Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DML3HEM)

• Drug Name: Dicarboxylate Drug Info
• Synonyms: 1,3-Propanedioic acid; 9KX7ZMG0MK; AI3-15375; BRN 1751370; CHEBI:30794; Carboxyacetic acid; DICARBOXYLIC ACID C3; Dicarboxylate; Dicarboxylic acid; Dicarboxymethane; EINECS 205-503-0; Kyselina malonova; Kyselina malonova [Czech]; METAHNEDICARBOXYLIC ACID; MFCD00002707; Malonic acid; Malonic acid, 99%; Methanedicarbonic acid; Methanedicarboxylic acid; NSC 8124; NSC8124; OFOBLEOULBTSOW-UHFFFAOYSA-N; PROPANEDIOLIC ACID; Thallium malonate; UNII-9KX7ZMG0MK; USAF EK-695; alpha,omega-Dicarboxylic acid; malonic acid; propanedioic acid
• Cross-matching ID:
  PubChem CID: 867
  ChEBI ID: CHEBI:30794
  CAS Number: CAS 141-82-2
  TTD Drug ID: DML3HEM
  VARIDT Drug ID: DR01245

Molecule-Related Drug Atlas

Drug(s) Transported By Sodium/dicarboxylate cotransporter 3 (SLC13A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
alpha-ketoglutaric acid	DM5LFYN	Discovery agent	N.A.	Investigative	[2]
Succinate	DMPY09A	N. A.	N. A.	Investigative	[2]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[4]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[5]
Fructose	DM43AN2	Vomiting	MD90	Approved	[6]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[7]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[9]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[10]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[3]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[11]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[3]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Sodium/dicarboxylate cotransporter 1 (SLC13A2)	DTUO05P	S13A2_HUMAN	Substrate	[1]
Sodium/dicarboxylate cotransporter 3 (SLC13A3)	DTKXTPW	S13A3_HUMAN	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)	OTHCDQ22	PRGC1_HUMAN	Gene/Protein Processing	[3]

References

• [1] Evidence for epistatic interaction between VDR and SLC13A2 genes in the pathogenesis of hypocitraturia in recurrent calcium oxalate stone formers. J Nephrol. 2017 Jun;30(3):411-418.
• [2] SLC13A3 variants cause acute reversible leukoencephalopathy and -ketoglutarate accumulation. Ann Neurol. 2019 Mar;85(3):385-395.
• [3] A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1 expression and mitochondrial biogenesis. PLoS One. 2012;7(10):e46753. doi: 10.1371/journal.pone.0046753. Epub 2012 Oct 3.
• [4] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [5] Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor co-activator-1 protein. Br J Pharmacol. 2010 Oct;161(4):771-81. doi: 10.1111/j.1476-5381.2010.00900.x.
• [6] Effects of four-week high-fructose diet on gene expression in skeletal muscle of healthy men. Diabetes Metab. 2008 Feb;34(1):82-5. doi: 10.1016/j.diabet.2007.08.004. Epub 2007 Dec 11.
• [7] Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells. Diabetologia. 2010 May;53(5):955-65. doi: 10.1007/s00125-010-1676-1. Epub 2010 Feb 18.
• [8] AMPK activator acadesine fails to alleviate isoniazid-caused mitochondrial instability in HepG2 cells. J Appl Toxicol. 2017 Oct;37(10):1219-1224. doi: 10.1002/jat.3483. Epub 2017 May 29.
• [9] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [10] Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis. Toxicol Appl Pharmacol. 2016 Jul 1;302:1-9. doi: 10.1016/j.taap.2016.04.007. Epub 2016 Apr 16.
• [11] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.