Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMM65W1)

• Drug Name: CX-717 Drug Info
• Synonyms: CX-1763; CX-546; CX-614; CX-727; CX-729; CX-743; CX-815; S-40929; First generation AMPA receptor modulators, Cortex/University of California; First-generation AMPAKINE compounds, University of California/Cortex

Indication

Disease Entry	ICD 11	Status	REF
Spinal cord injury	ND51.2	Phase 2	[1]
Alzheimer disease	8A20	Preclinical	[2]

• Cross-matching ID:
  PubChem CID: 3323368
  CAS Number: CAS 211735-82-9
  TTD Drug ID: DMM65W1

Molecule-Related Drug Atlas

Drug(s) Targeting Glutamate receptor AMPA (GRIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[4]
E-2007	DMJDYNQ	Diabetic neuropathy	8C0Z	Approved	[5]
Zopiclone	DMPI6Z0	Insomnia	7A00-7A0Z	Approved	[6]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[7]
Enflurane	DM0YJSB	Anaesthesia	9A78.6	Approved	[8]
Isoflurane	DMY6T31	Anaesthesia	9A78.6	Approved	[9]
Bromazepam	DMY9TCW	Anxiety disorder	6B00-6B0Z	Approved	[10]
Artemisinin SP	DMFETDK	Malaria	1F40-1F45	Approved	[11]
Dihydroergotoxine	DM5D6WZ	Alzheimer disease	8A20	Approved	[12]
Barbiturate	DMJIA6T	Anaesthesia	9A78.6	Approved	[13]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor AMPA (GRIA)	TTAN6JD	NOUNIPROTAC	Modulator	[3]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7842).
• [3] Acute sleep deprivation: the effects of the AMPAKINE compound CX717 on human cognitive performance, alertness and recovery sleep. J Psychopharmacol. 2012 Aug;26(8):1047-57.
• [4] Reduced inhibition of cortical glutamate and GABA release by halothane in mice lacking the K+ channel, TREK-1. Br J Pharmacol. 2007 Nov;152(6):939-45.
• [5] Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
• [6] Eszopiclone: its use in the treatment of insomnia. Neuropsychiatr Dis Treat. 2007 Aug;3(4):441-453.
• [7] Effects of sevoflurane on carrageenan- and fentanyl-induced pain hypersensitivity in Sprague-Dawley rats. Can J Anaesth. 2009 Feb;56(2):126-35.
• [8] Enflurane directly depresses glutamate AMPA and NMDA currents in mouse spinal cord motor neurons independent of actions on GABAA or glycine receptors. Anesthesiology. 2000 Oct;93(4):1075-84.
• [9] Transmembrane residues define the action of isoflurane at the GABAA receptor alpha-3 subunit. Brain Res. 2005 Jan 25;1032(1-2):30-5.
• [10] Glutamatergic and GABAergic modulations of ultrasonic vocalizations during maternal separation distress in mouse pups. Psychopharmacology (Berl). 2009 May;204(1):61-71.
• [11] GABA(A) receptor ligands and their therapeutic potentials. Curr Top Med Chem. 2002 Aug;2(8):817-32.
• [12] Pharmacologic management of Alzheimer disease, Part II: Antioxidants, antihypertensives, and ergoloid derivatives. Ann Pharmacother. 1999 Feb;33(2):188-97.
• [13] Anaesthetic drugs: linking molecular actions to clinical effects. Curr Pharm Des. 2006;12(28):3665-79.