Increased risk of bleeding by the combination of Omacetaxine mepesuccinate and Tazemetostat. |
Follicular lymphoma [2A80]
|
[8] |
Avapritinib |
DMK2GZX
|
Major |
Increased risk of bleeding by the combination of Omacetaxine mepesuccinate and Avapritinib. |
Gastrointestinal stromal tumour [2B5B]
|
[8] |
177Lu-DOTATATE |
DMT8GVU
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and 177Lu-DOTATATE. |
Hepatitis virus infection [1E50-1E51]
|
[9] |
Brentuximab vedotin |
DMWLC57
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Brentuximab vedotin. |
Hodgkin lymphoma [2B30]
|
[9] |
Teriflunomide |
DMQ2FKJ
|
Major |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Teriflunomide. |
Hyper-lipoproteinaemia [5C80]
|
[10] |
Olaratumab |
DMNYOIX
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Olaratumab. |
Kaposi sarcoma [2B57]
|
[9] |
Denosumab |
DMNI0KO
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Denosumab. |
Low bone mass disorder [FB83]
|
[11] |
Brigatinib |
DM7W94S
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Brigatinib. |
Lung cancer [2C25]
|
[9] |
Lurbinectedin |
DMEFRTZ
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Lurbinectedin. |
Lung cancer [2C25]
|
[9] |
Osimertinib |
DMRJLAT
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Osimertinib. |
Lung cancer [2C25]
|
[9] |
Belimumab |
DM3OBQF
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Belimumab. |
Lupus erythematosus [4A40]
|
[9] |
Inotuzumab ozogamicin |
DMAC130
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Inotuzumab ozogamicin. |
Malignant haematopoietic neoplasm [2B33]
|
[9] |
Ofatumumab |
DM295PR
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Ofatumumab. |
Mature B-cell leukaemia [2A82]
|
[9] |
Obinutuzumab |
DM3BVAE
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Obinutuzumab. |
Mature B-cell leukaemia [2A82]
|
[9] |
GDC-0199 |
DMH0QKA
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and GDC-0199. |
Mature B-cell leukaemia [2A82]
|
[9] |
IPI-145 |
DMWA24P
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and IPI-145. |
Mature B-cell leukaemia [2A82]
|
[9] |
Acalabrutinib |
DM7GCVW
|
Major |
Increased risk of bleeding by the combination of Omacetaxine mepesuccinate and Acalabrutinib. |
Mature B-cell lymphoma [2A85]
|
[8] |
Blinatumomab |
DMGECIJ
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Blinatumomab. |
Mature B-cell lymphoma [2A85]
|
[9] |
Ibrutinib |
DMHZCPO
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Ibrutinib. |
Mature B-cell lymphoma [2A85]
|
[9] |
Ponatinib |
DMYGJQO
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Ponatinib. |
Mature B-cell lymphoma [2A85]
|
[9] |
Arry-162 |
DM1P6FR
|
Major |
Increased risk of bleeding by the combination of Omacetaxine mepesuccinate and Arry-162. |
Melanoma [2C30]
|
[8] |
Ipilimumab |
DMJTIYK
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Ipilimumab. |
Melanoma [2C30]
|
[9] |
LGX818 |
DMNQXV8
|
Major |
Increased risk of bleeding by the combination of Omacetaxine mepesuccinate and LGX818. |
Melanoma [2C30]
|
[8] |
Carfilzomib |
DM48K0X
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Carfilzomib. |
Multiple myeloma [2A83]
|
[9] |
Selinexor |
DMBD4K3
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Selinexor. |
Multiple myeloma [2A83]
|
[9] |
Belantamab mafodotin |
DMBT3AI
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Belantamab mafodotin. |
Multiple myeloma [2A83]
|
[9] |
Elotuzumab |
DMEYHG9
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Elotuzumab. |
Multiple myeloma [2A83]
|
[9] |
Daratumumab |
DMKCIUZ
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Daratumumab. |
Multiple myeloma [2A83]
|
[9] |
Tecfidera |
DM2OVDT
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Tecfidera. |
Multiple sclerosis [8A40]
|
[9] |
Siponimod |
DM2R86O
|
Major |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Siponimod. |
Multiple sclerosis [8A40]
|
[12] |
Fingolimod |
DM5JVAN
|
Major |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Fingolimod. |
Multiple sclerosis [8A40]
|
[13] |
Ocrelizumab |
DMEZ2KH
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Ocrelizumab. |
Multiple sclerosis [8A40]
|
[9] |
Ozanimod |
DMT6AM2
|
Major |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Ozanimod. |
Multiple sclerosis [8A40]
|
[14] |
Deflazacort |
DMV0RNS
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Deflazacort. |
Muscular dystrophy [8C70]
|
[9] |
Romidepsin |
DMT5GNL
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Romidepsin. |
Mycosis fungoides [2B01]
|
[9] |
Prasugrel |
DM7MT6E
|
Major |
