General Information of Drug (ID: DMIMK84)

Drug Name
D2C7 Drug Info
Indication
Disease Entry ICD 11 Status REF
Glioblastoma of brain 2A00.00 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMIMK84

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [3]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [4]
Gefitinib DM15F0X Colon adenocarcinoma Approved [5]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [6]
Vandetanib DMRICNP Solid tumour/cancer 2A00-2F9Z Approved [7]
Dacomitinib DMOH8VY Non-small-cell lung cancer 2C25.Y Approved [8]
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [9]
SKI-758 DMQ8E9R Ischemia 8B10-8B11 Approved [10]
Epidermal growth factor DMVONE6 Vulnerary ND56.Z Approved [8]
Merimepodib DM0HS92 Breast cancer 2C60-2C65 Approved [11]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Anti-EGFRvIII CAR transduced PBL DMDKTYU Brain cancer 2A00 Phase 1/2 [12]
EGFRvIII CAR DMC284G Glioblastoma multiforme 2A00.0 Phase 1/2 [13]
Anti-EGFR V III CAR-T cells DM8EAGV Glioma 2A00.0 Phase 1/2 [14]
AMG 596 DM4G1SP Glioblastoma multiforme 2A00.0 Phase 1 [15]
EGFRvIII CAR T cells DM6XWV4 Glioblastoma multiforme 2A00.0 Phase 1 [16]
CAR-T cells targeting EGFRviii DMRSG04 Glioblastoma multiforme 2A00.0 Phase 1 [17]
Anti-EGFRvIII CAR T cells DM73920 Glioblastoma multiforme 2A00.0 Phase 1 [18]
CART-EGFRvIII T cells DMGPR1C Recurrent glioblastoma 2A00.00 Phase 1 [19]
EGFRvIII-CARs DMA46RN Recurrent glioblastoma 2A00.00 Phase 1 [20]
CAR-T cells targeting EGFRviii DMRSG04 Glioblastoma multiforme 2A00.0 Phase 1 [21]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Not Available [2]
Epidermal growth factor receptor variant III (EGFR vIII) TTZ6B2I EGFR_HUMAN Not Available [2]

References

1 ClinicalTrials.gov (NCT02303678) D2C7 for Adult Patients With Recurrent Malignant Glioma. U.S. National Institutes of Health.
2 Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations. J Immunother Cancer. 2019 May 29;7(1):142.
3 Nasopharyngeal carcinoma: Current treatment options and future directions. J Nasopharyng Carcinoma, 2014, 1(16): e16.
4 Triple negative breast cancer--current status and prospective targeted treatment based on HER1 (EGFR), TOP2A and C-MYC gene assessment. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2009 Mar;153(1):13-7.
5 Gefitinib ('Iressa', ZD1839) and new epidermal growth factor receptor inhibitors. Br J Cancer. 2004 Feb 9;90(3):566-72.
6 Quantitative prediction of fold resistance for inhibitors of EGFR. Biochemistry. 2009 Sep 8;48(35):8435-48.
7 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
8 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1797).
9 Boehringer Ingelheim. Product Development Pipeline. June 2 2009.
10 Synthesis and Src kinase inhibitory activity of a series of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-furyl-3-quinolinecarbonitriles. J Med Chem. 2006 Dec 28;49(26):7868-76.
11 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
12 ClinicalTrials.gov (NCT01454596) CAR T Cell Receptor Immunotherapy Targeting EGFRvIII for Patients With Malignant Gliomas Expressing EGFRvIII. U.S. National Institutes of Health.
13 EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss. Clin Cancer Res. 2014 Feb 15;20(4):972-84.
14 ClinicalTrials.gov (NCT03638206) Autologous CAR-T/TCR-T Cell Immunotherapy for Malignancies
15 Clinical pipeline report, company report or official report of Amgen.
16 ClinicalTrials.gov (NCT02664363) EGFRvIII CAR T Cells for Newly-Diagnosed WHO Grade IV Malignant Glioma
17 ClinicalTrials.gov (NCT03170141) Immunogene-modified T (IgT) Cells Against Glioblastoma Multiforme
18 ClinicalTrials.gov (NCT02844062) Pilot Study of Autologous Anti-EGFRvIII CAR T Cells in Recurrent Glioblastoma Multiforme
19 ClinicalTrials.gov (NCT02209376) Autologous T Cells Redirected to EGFRVIII-With a Chimeric Antigen Receptor in Patients With EGFRVIII+ Glioblastoma
20 ClinicalTrials.gov (NCT03283631) Intracerebral EGFR-vIII CAR-T Cells for Recurrent GBM
21 ClinicalTrials.gov (NCT03267173) Evaluate the Safety and Efficacy of CAR-T in the Treatment of Pancreatic Cancer.