Details of the Drug

General Information of Drug (ID: DM4BDON)

Drug Name

Methylprednisolone

Synonyms

Depo-medrol; M-predrol; Medrol; Medrol Acetate

Indication

Disease Entry	ICD 11	Status	REF
Acute adrenal insufficiency	N.A.	Approved	[1]
Acute asthma	CA23	Approved	[1]
Addison disease	5A74.0	Approved	[1]
Allergic rhinitis	CA08.0	Approved	[1]
Angioedema	4A00.15	Approved	[1]
Aspiration pneumonitis	N.A.	Approved	[1]
Autoimmune haemolytic anaemia	3A20	Approved	[1]
Bursitis	N.A.	Approved	[1]
Cerebral edema	8D60.1	Approved	[1]
Chronic graft versus host disease	N.A.	Approved	[1]
Congenital adrenal hyperplasia	5A71.01	Approved	[1]
Crohn disease	DD70	Approved	[1]
Dermatitis herpetiformis	EB44	Approved	[1]
Diamond-Blackfan anemia	N.A.	Approved	[1]
Disorder of orbital region	N.A.	Approved	[1]
Epicondylitis	N.A.	Approved	[1]
Erythema multiforme	N.A.	Approved	[1]
Exanthem	N.A.	Approved	[1]
Fever	MG26	Approved	[1]
Granuloma annulare	N.A.	Approved	[1]
Inflammatory bowel disease	DD72	Approved	[1]
Ischemia-reperfusion injury	DB98.B	Approved	[1]
Leukemia	N.A.	Approved	[1]
Lupus nephritis	4A40.0Y	Approved	[1]
Microscopic polyangiitis	N.A.	Approved	[1]
Miliary tuberculosis	N.A.	Approved	[1]
Multiple sclerosis	8A40	Approved	[1]
Mycosis fungoides	2B01	Approved	[1]
Myeloproliferative neoplasm	2A20	Approved	[1]
Pneumocystis pneumonia	CA40.20	Approved	[1]
Primary cutaneous T-cell lymphoma	N.A.	Approved	[1]
Psoriasis	EA90	Approved	[1]
Psoriatic arthritis	FA21	Approved	[1]
Rheumatic heart disease	N.A.	Approved	[1]
Rheumatoid arthritis	FA20	Approved	[2]
Sarcoidosis	4B20.5	Approved	[1]
Seasonal allergic rhinitis	CA08.01	Approved	[1]
Serum sickness	N.A.	Approved	[1]
Severe asthma	CA23	Approved	[1]
Skin disease	EA00-EM0Z	Approved	[1]
Solid tumour/cancer	2A00-2F9Z	Approved	[2]
Systemic lupus erythematosus	4A40.0	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 3	[3]
Acquired thrombocytopenia	N.A.	Investigative	[1]
Asthma	CA23	Investigative	[1]
Beta-thalassemia major	N.A.	Investigative	[1]
Classic Hodgkin lymphoma	N.A.	Investigative	[1]
Follicular lymphoma	2A80	Investigative	[1]
Perennial allergic rhinitis	CA08.03	Investigative	[1]
Spinal cord injury	ND51.2	Investigative	[4]
Synovitis	N.A.	Investigative	[1]
Trichinellosis	N.A.	Investigative	[1]
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Therapeutic Class

Anticancer Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

374.5

Logarithm of the Partition Coefficient (xlogp)

1.9

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

ADMET Property

BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [5]
Bioavailability: 82% of drug becomes completely available to its intended biological destination(s) [6]
Clearance: The drug present in the plasma can be removed from the body at the rate of 6.1 mL/min/kg [7]
Elimination: 4.9% of drug is excreted from urine in the unchanged form [5]
Half-life: The concentration or amount of drug in body reduced by one-half in 2.3 hours [7]
MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 11.1354 micromolar/kg/day [8]
Unbound Fraction: The unbound fraction of drug in plasma is 0.23% [7]
Vd: Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma 1.2 L/kg [7]
Water Solubility: The ability of drug to dissolve in water is measured as 0.3236 mg/mL [5]

Adverse Drug Reaction (ADR)