Increased risk of bleeding by the combination of Omacetaxine mepesuccinate and Prasugrel. |
Myocardial infarction [BA41-BA43]
|
[8] |
Inebilizumab |
DMI0RHA
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Inebilizumab. |
Nervous system paraneoplastic/autoimmune disorder [8E4A]
|
[9] |
Atezolizumab |
DMMF8U0
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Atezolizumab. |
Non-small cell lung cancer [2C25]
|
[9] |
Olaparib |
DM8QB1D
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Olaparib. |
Ovarian cancer [2C73]
|
[9] |
Rucaparib |
DM9PVX8
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Rucaparib. |
Ovarian cancer [2C73]
|
[9] |
MK-4827 |
DMLYGH4
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and MK-4827. |
Ovarian cancer [2C73]
|
[9] |
Brodalumab |
DMASDQ6
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Brodalumab. |
Psoriasis [EA90]
|
[9] |
Ustekinumab |
DMHTYK3
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Ustekinumab. |
Psoriasis [EA90]
|
[9] |
Tildrakizumab |
DMLW9HG
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Tildrakizumab. |
Psoriasis [EA90]
|
[9] |
Risankizumab |
DMM32GT
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Risankizumab. |
Psoriasis [EA90]
|
[9] |
Ixekizumab |
DMXW92T
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Ixekizumab. |
Psoriasis [EA90]
|
[9] |
Temsirolimus |
DMS104F
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Temsirolimus. |
Renal cell carcinoma [2C90]
|
[9] |
Tocilizumab |
DM7J6OR
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Tocilizumab. |
Rheumatoid arthritis [FA20]
|
[9] |
Canakinumab |
DM8HLO5
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Canakinumab. |
Rheumatoid arthritis [FA20]
|
[15] |
Rilonacept |
DMGLUQS
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Rilonacept. |
Rheumatoid arthritis [FA20]
|
[15] |
Golimumab |
DMHZV7X
|
Major |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Golimumab. |
Rheumatoid arthritis [FA20]
|
[16] |
Sarilumab |
DMOGNXY
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Sarilumab. |
Rheumatoid arthritis [FA20]
|
[9] |
Anthrax vaccine |
DM9GSWY
|
Moderate |
Antagonize the effect of Omacetaxine mepesuccinate when combined with Anthrax vaccine. |
Sepsis [1G40-1G41]
|
[17] |
Mogamulizumab |
DMISH0Z
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Mogamulizumab. |
Sezary syndrome [2B02]
|
[9] |
PDX-101 |
DM6OC53
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and PDX-101. |
Solid tumour/cancer [2A00-2F9Z]
|
[9] |
Trabectedin |
DMG3Y89
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Trabectedin. |
Solid tumour/cancer [2A00-2F9Z]
|
[9] |
LEE011 |
DMMX75K
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and LEE011. |
Solid tumour/cancer [2A00-2F9Z]
|
[9] |
Triptorelin |
DMTK4LS
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Triptorelin. |
Solid tumour/cancer [2A00-2F9Z]
|
[9] |
Pomalidomide |
DMTGBAX
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Pomalidomide. |
Systemic sclerosis [4A42]
|
[9] |
Plicamycin |
DM7C8YV
|
Major |
Increased risk of bleeding by the combination of Omacetaxine mepesuccinate and Plicamycin. |
Testicular cancer [2C80]
|
[8] |
Caplacizumab |
DMPUKA7
|
Major |
Increased risk of bleeding by the combination of Omacetaxine mepesuccinate and Caplacizumab. |
Thrombocytopenia [3B64]
|
[8] |
Apixaban |
DM89JLN
|
Major |
Increased risk of bleeding by the combination of Omacetaxine mepesuccinate and Apixaban. |
Thrombosis [DB61-GB90]
|
[8] |
Cangrelor |
DM8JRH0
|
Major |
Increased risk of bleeding by the combination of Omacetaxine mepesuccinate and Cangrelor. |
Thrombosis [DB61-GB90]
|
[8] |
Brilinta |
DMBR01X
|
Major |
Increased risk of bleeding by the combination of Omacetaxine mepesuccinate and Brilinta. |
Thrombosis [DB61-GB90]
|
[8] |
Cabozantinib |
DMIYDT4
|
Major |
Increased risk of bleeding by the combination of Omacetaxine mepesuccinate and Cabozantinib. |
Thyroid cancer [2D10]
|
[18] |
Belatacept |
DMXLYQF
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Belatacept. |
Transplant rejection [NE84]
|
[9] |
Durvalumab |
DM4PVDY
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Durvalumab. |
Ureteral cancer [2C92]
|
[9] |
Fluticasone |
DMGCSVF
|
Moderate |
Additive immunosuppressive effects by the combination of Omacetaxine mepesuccinate and Fluticasone. |
Vasomotor/allergic rhinitis [CA08]
|
[9] |
Betrixaban |
DM2C4RF
|
Major |
Increased risk of bleeding by the combination of Omacetaxine mepesuccinate and Betrixaban. |
Venous thromboembolism [BD72]
|
[8] |
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