Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMK6IIN)

• Drug Name: CORT113176 Drug Info
• Synonyms: Dazucorilant; Dazucorilant [INN]; UNII-HR4RD5RBJ6; HR4RD5RBJ6; CORT-113176; 1496508-34-9; CHEMBL3734774; CORT113176; Methanone, ((4aR)-1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-6-((4-(trifluoromethyl)phenyl)sulfonyl)-4ah-pyrazolo(3,4-g)isoquinolin-4a-yl)-2-pyridinyl-; Methanone, [(4aR)-1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-6-[[4-(trifluoromethyl)phenyl]sulfonyl]-4aH-pyrazolo[3,4-g]isoquinolin-4a-yl]-2-pyridinyl-; DAZUCORILANT [USAN]; SCHEMBL15455041; BDBM50265674; AKOS040756862; MS-30438; HY-132811; CS-0204060; (R)-(1-(4-fluorophenyl)-6-((4-(trifluoromethyl)phenyl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(pyridin-2-yl)methanone; {(4aR)-1-(4-fluorophenyl)-6-[4-(trifluoromethyl)benzene-1-sulfonyl]-1,4,5,6,7,8-hexahydro-4aH-pyrazolo[3,4-g]isoquinolin-4a- yl}(pyridin-2-yl)methanone

Indication

Disease Entry	ICD 11	Status	REF
Amyotrophic lateral sclerosis	8B60.0	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 72192163
  TTD Drug ID: DMK6IIN

Molecule-Related Drug Atlas

Drug(s) Targeting Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[3]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[4]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[5]
Fluticasone	DMGCSVF	Allergic rhinitis	CA08.0	Approved	[6]
Betamethasone Valerate	DMMIAXO	Dermatological disease	DA24.Y	Approved	[4]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[4]
Deflazacort	DMV0RNS	Duchenne dystrophy	8C70	Approved	[4]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[7]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[8]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[9]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucocorticoid receptor (NR3C1)	TTYRL6O	GCR_HUMAN	Modulator	[2]

References

• [1] ClinicalTrials.gov (NCT05407324) A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Evaluating Safety and Efficacy of CORT113176 (Dazucorilant) in Patients With Amyotrophic Lateral Sclerosis (DAZALS). U.S.National Institutes of Health.
• [2] Long-term effects of the glucocorticoid receptor modulator CORT113176 in murine motoneuron degeneration. Brain Res. 2020 Jan 15;1727:146551.
• [3] Interaction between the glucocorticoid and erythropoietin receptors in human erythroid cells. Exp Hematol. 2009 May;37(5):559-72.
• [4] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [5] Aldosterone (mineralocorticoid) equivalent to prednisolone (glucocorticoid) in reversing hearing loss in MRL/MpJ-Fas1pr autoimmune mice. Laryngoscope. 2000 Nov;110(11):1902-6.
• [6] Fluticasone furoate nasal spray in allergic rhinitis. Drugs Today (Barc). 2008 Apr;44(4):251-60.
• [7] Cytochromes P450 (CYP) in the Poeciliopsis lucida hepatocellular carcinoma cell line (PLHC-1): dose- and time-dependent glucocorticoid potentiation of CYP1A induction without induction of CYP3A. ArchBiochem Biophys. 1996 May 1;329(1):113-22.
• [8] PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide. Eur J Pharm Sci. 2009 Mar 2;36(4-5):565-71.
• [9] The glucocorticoid agonist activities of mifepristone (RU486) and progesterone are dependent on glucocorticoid receptor levels but not on EC50 values. Steroids. 2007 Jun;72(6-7):600-8.