ADR Term	Variation	Related DOT	DOT ID	REF
Hepatotoxicity	Not Available	TAT	OT2CJ91O	[9]
Hepatotoxicity	Not Available	NR3C1	OTCI2YDI	[9]
Idiopathic thrombocytopenic purpura	Not Available	THPO	OTO73DZ2	[9]
Idiopathic thrombocytopenic purpura	Not Available	SELP	OTWR90PK	[9]
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Chemical Identifiers

Formula: C22H30O5
IUPAC Name: (6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
Canonical SMILES: C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)C=C4)C)O)C)(C(=O)CO)O
InChI: InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1
InChIKey: VHRSUDSXCMQTMA-PJHHCJLFSA-N

Cross-matching ID

PubChem CID: 6741
ChEBI ID: CHEBI:6888
CAS Number: 83-43-2
DrugBank ID: DB00959
TTD ID: D08PIQ
VARIDT ID: DR00128
INTEDE ID: DR1056
ACDINA ID: D00420

Combinatorial Drugs (CBD)

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Repurposed Drugs (RPD)

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Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucocorticoid receptor (NR3C1)	TTYRL6O	GCR_HUMAN	Modulator	[10]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[11]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)_{Main DME}	DE4LYSA	CP3A4_HUMAN	Substrate	[12]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)	OTO7FJA9	DHI1_HUMAN	Gene/Protein Processing	[13]
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Gene/Protein Processing	[13]
2'-5'-oligoadenylate synthase 3 (OAS3)	OT6E5FYS	OAS3_HUMAN	Gene/Protein Processing	[13]
2'-5'-oligoadenylate synthase-like protein (OASL)	OTZ05YRP	OASL_HUMAN	Gene/Protein Processing	[13]
5-hydroxytryptamine receptor 3A (HTR3A)	OTAIV1AK	5HT3A_HUMAN	Gene/Protein Processing	[14]
Adenosine receptor A2a (ADORA2A)	OTVRBZ0I	AA2AR_HUMAN	Gene/Protein Processing	[13]
Aldehyde oxidase (AOX1)	OT2FZP6H	AOXA_HUMAN	Gene/Protein Processing	[13]
Amphoterin-induced protein 2 (AMIGO2)	OTPAIT1O	AMGO2_HUMAN	Gene/Protein Processing	[13]
Anthrax toxin receptor 1 (ANTXR1)	OT5W1GPC	ANTR1_HUMAN	Gene/Protein Processing	[13]
Antiviral innate immune response receptor RIG-I (RIGI)	OTFIIC43	RIGI_HUMAN	Gene/Protein Processing	[13]

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Molecular Interaction Atlas (MIA)

MIA Detail

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Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Methylprednisolone

