Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMKUHN9)

Drug Name
6-(3-Ethyl-phenylamino)-1H-pyrimidine-2,4-dione Drug Info
Synonyms CHEMBL51750; 72255-48-2; 2,4(1H,3H)-Pyrimidinedione, 6-[(3-ethylphenyl)amino]-; 6-(3-Ethyl-phenylamino)-1H-pyrimidine-2,4-dione; CTK2H2677; DTXSID90658211; BDBM50028320
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44297884
CAS Number
CAS 72255-48-2
TTD Drug ID
DMKUHN9

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting DNA topoisomerase (TOP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Karenitecin DMCRGY4 Lung cancer 2C25.0 Phase 3 [2]
Icofungipen DMTXNZK Fungal infection 1F29-1F2F Phase 2 [3]
TOPOSTATIN DMNZQO9 Discovery agent N.A. Investigative [4]
N*4*-Benzyl-6-chloro-pyrimidine-2,4-diamine DMNGSQK Discovery agent N.A. Investigative [5]
5-Bromo-6-p-tolylamino-1H-pyrimidine-2,4-dione DMTPRIW Discovery agent N.A. Investigative [5]
6-Benzylamino-1H-pyrimidine-2,4-dione DM8FUZL Discovery agent N.A. Investigative [5]
6-(3-Bromo-phenylamino)-1H-pyrimidine-2,4-dione DMMFWYX Discovery agent N.A. Investigative [1]
6-(Indan-5-ylamino)-1H-pyrimidine-2,4-dione DMSH107 Discovery agent N.A. Investigative [1]
6-Benzylamino-5-bromo-1H-pyrimidine-2,4-dione DMGJYWF Discovery agent N.A. Investigative [5]
2-Amino-6-(indan-5-ylamino)-3H-pyrimidin-4-one DMECHD0 Discovery agent N.A. Investigative [5]
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Drug(s) Targeting Herpes simplex virus DNA polymerase UL30 (HSV UL30)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [6]
Aciclovir DMYLOVR Genital herpes 1A94 Approved [7]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [8]
Valaciclovir DMHKS94 Genital herpes 1A94 Approved [9]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [7]
Valganciclovir DMS2IUH Virus infection 1A24-1D9Z Approved [10]
Penciclovir DMOUMDV Herpes simplex labialis 1F00.01 Approved [11]
Famciclovir DMJHLSD Meniere disease AB31.0 Approved [12]
Valacyclovir Hydrochloride DM5I1CE Herpes simplex virus infection 1F00 Approved [7]
Foscavir DM9KJLZ Cytomegalovirus retinitis 9B72.00 Approved [10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA topoisomerase (TOP) TT2GPK3 NOUNIPROTAC Inhibitor [1]
Herpes simplex virus DNA polymerase UL30 (HSV UL30) TTIU7X1 DPOL_HHV11 Inhibitor [1]

References

1 Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils. J Med Chem. 1980 Jan;23(1):34-8.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Crystallization and preliminary X-ray analysis of anti-cancer agent 3-(9-acridinylamino)-5-(hydroxymethyl)aniline complexed with the DNA hexamer d(CGTACG)2. Biochim Biophys Acta. 2003 Jan 3;1625(1):27-9.
4 Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba. J Nat Prod. 2001 Feb;64(2):204-7.
5 Inhibitors of Bacillus subtilis DNA polymerase III. Influence of modifications in the pyrimidine ring of anilino- and (benzylamino)pyrimidines. J Med Chem. 1986 May;29(5):676-81.
6 Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage. Mol Cancer Ther. 2009 Apr;8(4):864-72.
7 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
8 Application of real time polymerase chain reaction to the diagnosis and treatment of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation. Zhonghua Xue Ye Xue Za Zhi. 2009 Feb;30(2):77-81.
9 Extensive oral shedding of human herpesvirus 8 in a renal allograft recipient. Oral Microbiol Immunol. 2009 Apr;24(2):109-15.
10 Drug targets in cytomegalovirus infection. Infect Disord Drug Targets. 2009 Apr;9(2):201-22.
11 Antimicrobial strategies: inhibition of viral polymerases by 3'-hydroxyl nucleosides. Drugs. 2009;69(2):151-66.
12 Penciclovir cream--improved topical treatment for herpes simplex infections. Skin Pharmacol Physiol. 2004 Sep-Oct;17(5):214-8.