Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLQJ5P)

Drug Name

AMG 228 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Activation-inducible TNFR family receptor (TNFRSF18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
INCAGN01876	DMNUXKA	Solid tumour/cancer	2A00-2F9Z	Phase 2	[3]
INCAGN1876	DM8XN4A	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[4]
TRX-518	DMQS5DY	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[5]
MK-4166	DML5V76	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]
REGN6569	DM0ZMNI	Squamous head and neck cell carcinom	2D60.0	Phase 1	[7]
TRX518	DM9IDUH	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
ASP1951	DMX4PWV	Solid tumour/cancer	2A00-2F9Z	Phase 1	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Activation-inducible TNFR family receptor (TNFRSF18)	TTG6LA7	TNR18_HUMAN	Agonist	[2]

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References

1	ClinicalTrials.gov (NCT02437916) Safety Study of AMG 228 to Treat Solid Tumors. U.S. National Institutes of Health.
2	Dose escalation results from a first-in-human, phase 1 study of glucocorticoid-induced TNF receptor-related protein agonist AMG 228 in patients with advanced solid tumors. J Immunother Cancer. 2018 Sep 25;6(1):93.
3	Clinical pipeline report, company report or official report of Agenus.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Immuno-oncology moves beyond PD-1. Nat Biotechnol. 2015 Jul;33(7):673-5.
6	Immuno-oncology moves beyond PD-1. Nat Biotechnol. 2015 Jul;33(7):673-5.
7	Clinical pipeline report, company report or official report of Regeneron Pharmaceuticals.
8	Clinical pipeline report, company report or official report of Leap Therapeutics.
9	ClinicalTrials.gov (NCT03799003) A Study of ASP1951 in Subjects With Advanced Solid Tumors. U.S. National Institutes of Health.