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
Larotrectinib	DM26CQR	Moderate	Decreased metabolism of Methylprednisolone caused by Larotrectinib mediated inhibition of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[15]
Armodafinil	DMGB035	Minor	Increased metabolism of Methylprednisolone caused by Armodafinil mediated induction of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[16]
LEE011	DMMX75K	Moderate	Decreased metabolism of Methylprednisolone caused by LEE011 mediated inhibition of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[17]
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Coadministration of a Drug Treating the Disease Different from Methylprednisolone (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Sodium bicarbonate	DMMU6BJ	Minor	Decreased absorption of Methylprednisolone due to altered gastric pH caused by Sodium bicarbonate.	Acidosis [5C73]	[18]
Posaconazole	DMUL5EW	Major	Decreased metabolism of Methylprednisolone caused by Posaconazole mediated inhibition of CYP450 enzyme.	Aspergillosis [1F20]	[19]
Levalbuterol	DM5YBO1	Minor	Increased risk of hypokalemia by the combination of Methylprednisolone and Levalbuterol.	Asthma [CA23]	[15]
Pirbuterol	DMI5678	Minor	Increased risk of hypokalemia by the combination of Methylprednisolone and Pirbuterol.	Asthma [CA23]	[19]
Salbutamol	DMN9CWF	Minor	Increased risk of hypokalemia by the combination of Methylprednisolone and Salbutamol.	Asthma [CA23]	[15]
Roflumilast	DMPGHY8	Moderate	Additive immunosuppressive effects by the combination of Methylprednisolone and Roflumilast.	Asthma [CA23]	[20]
Formoterol	DMSOURV	Minor	Increased risk of hypokalemia by the combination of Methylprednisolone and Formoterol.	Asthma [CA23]	[19]
Ofloxacin	DM0VQN3	Major	Increased risk of tendinitis/tendon rupture by the combination of Methylprednisolone and Ofloxacin.	Bacterial infection [1A00-1C4Z]	[21]
Dalfopristin	DM4LTKV	Moderate	Decreased metabolism of Methylprednisolone caused by Dalfopristin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[22]
Clarithromycin	DM4M1SG	Major	Decreased metabolism of Methylprednisolone caused by Clarithromycin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[19]
Sparfloxacin	DMB4HCT	Major	Increased risk of tendinitis/tendon rupture by the combination of Methylprednisolone and Sparfloxacin.	Bacterial infection [1A00-1C4Z]	[21]
Gemifloxacin	DMHT34O	Major	Increased risk of tendinitis/tendon rupture by the combination of Methylprednisolone and Gemifloxacin.	Bacterial infection [1A00-1C4Z]	[21]
Norfloxacin	DMIZ6W2	Major	Increased risk of tendinitis/tendon rupture by the combination of Methylprednisolone and Norfloxacin.	Bacterial infection [1A00-1C4Z]	[21]
ABT-492	DMJFD2I	Major	Increased risk of tendinitis/tendon rupture by the combination of Methylprednisolone and ABT-492.	Bacterial infection [1A00-1C4Z]	[21]
Levofloxacin	DMS60RB	Major	Increased risk of tendinitis/tendon rupture by the combination of Methylprednisolone and Levofloxacin.	Bacterial infection [1A00-1C4Z]	[21]
Troleandomycin	DMUZNIG	Major	Decreased metabolism of Methylprednisolone caused by Troleandomycin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[19]
Lomefloxacin	DMVRH9C	Major	Increased risk of tendinitis/tendon rupture by the combination of Methylprednisolone and Lomefloxacin.	Bacterial infection [1A00-1C4Z]	[21]
Telithromycin	DMZ4P3A	Major	Decreased metabolism of Methylprednisolone caused by Telithromycin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[19]
Lapatinib	DM3BH1Y	Moderate	Decreased metabolism of Methylprednisolone caused by Lapatinib mediated inhibition of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[23]
Tucatinib	DMBESUA	Major	Decreased metabolism of Methylprednisolone caused by Tucatinib mediated inhibition of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[19]
Vilanterol	DMF5EK1	Minor	Increased risk of hypokalemia by the combination of Methylprednisolone and Vilanterol.	Chronic obstructive pulmonary disease [CA22]	[15]
Indacaterol	DMQJHR7	Minor	Increased risk of hypokalemia by the combination of Methylprednisolone and Indacaterol.	Chronic obstructive pulmonary disease [CA22]	[19]
Arformoterol	DMYM974	Minor	Increased risk of hypokalemia by the combination of Methylprednisolone and Arformoterol.	Chronic obstructive pulmonary disease [CA22]	[19]
Ketoprofen	DMRKXPT	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Methylprednisolone and Ketoprofen.	Chronic pain [MG30]	[24]
Isoproterenol	DMK7MEY	Minor	Increased risk of hypokalemia by the combination of Methylprednisolone and Isoproterenol.	Conduction disorder [BC63]	[15]
Pancuronium	DMB0VY8	Moderate	Additive neuromuscular blocking effects by the combination of Methylprednisolone and Pancuronium.	Corneal disease [9A76-9A78]	[19]
Tubocurarine	DMBZIVP	Moderate	Additive neuromuscular blocking effects by the combination of Methylprednisolone and Tubocurarine.	Corneal disease [9A76-9A78]	[19]
Ivacaftor	DMZC1HS	Moderate	Decreased clearance of Methylprednisolone due to the transporter inhibition by Ivacaftor.	Cystic fibrosis [CA25]	[25]
MK-8228	DMOB58Q	Moderate	Decreased metabolism of Methylprednisolone caused by MK-8228 mediated inhibition of CYP450 enzyme.	Cytomegaloviral disease [1D82]	[26]
Nefazodone	DM4ZS8M	Major	Decreased metabolism of Methylprednisolone caused by Nefazodone mediated inhibition of CYP450 enzyme.	Depression [6A70-6A7Z]	[19]
Stiripentol	DMMSDOY	Moderate	Decreased metabolism of Methylprednisolone caused by Stiripentol mediated inhibition of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[27]
Fosphenytoin	DMOX3LB	Moderate	Increased metabolism of Methylprednisolone caused by Fosphenytoin mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[28]
Phenobarbital	DMXZOCG	Moderate	Increased metabolism of Methylprednisolone caused by Phenobarbital mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[29]
Tazemetostat	DMWP1BH	Moderate	Increased metabolism of Methylprednisolone caused by Tazemetostat mediated induction of CYP450 enzyme.	Follicular lymphoma [2A80]	[30]
Itraconazole	DMCR1MV	Major	Decreased metabolism of Methylprednisolone caused by Itraconazole mediated inhibition of CYP450 enzyme.	Fungal infection [1F29-1F2F]	[19]
Ketoconazole	DMPZI3Q	Major	Decreased metabolism of Methylprednisolone caused by Ketoconazole mediated inhibition of CYP450 enzyme.	Fungal infection [1F29-1F2F]	[19]
Boceprevir	DMBSHMF	Major	Decreased metabolism of Methylprednisolone caused by Boceprevir mediated inhibition of CYP450 enzyme.	Hepatitis virus infection [1E50-1E51]	[19]
Telaprevir	DMMRV29	Major	Decreased metabolism of Methylprednisolone caused by Telaprevir mediated inhibition of CYP450 enzyme.	Hepatitis virus infection [1E50-1E51]	[19]
Rifampin	DMA8J1G	Moderate	Increased metabolism of Methylprednisolone caused by Rifampin mediated induction of CYP450 enzyme.	HIV-infected patients with tuberculosis [1B10-1B14]	[31]
Rifapentine	DMCHV4I	Moderate	Increased metabolism of Methylprednisolone caused by Rifapentine mediated induction of CYP450 enzyme.	HIV-infected patients with tuberculosis [1B10-1B14]	[32]
Fosamprenavir	DM4W9B3	Major	Decreased metabolism of Methylprednisolone caused by Fosamprenavir mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[19]
Cobicistat	DM6L4H2	Major	Decreased metabolism of Methylprednisolone caused by Cobicistat mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[19]
Saquinavir	DMG814N	Major	Decreased metabolism of Methylprednisolone caused by Saquinavir mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[19]
Darunavir	DMN3GCH	Moderate	Decreased metabolism of Methylprednisolone caused by Darunavir mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[19]
Atazanavir	DMSYRBX	Major	Decreased metabolism of Methylprednisolone caused by Atazanavir mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[19]
Bempedoic acid	DM1CI9R	Major	Increased risk of tendinitis/tendon rupture by the combination of Methylprednisolone and Bempedoic acid.	Hyper-lipoproteinaemia [5C80]	[33]
Teriflunomide	DMQ2FKJ	Major	Additive immunosuppressive effects by the combination of Methylprednisolone and Teriflunomide.	Hyper-lipoproteinaemia [5C80]	[34]
Berotralstat	DMWA2DZ	Moderate	Decreased metabolism of Methylprednisolone caused by Berotralstat mediated inhibition of CYP450 enzyme.	Innate/adaptive immunodeficiency [4A00]	[35]
Amobarbital	DM0GQ8N	Moderate	Increased metabolism of Methylprednisolone caused by Amobarbital mediated induction of CYP450 enzyme.	Insomnia [7A00-7A0Z]	[29]
Denosumab	DMNI0KO	Moderate	Additive immunosuppressive effects by the combination of Methylprednisolone and Denosumab.	Low bone mass disorder [FB83]	[36]
PF-06463922	DMKM7EW	Moderate	Increased metabolism of Methylprednisolone caused by PF-06463922 mediated induction of CYP450 enzyme.	Lung cancer [2C25]	[37]
Selpercatinib	DMZR15V	Moderate	Decreased metabolism of Methylprednisolone caused by Selpercatinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[20]
Idelalisib	DM602WT	Major	Decreased metabolism of Methylprednisolone caused by Idelalisib mediated inhibition of CYP450 enzyme.	Mature B-cell leukaemia [2A82]	[19]
IPI-145	DMWA24P	Moderate	Decreased metabolism of Methylprednisolone caused by IPI-145 mediated inhibition of CYP450 enzyme.	Mature B-cell leukaemia [2A82]	[38]
Nivolumab	DMAB9QE	Moderate	Additive immunosuppressive effects by the combination of Methylprednisolone and Nivolumab.	Melanoma [2C30]	[19]
Pembrolizumab	DMFQEA6	Moderate	Additive immunosuppressive effects by the combination of Methylprednisolone and Pembrolizumab.	Melanoma [2C30]	[19]
Ipilimumab	DMJTIYK	Moderate	Additive immunosuppressive effects by the combination of Methylprednisolone and Ipilimumab.	Melanoma [2C30]	[19]
Cemiplimab	DMKMJHE	Moderate	Additive immunosuppressive effects by the combination of Methylprednisolone and Cemiplimab.	Melanoma [2C30]	[19]
Dabrafenib	DMX6OE3	Moderate	Increased metabolism of Methylprednisolone caused by Dabrafenib mediated induction of CYP450 enzyme.	Melanoma [2C30]	[20]
Thalidomide	DM70BU5	Major	Additive thrombogenic effects by the combination of Methylprednisolone and Thalidomide.	Multiple myeloma [2A83]	[39]
Tecfidera	DM2OVDT	Moderate	Additive immunosuppressive effects by the combination of Methylprednisolone and Tecfidera.	Multiple sclerosis [8A40]	[40]
Siponimod	DM2R86O	Major	Additive immunosuppressive effects by the combination of Methylprednisolone and Siponimod.	Multiple sclerosis [8A40]	[15]
Fingolimod	DM5JVAN	Major	Additive immunosuppressive effects by the combination of Methylprednisolone and Fingolimod.	Multiple sclerosis [8A40]	[41]
Ocrelizumab	DMEZ2KH	Moderate	Additive immunosuppressive effects by the combination of Methylprednisolone and Ocrelizumab.	Multiple sclerosis [8A40]	[42]
Ozanimod	DMT6AM2	Major	Additive immunosuppressive effects by the combination of Methylprednisolone and Ozanimod.	Multiple sclerosis [8A40]	[20]
Fedratinib	DM4ZBK6	Moderate	Decreased metabolism of Methylprednisolone caused by Fedratinib mediated inhibition of CYP450 enzyme.	Myeloproliferative neoplasm [2A20]	[19]
Omacetaxine mepesuccinate	DMPU2WX	Moderate	Additive immunosuppressive effects by the combination of Methylprednisolone and Omacetaxine mepesuccinate.	Myeloproliferative neoplasm [2A20]	[43]
Bupropion	DM5PCS7	Major	Increased risk of lowers seizure threshold by the combination of Methylprednisolone and Bupropion.	Nicotine use disorder [6C4A]	[44]
Atezolizumab	DMMF8U0	Moderate	Additive immunosuppressive effects by the combination of Methylprednisolone and Atezolizumab.	Non-small cell lung cancer [2C25]	[19]
Rucaparib	DM9PVX8	Moderate	Decreased metabolism of Methylprednisolone caused by Rucaparib mediated inhibition of CYP450 enzyme.	Ovarian cancer [2C73]	[45]
Ibuprofen	DM8VCBE	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Methylprednisolone and Ibuprofen.	Pain [MG30-MG3Z]	[24]
Abametapir	DM2RX0I	Moderate	Decreased metabolism of Methylprednisolone caused by Abametapir mediated inhibition of CYP450 enzyme.	Pediculosis [1G00]	[46]
Lefamulin	DME6G97	Moderate	Decreased metabolism of Methylprednisolone caused by Lefamulin mediated inhibition of CYP450 enzyme.	Pneumonia [CA40]	[47]
Choline salicylate	DM8P137	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Methylprednisolone and Choline salicylate.	Postoperative inflammation [1A00-CA43]	[48]
Bromfenac	DMKB79O	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Methylprednisolone and Bromfenac.	Postoperative inflammation [1A00-CA43]	[24]
Lonafarnib	DMGM2Z6	Major	Decreased metabolism of Methylprednisolone caused by Lonafarnib mediated inhibition of CYP450 enzyme.	Premature ageing appearance [LD2B]	[19]
Temsirolimus	DMS104F	Moderate	Increased plasma concentrations of Methylprednisolone and Temsirolimus due to competitive inhibition of the same metabolic pathway.	Renal cell carcinoma [2C90]	[49]
Gatifloxacin	DMSL679	Major	Increased risk of tendinitis/tendon rupture by the combination of Methylprednisolone and Gatifloxacin.	Respiratory infection [CA07-CA4Z]	[21]
Salsalate	DM13P4C	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Methylprednisolone and Salsalate.	Rheumatoid arthritis [FA20]	[48]
Canakinumab	DM8HLO5	Moderate	Additive immunosuppressive effects by the combination of Methylprednisolone and Canakinumab.	Rheumatoid arthritis [FA20]	[50]
Oxaprozin	DM9UB0P	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Methylprednisolone and Oxaprozin.	Rheumatoid arthritis [FA20]	[24]
Rilonacept	DMGLUQS	Moderate	Additive immunosuppressive effects by the combination of Methylprednisolone and Rilonacept.	Rheumatoid arthritis [FA20]	[50]
Golimumab	DMHZV7X	Major	Additive immunosuppressive effects by the combination of Methylprednisolone and Golimumab.	Rheumatoid arthritis [FA20]	[51]
Leflunomide	DMR8ONJ	Major	Additive immunosuppressive effects by the combination of Methylprednisolone and Leflunomide.	Rheumatoid arthritis [FA20]	[34]
Anthrax vaccine	DM9GSWY	Moderate	Antagonize the effect of Methylprednisolone when combined with Anthrax vaccine.	Sepsis [1G40-1G41]	[52]
Voxelotor	DMCS6M5	Moderate	Decreased metabolism of Methylprednisolone caused by Voxelotor mediated inhibition of CYP450 enzyme.	Sickle-cell disorder [3A51]	[19]
Telotristat ethyl	DMDIYFZ	Moderate	Increased metabolism of Methylprednisolone caused by Telotristat ethyl mediated induction of CYP450 enzyme.	Small intestine developmental anomaly [DA90]	[20]
Pitolisant	DM8RFNJ	Moderate	Increased risk of GI mucosal injury/bleeding risk by the combination of Methylprednisolone and Pitolisant.	Somnolence [MG42]	[20]
Fostamatinib	DM6AUHV	Moderate	Decreased metabolism of Methylprednisolone caused by Fostamatinib mediated inhibition of CYP450 enzyme.	Thrombocytopenia [3B64]	[53]
Doxacurium	DMKE7L9	Moderate	Additive neuromuscular blocking effects by the combination of Methylprednisolone and Doxacurium.	Tonus and reflex abnormality [MB47]	[19]
Vecuronium	DMP0UK2	Moderate	Additive neuromuscular blocking effects by the combination of Methylprednisolone and Vecuronium.	Tonus and reflex abnormality [MB47]	[19]
Durvalumab	DM4PVDY	Moderate	Additive immunosuppressive effects by the combination of Methylprednisolone and Durvalumab.	Ureteral cancer [2C92]	[19]
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⏷ Show the Full List of 92 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Sodium lauryl sulfate	E00464	3423265	Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Stearic acid	E00079	5281	Emulsifying agent; Solubilizing agent; Viscosity-controlling agent; lubricant
Sunset yellow FCF	E00255	17730	Colorant
Beta-D-lactose	E00099	6134	Diluent; Dry powder inhaler carrier; Lyophilization aid
Calcium stearate	E00244	15324	lubricant
Carmellose sodium	E00625	Not Available	Disintegrant
Lactose monohydrate	E00393	104938	Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate	E00208	11177	lubricant
Saccharose	E00091	5988	Binding agent; Coating agent; Cryoprotectant; Diluent; Flavoring agent; Suspending agent; Viscosity-controlling agent
Silicon dioxide	E00670	Not Available	Anticaking agent; Opacifying agent; Viscosity-controlling agent
Sorbic acid	E00441	643460	Antimicrobial preservative
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⏷ Show the Full List of 11 Pharmaceutical Excipients of This Drug

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Methylprednisolone 4 mg tablet	4 mg	Oral Tablet	Oral
Methylprednisolone 2 mg tablet	2 mg	Oral Tablet	Oral
Methylprednisolone 16 mg tablet	16 mg	Oral Tablet	Oral
Methylprednisolone 32 mg tablet	32 mg	Oral Tablet	Oral
Methylprednisolone 8 mg tablet	8 mg	Oral Tablet	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

References

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